Detailed information of TA system TA119857

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): pasABC/RelE-HTH
• Location: 24345..24837
• Replicon: plasmid pER79ag33
• Accession: NZ_CP036467
• Organism: Zymomonas mobilis strain ER79ag

Toxin (Protein)

• Gene name: pasB
• Uniprot ID: -
• Locus tag: EWS78_RS09300
• Protein ID: WP_062339561.1
• Coordinates: 24345..24629 (-)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: pasA
• Uniprot ID: -
• Locus tag: EWS78_RS09305
• Protein ID: WP_062339563.1
• Coordinates: 24613..24837 (-)
• Length: 75 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EWS78_RS09290	22216..23288	-	1073	Protein_23	IS701 family transposase	-
EWS78_RS09295	23410..24140	+	731	Protein_24	IS5 family transposase	-
EWS78_RS09300	24345..24629	-	285	WP_062339561.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
EWS78_RS09305	24613..24837	-	225	WP_062339563.1	TraY domain-containing protein	Antitoxin
EWS78_RS09310	25180..26685	-	1506	WP_062339565.1	helix-turn-helix domain-containing protein	-
EWS78_RS09315	26792..27043	-	252	WP_062339567.1	DUF2312 domain-containing protein	-
EWS78_RS09320	27168..27485	-	318	WP_062339569.1	hypothetical protein	-
EWS78_RS09325	27889..28377	+	489	WP_062339571.1	hypothetical protein	-
EWS78_RS09330	28670..28864	-	195	WP_151457903.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..33007	33007

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-88)

Antitoxin

• Relaxosome protein TraY (4-49)

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 10895.82 Da
• Isoelectric Point: 10.9192

>T119857 WP_062339561.1 NZ_CP036467:c24629-24345 [Zymomonas mobilis]
MAWKIEFDPAAQKELKKLGTQPAKRILRFLSERLALADDPRSFGAALKGTTLGNLWKYRIGDYRIIADIEDNVMRILVVR
IGNRREIYKKAVRH

Nucleotide

• Length: 285 bp

>T119857 NZ_CP036467:c24629-24345 [Zymomonas mobilis]
ATGGCTTGGAAAATTGAATTCGATCCAGCCGCGCAAAAAGAGTTGAAAAAATTAGGAACACAGCCAGCTAAGCGGATCTT
AAGATTTTTATCTGAACGATTGGCCTTGGCTGATGACCCAAGGTCATTTGGGGCAGCTTTAAAGGGAACAACACTAGGTA
ATTTATGGAAGTATCGAATTGGTGATTACCGCATCATTGCAGATATTGAAGATAATGTGATGCGGATTTTGGTTGTCCGA
ATTGGTAATAGAAGAGAAATTTATAAAAAAGCCGTCAGGCATTGA

Antitoxin

Protein

• Length: 75 a.a.
• Molecular weight: 8398.60 Da
• Isoelectric Point: 4.8172

>AT119857 WP_062339563.1 NZ_CP036467:c24837-24613 [Zymomonas mobilis]
MLAIRLPEEIEDRLSALANATGRTKTFYAREAILHHLEELEDIYLAEARAVKIRSGQTKTVPLENIMAEYGLEN

Nucleotide

• Length: 225 bp

>AT119857 NZ_CP036467:c24837-24613 [Zymomonas mobilis]
ATGTTAGCGATCAGACTACCAGAAGAAATAGAAGACCGTTTAAGTGCATTAGCCAATGCAACAGGTAGAACTAAGACTTT
CTATGCCAGAGAAGCCATACTTCATCATTTGGAAGAGCTTGAGGATATTTATCTAGCAGAAGCGCGCGCAGTTAAAATCC
GTTCCGGCCAGACTAAGACTGTCCCATTAGAAAATATTATGGCCGAATATGGCTTGGAAAATTGA