Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relE-higA/HigB-HigA |
| Location | 5863004..5863995 | Replicon | chromosome |
| Accession | NZ_CP036494 | ||
| Organism | Pseudomonas putida strain PP1 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | - |
| Locus tag | EZZ80_RS27100 | Protein ID | WP_020190010.1 |
| Coordinates | 5863519..5863995 (-) | Length | 159 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | Q88R60 |
| Locus tag | EZZ80_RS27095 | Protein ID | WP_004575922.1 |
| Coordinates | 5863004..5863477 (-) | Length | 158 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| EZZ80_RS27055 (EZZ80_27635) | 5858165..5858854 | + | 690 | WP_010951649.1 | ABC transporter permease | - |
| EZZ80_RS27060 (EZZ80_27640) | 5858983..5860188 | + | 1206 | WP_010951648.1 | methyltransferase | - |
| EZZ80_RS27065 (EZZ80_27645) | 5860543..5860818 | - | 276 | WP_049588069.1 | DUF3077 domain-containing protein | - |
| EZZ80_RS27070 (EZZ80_27650) | 5861339..5861587 | + | 249 | WP_010951646.1 | hypothetical protein | - |
| EZZ80_RS27080 (EZZ80_27660) | 5862049..5862372 | + | 324 | WP_010951645.1 | helix-turn-helix transcriptional regulator | - |
| EZZ80_RS27085 (EZZ80_27665) | 5862369..5862584 | - | 216 | WP_010951644.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| EZZ80_RS27090 (EZZ80_27670) | 5862812..5862999 | + | 188 | Protein_5325 | integrase | - |
| EZZ80_RS27095 (EZZ80_27675) | 5863004..5863477 | - | 474 | WP_004575922.1 | transcriptional regulator | Antitoxin |
| EZZ80_RS27100 (EZZ80_27680) | 5863519..5863995 | - | 477 | WP_020190010.1 | type II toxin-antitoxin system HigB family toxin | Toxin |
| EZZ80_RS27105 (EZZ80_27685) | 5864054..5864260 | + | 207 | WP_014860378.1 | DUF3079 domain-containing protein | - |
| EZZ80_RS27110 (EZZ80_27690) | 5864326..5866623 | - | 2298 | WP_010951641.1 | TonB-dependent siderophore receptor | - |
| EZZ80_RS27115 (EZZ80_27695) | 5866764..5867483 | + | 720 | WP_010951640.1 | response regulator | - |
| EZZ80_RS27120 (EZZ80_27700) | 5867485..5868852 | + | 1368 | WP_010951639.1 | ATP-binding protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 159 a.a. Molecular weight: 18386.38 Da Isoelectric Point: 10.3522
>T119880 WP_020190010.1 NZ_CP036494:c5863995-5863519 [Pseudomonas putida]
MTGINPLAIARSPYIAHPDIWLTDIWIGDIFHPMLVRRDNTMRVITKAAVTKAIEVHGQWKAPLSLWLTTFDRATLRFES
FEQLRQTWATVSGWNVDRIPHSKLRPASRKGPLDIYVFDIKKNECRLIAWLNARTGTLYIKAILSHAEYDKWCRSDIR
MTGINPLAIARSPYIAHPDIWLTDIWIGDIFHPMLVRRDNTMRVITKAAVTKAIEVHGQWKAPLSLWLTTFDRATLRFES
FEQLRQTWATVSGWNVDRIPHSKLRPASRKGPLDIYVFDIKKNECRLIAWLNARTGTLYIKAILSHAEYDKWCRSDIR
Download Length: 477 bp
