Detailed information of TA system TA119883

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parE_1-relB/RelE(toxin)
• Location: 2037993..2038468
• Replicon: chromosome
• Accession: NZ_CP036495
• Organism: Pseudomonas viridiflava strain Psy35

Toxin (Protein)

• Gene name: parE_1
• Uniprot ID: -
• Locus tag: EZZ81_RS09595
• Protein ID: WP_080665244.1
• Coordinates: 2038187..2038468 (+)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A5E7EZR3
• Locus tag: EZZ81_RS09590
• Protein ID: WP_029242986.1
• Coordinates: 2037993..2038187 (+)
• Length: 65 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EZZ81_RS09570 (EZZ81_09720)	2033015..2033494	+	480	WP_029242983.1	ATP-binding protein	-
EZZ81_RS09575 (EZZ81_09725)	2033569..2035740	-	2172	WP_029242984.1	TonB-dependent siderophore receptor	-
EZZ81_RS09580 (EZZ81_09730)	2036007..2037248	+	1242	WP_029242985.1	M20/M25/M40 family metallo-hydrolase	-
EZZ81_RS09585 (EZZ81_09735)	2037346..2037756	+	411	WP_025995307.1	S24 family peptidase	-
EZZ81_RS09590 (EZZ81_09740)	2037993..2038187	+	195	WP_029242986.1	hypothetical protein	Antitoxin
EZZ81_RS09595 (EZZ81_09745)	2038187..2038468	+	282	WP_080665244.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
EZZ81_RS09600	2038643..2038771	-	129	Protein_1886	site-specific integrase	-
EZZ81_RS09605 (EZZ81_09750)	2038877..2039887	+	1011	WP_029242987.1	tRNA dihydrouridine(20/20a) synthase DusA	-
EZZ81_RS09610 (EZZ81_09755)	2040033..2040464	+	432	WP_029242988.1	universal stress protein	-
EZZ81_RS09615 (EZZ81_09760)	2040473..2040937	-	465	WP_004881182.1	response regulator	-
EZZ81_RS09620 (EZZ81_09765)	2040934..2043261	-	2328	WP_029242989.1	ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-90)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10517.27 Da
• Isoelectric Point: 9.8796

>T119883 WP_080665244.1 NZ_CP036495:2038187-2038468 [Pseudomonas viridiflava]
MLPIVWLQAAVNDLSSIILYISNENPSAARRLKSRLQAAPLPLVEHPYLFPLGRVSGTRELVAHPNYIIVYRIASDRVEI
VNVLHSRQTYPLT

Nucleotide

• Length: 282 bp

>T119883 NZ_CP036495:2038187-2038468 [Pseudomonas viridiflava]
ATGTTGCCCATTGTCTGGCTGCAAGCTGCTGTAAATGACCTTTCTTCAATCATCCTCTACATCTCCAATGAAAACCCCTC
TGCCGCTCGTCGCCTAAAATCACGTCTTCAGGCTGCGCCTTTACCATTAGTTGAACATCCTTATCTTTTTCCTCTGGGGC
GGGTTTCCGGTACGCGCGAACTCGTCGCGCATCCCAATTACATCATCGTTTACCGCATTGCCTCAGATCGAGTGGAGATC
GTGAACGTCTTGCATTCAAGGCAGACCTATCCGTTGACATGA

Antitoxin

Protein

• Length: 65 a.a.
• Molecular weight: 7095.90 Da
• Isoelectric Point: 4.1947

>AT119883 WP_029242986.1 NZ_CP036495:2037993-2038187 [Pseudomonas viridiflava]
MSTTLSPIVSEFDTQEQADSYDLWFRAKVEASLAEPGRAVPHDEVMARMDAIIEAAEARQRLGS

Nucleotide

• Length: 195 bp

>AT119883 NZ_CP036495:2037993-2038187 [Pseudomonas viridiflava]
ATGAGCACTACACTTTCCCCCATCGTTTCCGAATTTGATACGCAAGAGCAAGCTGATAGCTACGATCTCTGGTTTCGCGC
CAAGGTGGAAGCTTCGTTGGCCGAACCTGGACGTGCAGTGCCTCACGATGAAGTCATGGCGCGCATGGACGCGATCATTG
AGGCTGCTGAGGCCAGGCAGAGATTGGGTAGCTGA

Structures

Antitoxin

• AlphaFold DB: A0A5E7EZR3