Detailed information of TA system TA119860

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/-
• Location: 4372150..4372742
• Replicon: chromosome
• Accession: NZ_CP036491
• Organism: Bacteroides sp. A1C1

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: A0A4P6RLL2
• Locus tag: EYA81_RS18390
• Protein ID: WP_061412731.1
• Coordinates: 4372491..4372742 (-)
• Length: 84 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: A0A4P6RLY3
• Locus tag: EYA81_RS18385
• Protein ID: WP_061412725.1
• Coordinates: 4372150..4372494 (-)
• Length: 115 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EYA81_RS18360	4367485..4369998	+	2514	WP_131226295.1	DNA methylase N-4	-
EYA81_RS18365	4370402..4370947	+	546	WP_131226296.1	ASCH domain-containing protein	-
EYA81_RS18375	4371425..4371862	+	438	WP_131226298.1	hypothetical protein	-
EYA81_RS18380	4371874..4372143	-	270	WP_061412722.1	hypothetical protein	-
EYA81_RS18385	4372150..4372494	-	345	WP_061412725.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
EYA81_RS18390	4372491..4372742	-	252	WP_061412731.1	type II toxin-antitoxin system HicA family toxin	Toxin
EYA81_RS18395	4372795..4373106	-	312	WP_081106202.1	helix-turn-helix domain-containing protein	-
EYA81_RS18400	4373359..4373541	+	183	WP_061412734.1	hypothetical protein	-
EYA81_RS18405	4373552..4373806	+	255	WP_131226300.1	hypothetical protein	-
EYA81_RS18410	4373843..4374043	+	201	WP_057279906.1	hypothetical protein	-
EYA81_RS18415	4374087..4374284	+	198	WP_131226302.1	hypothetical protein	-
EYA81_RS18420	4374297..4374503	+	207	WP_081106205.1	DUF3873 family protein	-
EYA81_RS18425	4374679..4375068	+	390	WP_119961662.1	ASCH domain-containing protein	-
EYA81_RS18430	4375272..4375949	+	678	WP_131226303.1	phosphoadenosine phosphosulfate reductase family protein	-
EYA81_RS18435	4376170..4376910	+	741	WP_131226305.1	ParB N-terminal domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	4350747..4408226	57479

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (20-74)

Antitoxin

• Uncharacterised protein family HicB (56-105)

Sequences

Toxin

Protein

• Length: 84 a.a.
• Molecular weight: 9572.16 Da
• Isoelectric Point: 10.5589

>T119860 WP_061412731.1 NZ_CP036491:c4372742-4372491 [Bacteroides sp. A1C1]
MGTKEKLIERFKSQPKDFNWDELVRLFSIFGYKIDNKGKTSGSRVIFAKGESSYTAHKPHPGSIVKGYVMKQVFEFLTKN
KLI

Nucleotide

• Length: 252 bp

>T119860 NZ_CP036491:c4372742-4372491 [Bacteroides sp. A1C1]
ATGGGTACAAAAGAGAAGTTGATAGAACGCTTTAAAAGCCAGCCAAAAGATTTTAATTGGGATGAGCTTGTACGCTTGTT
CTCCATTTTCGGATATAAGATAGATAACAAAGGAAAAACAAGTGGGTCACGTGTCATTTTCGCAAAAGGGGAAAGCTCGT
ACACTGCGCATAAGCCACATCCAGGAAGTATCGTAAAAGGGTATGTAATGAAACAAGTATTTGAATTTCTGACTAAAAAT
AAATTAATATGA

Antitoxin

Protein

• Length: 115 a.a.
• Molecular weight: 12515.36 Da
• Isoelectric Point: 4.8722

>AT119860 WP_061412725.1 NZ_CP036491:c4372494-4372150 [Bacteroides sp. A1C1]
MKTLTYKGYIGSIEISDEDNCLFGKVLDLPKDTMISYEGETVSELKEDFKGAVDDYIAYCKEAGITPRKSYSGSLNIRIS
PEVHSKIAILAQQAGISINAFIKSAVEKQVATML

Nucleotide

• Length: 345 bp

>AT119860 NZ_CP036491:c4372494-4372150 [Bacteroides sp. A1C1]
ATGAAAACATTGACTTACAAAGGTTACATAGGAAGTATTGAGATAAGCGATGAAGATAATTGCCTATTTGGAAAAGTCCT
TGATTTGCCAAAAGATACAATGATTTCGTATGAAGGTGAAACTGTATCTGAATTGAAAGAGGATTTTAAAGGAGCTGTGG
ATGATTATATAGCATATTGTAAGGAAGCCGGAATTACACCGCGTAAAAGTTATTCTGGTTCCCTGAACATACGAATTTCC
CCAGAGGTACATAGCAAAATTGCCATTCTCGCCCAACAGGCTGGAATATCAATAAACGCTTTTATTAAATCAGCCGTAGA
AAAGCAAGTTGCAACTATGTTATAA

Structures

Toxin

• AlphaFold DB: A0A4P6RLL2

Antitoxin

• AlphaFold DB: A0A4P6RLY3