>T119880 NZ_CP036494:c5863995-5863519 [Pseudomonas putida]
TTGACGGGCATCAATCCATTGGCGATCGCCAGGTCACCGTACATCGCGCATCCAGATATCTGGTTGACAGATATCTGGAT
CGGAGATATTTTCCACCCTATGTTGGTGCGCCGGGACAACACAATGCGGGTCATAACGAAAGCGGCGGTTACCAAGGCGA
TTGAAGTCCACGGCCAGTGGAAAGCGCCCCTAAGCCTGTGGCTGACGACCTTCGACAGGGCGACGCTGCGGTTCGAATCT
TTTGAACAGTTGAGGCAGACGTGGGCCACTGTGTCTGGCTGGAATGTTGATCGCATCCCCCACTCAAAACTCAGGCCCGC
CAGCCGCAAAGGGCCGCTTGATATCTACGTGTTCGATATCAAGAAAAACGAATGCCGCCTGATCGCGTGGCTCAATGCGC
GAACGGGTACTCTCTACATCAAGGCCATTTTGTCGCACGCCGAGTACGACAAATGGTGCAGAAGCGATATCAGGTAG
TTGACGGGCATCAATCCATTGGCGATCGCCAGGTCACCGTACATCGCGCATCCAGATATCTGGTTGACAGATATCTGGAT
CGGAGATATTTTCCACCCTATGTTGGTGCGCCGGGACAACACAATGCGGGTCATAACGAAAGCGGCGGTTACCAAGGCGA
TTGAAGTCCACGGCCAGTGGAAAGCGCCCCTAAGCCTGTGGCTGACGACCTTCGACAGGGCGACGCTGCGGTTCGAATCT
TTTGAACAGTTGAGGCAGACGTGGGCCACTGTGTCTGGCTGGAATGTTGATCGCATCCCCCACTCAAAACTCAGGCCCGC
CAGCCGCAAAGGGCCGCTTGATATCTACGTGTTCGATATCAAGAAAAACGAATGCCGCCTGATCGCGTGGCTCAATGCGC
GAACGGGTACTCTCTACATCAAGGCCATTTTGTCGCACGCCGAGTACGACAAATGGTGCAGAAGCGATATCAGGTAG
Antitoxin
Download Length: 158 a.a. Molecular weight: 17229.67 Da Isoelectric Point: 4.4982
>AT119880 WP_004575922.1 NZ_CP036494:c5863477-5863004 [Pseudomonas putida]
MKRDKIEANGLDAFIANISPMLDGLNTQMATMAQLLAACHDPIKDDAELEARMALIDELYSHADSEGHAAARFAEMVADR
VYEYESESVLVPFASQAEALAFLLSDRGVKQKDLSAIATQSAVSEILNNKRKMTVAQIKGFAEFFSVPVEFFMHGVV
MKRDKIEANGLDAFIANISPMLDGLNTQMATMAQLLAACHDPIKDDAELEARMALIDELYSHADSEGHAAARFAEMVADR
VYEYESESVLVPFASQAEALAFLLSDRGVKQKDLSAIATQSAVSEILNNKRKMTVAQIKGFAEFFSVPVEFFMHGVV
Download Length: 474 bp
>AT119880 NZ_CP036494:c5863477-5863004 [Pseudomonas putida]
ATGAAGCGGGATAAAATCGAAGCCAATGGACTAGATGCCTTCATCGCTAATATTTCACCCATGCTCGATGGCCTGAACAC
TCAGATGGCAACCATGGCCCAGCTTCTAGCCGCCTGCCATGACCCCATCAAGGACGATGCCGAGCTTGAGGCACGCATGG
CCTTGATCGACGAGCTCTACTCCCATGCGGACAGCGAAGGCCACGCTGCGGCACGCTTTGCCGAGATGGTAGCGGACCGC
GTCTACGAGTATGAGAGTGAGTCTGTATTGGTGCCGTTCGCGAGCCAGGCCGAAGCGTTGGCCTTTCTGCTGTCGGATAG
GGGCGTGAAGCAGAAGGACCTGTCGGCGATAGCGACCCAGAGCGCGGTATCCGAGATTCTGAACAACAAGCGGAAGATGA
CGGTTGCCCAGATAAAGGGCTTTGCTGAGTTTTTCAGCGTACCGGTTGAGTTCTTCATGCATGGGGTGGTTTGA
ATGAAGCGGGATAAAATCGAAGCCAATGGACTAGATGCCTTCATCGCTAATATTTCACCCATGCTCGATGGCCTGAACAC
TCAGATGGCAACCATGGCCCAGCTTCTAGCCGCCTGCCATGACCCCATCAAGGACGATGCCGAGCTTGAGGCACGCATGG
CCTTGATCGACGAGCTCTACTCCCATGCGGACAGCGAAGGCCACGCTGCGGCACGCTTTGCCGAGATGGTAGCGGACCGC
GTCTACGAGTATGAGAGTGAGTCTGTATTGGTGCCGTTCGCGAGCCAGGCCGAAGCGTTGGCCTTTCTGCTGTCGGATAG
GGGCGTGAAGCAGAAGGACCTGTCGGCGATAGCGACCCAGAGCGCGGTATCCGAGATTCTGAACAACAAGCGGAAGATGA
CGGTTGCCCAGATAAAGGGCTTTGCTGAGTTTTTCAGCGTACCGGTTGAGTTCTTCATGCATGGGGTGGTTTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|