Detailed information of TA system TA119853

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): pasABC/RelE-HTH
• Location: 24344..24836
• Replicon: plasmid pZM33o
• Accession: NZ_CP036463
• Organism: Zymomonas mobilis strain ZM4*

Toxin (Protein)

• Gene name: pasB
• Uniprot ID: -
• Locus tag: EWS79_RS09285
• Protein ID: WP_062339561.1
• Coordinates: 24344..24628 (-)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: pasA
• Uniprot ID: -
• Locus tag: EWS79_RS09290
• Protein ID: WP_062339563.1
• Coordinates: 24612..24836 (-)
• Length: 75 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EWS79_RS09275	22216..23288	-	1073	Protein_23	IS701 family transposase	-
EWS79_RS09280	23410..24139	+	730	Protein_24	IS5 family transposase	-
EWS79_RS09285	24344..24628	-	285	WP_062339561.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
EWS79_RS09290	24612..24836	-	225	WP_062339563.1	TraY domain-containing protein	Antitoxin
EWS79_RS09295	25179..26684	-	1506	WP_062339565.1	helix-turn-helix domain-containing protein	-
EWS79_RS09300	26791..27042	-	252	WP_062339567.1	DUF2312 domain-containing protein	-
EWS79_RS09305	27167..27484	-	318	WP_062339569.1	hypothetical protein	-
EWS79_RS09310	27888..28376	+	489	WP_062339571.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..33006	33006

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-88)

Antitoxin

• Relaxosome protein TraY (4-49)

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 10895.82 Da
• Isoelectric Point: 10.9192

>T119853 WP_062339561.1 NZ_CP036463:c24628-24344 [Zymomonas mobilis]
MAWKIEFDPAAQKELKKLGTQPAKRILRFLSERLALADDPRSFGAALKGTTLGNLWKYRIGDYRIIADIEDNVMRILVVR
IGNRREIYKKAVRH

Nucleotide

• Length: 285 bp

>T119853 NZ_CP036463:c24628-24344 [Zymomonas mobilis]
ATGGCTTGGAAAATTGAATTCGATCCAGCCGCGCAAAAAGAGTTGAAAAAATTAGGAACACAGCCAGCTAAGCGGATCTT
AAGATTTTTATCTGAACGATTGGCCTTGGCTGATGACCCAAGGTCATTTGGGGCAGCTTTAAAGGGAACAACACTAGGTA
ATTTATGGAAGTATCGAATTGGTGATTACCGCATCATTGCAGATATTGAAGATAATGTGATGCGGATTTTGGTTGTCCGA
ATTGGTAATAGAAGAGAAATTTATAAAAAAGCCGTCAGGCATTGA

Antitoxin

Protein

• Length: 75 a.a.
• Molecular weight: 8398.60 Da
• Isoelectric Point: 4.8172

>AT119853 WP_062339563.1 NZ_CP036463:c24836-24612 [Zymomonas mobilis]
MLAIRLPEEIEDRLSALANATGRTKTFYAREAILHHLEELEDIYLAEARAVKIRSGQTKTVPLENIMAEYGLEN

Nucleotide

• Length: 225 bp

>AT119853 NZ_CP036463:c24836-24612 [Zymomonas mobilis]
ATGTTAGCGATCAGACTACCAGAAGAAATAGAAGACCGTTTAAGTGCATTAGCCAATGCAACAGGTAGAACTAAGACTTT
CTATGCCAGAGAAGCCATACTTCATCATTTGGAAGAGCTTGAGGATATTTATCTAGCAGAAGCGCGCGCAGTTAAAATCC
GTTCCGGCCAGACTAAGACTGTCCCATTAGAAAATATTATGGCCGAATATGGCTTGGAAAATTGA