Detailed information of TA system TA119846

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazEF/PemK(toxin)
• Location: 4616958..4617544
• Replicon: chromosome
• Accession: NZ_CP036455
• Organism: Streptomonospora sp. M2

Toxin (Protein)

• Gene name: mazF
• Uniprot ID: -
• Locus tag: EKD16_RS19370
• Protein ID: WP_131099894.1
• Coordinates: 4616958..4617305 (-)
• Length: 116 a.a.

Antitoxin (Protein)

• Gene name: mazE
• Uniprot ID: -
• Locus tag: EKD16_RS19375
• Protein ID: WP_131099898.1
• Coordinates: 4617299..4617544 (-)
• Length: 82 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EKD16_RS19355	4612446..4613519	-	1074	WP_131099889.1	Gfo/Idh/MocA family oxidoreductase	-
EKD16_RS19360	4613727..4614035	+	309	WP_131102793.1	hypothetical protein	-
EKD16_RS19365	4614430..4616841	-	2412	WP_131099891.1	endopeptidase La	-
EKD16_RS19370	4616958..4617305	-	348	WP_131099894.1	type II toxin-antitoxin system PemK/MazF family toxin	Toxin
EKD16_RS19375	4617299..4617544	-	246	WP_131099898.1	ribbon-helix-helix protein, CopG family	Antitoxin
EKD16_RS19380	4617617..4618273	-	657	WP_131099901.1	response regulator transcription factor	-
EKD16_RS19385	4618270..4619478	-	1209	WP_131102794.1	sensor histidine kinase	-
EKD16_RS19390	4619730..4621112	-	1383	WP_131099904.1	MHS family MFS transporter	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (4-112)

Antitoxin

• Ribbon-helix-helix protein, CopG (5-39)

Sequences

Toxin

Protein

• Length: 116 a.a.
• Molecular weight: 11846.78 Da
• Isoelectric Point: 7.9863

>T119846 WP_131099894.1 NZ_CP036455:c4617305-4616958 [Streptomonospora sp. M2]
VVIRRGGIYWVDLGGPVGSRPGKERPVLVVQSEAFNASGLATALVVVLTSNTRLAAMPGNVFVPSVAGCLPKDSVVNVTA
VATVGKDELSGPVGVLPQDIMDDVDRGLRRVLGLA

Nucleotide

• Length: 348 bp

>T119846 NZ_CP036455:c4617305-4616958 [Streptomonospora sp. M2]
GTGGTGATTCGCCGTGGCGGGATCTATTGGGTCGACTTGGGGGGTCCGGTAGGGAGTCGTCCAGGAAAAGAACGGCCGGT
GCTGGTCGTCCAGTCCGAGGCGTTCAATGCCAGTGGGCTCGCTACGGCCTTGGTCGTCGTGCTCACGTCCAACACGAGAC
TCGCCGCGATGCCGGGTAACGTCTTCGTCCCCTCGGTCGCCGGTTGCTTGCCCAAGGACTCGGTCGTCAACGTCACCGCC
GTGGCGACGGTGGGCAAGGACGAACTGTCGGGGCCGGTGGGGGTGCTTCCCCAAGACATCATGGACGACGTCGACAGAGG
ACTCCGGCGGGTGCTCGGGCTGGCCTAG

Antitoxin

Protein

• Length: 82 a.a.
• Molecular weight: 8857.65 Da
• Isoelectric Point: 4.1844

>AT119846 WP_131099898.1 NZ_CP036455:c4617544-4617299 [Streptomonospora sp. M2]
MKTAISIPDEIFERVEQRAADLHVSRSEFFSRAAQSYLDELDSAELSRRIDEAIALSGEDDSNAAAAAAGRRSILDASGE
W

Nucleotide

• Length: 246 bp

>AT119846 NZ_CP036455:c4617544-4617299 [Streptomonospora sp. M2]
ATGAAGACCGCGATATCGATTCCAGATGAGATCTTCGAGCGCGTGGAACAGCGTGCTGCCGACCTGCATGTGAGTAGGTC
CGAATTCTTTTCCCGCGCCGCGCAATCCTACTTGGACGAGTTGGACAGCGCGGAGTTGTCGCGTCGAATCGACGAAGCCA
TCGCCCTCTCCGGTGAGGACGATTCCAACGCTGCTGCGGCCGCCGCGGGGCGTCGCAGCATTCTCGATGCGTCGGGTGAG
TGGTGA