Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 6133444..6133949 Replicon chromosome
Accession NZ_CP036492
Organism Pseudomonas aeruginosa strain Paer4

Toxin (Protein)


Gene name parE Uniprot ID V6A7K8
Locus tag EZZ78_RS28340 Protein ID WP_003083773.1
Coordinates 6133668..6133949 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q9I707
Locus tag EZZ78_RS28335 Protein ID WP_003112628.1
Coordinates 6133444..6133671 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EZZ78_RS28310 (EZZ78_28970) 6128462..6129955 + 1494 WP_003101230.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -
EZZ78_RS28315 (EZZ78_28975) 6130124..6131551 + 1428 WP_003083784.1 GABA permease -
EZZ78_RS28320 (EZZ78_28980) 6131633..6131974 - 342 WP_003101229.1 zinc ribbon domain-containing protein YjdM -
EZZ78_RS28325 (EZZ78_28985) 6132047..6132547 - 501 WP_003112629.1 LEA type 2 family protein -
EZZ78_RS28330 (EZZ78_28990) 6132648..6133268 + 621 WP_003101226.1 hypothetical protein -
EZZ78_RS28335 (EZZ78_28995) 6133444..6133671 + 228 WP_003112628.1 CopG family ribbon-helix-helix protein Antitoxin
EZZ78_RS28340 (EZZ78_29000) 6133668..6133949 + 282 WP_003083773.1 type II toxin-antitoxin system toxin ParE Toxin
EZZ78_RS28345 (EZZ78_29005) 6134249..6135157 + 909 WP_003083769.1 LysR family transcriptional regulator -
EZZ78_RS28350 (EZZ78_29010) 6135189..6135599 - 411 WP_003101225.1 aegerolysin family protein -
EZZ78_RS28355 (EZZ78_29015) 6135779..6136513 - 735 WP_003115036.1 GntR family transcriptional regulator -
EZZ78_RS28360 (EZZ78_29020) 6136614..6137300 - 687 WP_003083762.1 FadR/GntR family transcriptional regulator -
EZZ78_RS28365 (EZZ78_29025) 6137349..6138698 - 1350 WP_003142411.1 C4-dicarboxylate transporter DctA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10462.19 Da        Isoelectric Point: 10.0435

>T119867 WP_003083773.1 NZ_CP036492:6133668-6133949 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp

>T119867 NZ_CP036492:6133668-6133949 [Pseudomonas aeruginosa]
ATGAGCCTGAAGTGGACCCGCAAGGCGGCCGCCGACCTGGACGCCATCTACGACCATTACGTCGTGCTGATCGGCCCGGA
AAAAGCTCTGAAAGCCGTTCAGGACATCGTCGAGCAGGTGAAACCGCTGCAGCAGGTAGCCAACCAGGGGGCAGGGCGGC
CCAGCGAGGTGCCAGGCGTACGCACCCTGACCCTGGAGCGCTGGCCGTTCAGCGCCCCGTTTCGGGTTAAAGGCAAGGAA
ATCCAGATTTTGCGCATCGACAGAGTCGAAATTACCCCCTGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8568.64 Da        Isoelectric Point: 5.5740

>AT119867 WP_003112628.1 NZ_CP036492:6133444-6133671 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHIEIEKRWGLQ

Download         Length: 228 bp

>AT119867 NZ_CP036492:6133444-6133671 [Pseudomonas aeruginosa]
ATGAGCACCGTAGTCTCGTTCCGCGCCGATGACGCCCTGGTCGCGGCCCTCGACGAACTGGCCCGCGCCACCCACCGCGA
CCGACCCTACCACCTGCGGCAGGCGCTCGCGCAGTACCTGGAAAGGCAGCAGTGGCAGGTCGCTGCCATCGATGAAGGCT
TGGCCGATGCCAATGCCGGTCGCCTGCTGGAACACATCGAGATCGAGAAGCGCTGGGGGCTGCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6XRW

Antitoxin

Source ID Structure
PDB 6XRW
AlphaFold DB Q9I707

References