Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 3773135..3773766 Replicon chromosome
Accession NZ_CP036455
Organism Streptomonospora sp. M2

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag EKD16_RS15850 Protein ID WP_131099101.1
Coordinates 3773135..3773548 (-) Length 138 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag EKD16_RS15855 Protein ID WP_131099102.1
Coordinates 3773545..3773766 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EKD16_RS15830 3769840..3770172 - 333 WP_131099098.1 hypothetical protein -
EKD16_RS15835 3770255..3771178 - 924 WP_131099099.1 CRISPR system precrRNA processing endoribonuclease RAMP protein Cas6 -
EKD16_RS15840 3771390..3771665 + 276 WP_131099100.1 hypothetical protein -
EKD16_RS15845 3771856..3773067 + 1212 WP_131102628.1 hypothetical protein -
EKD16_RS15850 3773135..3773548 - 414 WP_131099101.1 PIN domain-containing protein Toxin
EKD16_RS15855 3773545..3773766 - 222 WP_131099102.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
EKD16_RS15860 3774067..3774462 - 396 WP_131102630.1 RidA family protein -
EKD16_RS15865 3774499..3775665 - 1167 WP_131102632.1 MFS transporter -
EKD16_RS15870 3775868..3776347 - 480 WP_131102633.1 Rrf2 family transcriptional regulator -
EKD16_RS15875 3776372..3776548 + 177 Protein_3150 type II toxin-antitoxin system RelE/ParE family toxin -
EKD16_RS15880 3776665..3776964 + 300 WP_131102636.1 hypothetical protein -
EKD16_RS15885 3777203..3778294 - 1092 WP_131099103.1 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-122)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(4-46)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 15560.69 Da        Isoelectric Point: 6.6291

>T119845 WP_131099101.1 NZ_CP036455:c3773548-3773135 [Streptomonospora sp. M2]
VIRYLIDTSALWRVMREEKCRHAWSSVIDAGAIGSCGPQRAEFRRSARDLDHYEQIDDMFSVLYPDAPVPKSAWQWIEST
QYRLLRKGVLRCASALDLLISATAAHHGLTVLHDDNDFGAIARCVSDLKERSIYDLP

Download         Length: 414 bp

>T119845 NZ_CP036455:c3773548-3773135 [Streptomonospora sp. M2]
GTGATCCGCTATCTCATAGACACCTCGGCGTTGTGGCGCGTCATGAGAGAGGAGAAGTGCCGACATGCGTGGTCCTCGGT
GATCGATGCGGGGGCGATTGGCTCCTGTGGCCCTCAGCGGGCGGAATTTCGCAGGTCGGCCCGGGATCTCGACCACTACG
AGCAGATCGACGACATGTTCTCGGTCCTGTATCCGGACGCTCCAGTCCCGAAGAGCGCTTGGCAGTGGATTGAGTCGACG
CAGTACCGGCTGTTGCGGAAGGGAGTGCTACGGTGCGCATCCGCCCTGGATCTACTCATCAGCGCAACGGCGGCACATCA
CGGTTTGACGGTGCTCCACGACGACAACGACTTCGGGGCTATCGCCCGTTGTGTTTCTGACCTCAAGGAACGGTCTATCT
ACGACCTTCCGTAG

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8659.69 Da        Isoelectric Point: 5.1816

>AT119845 WP_131099102.1 NZ_CP036455:c3773766-3773545 [Streptomonospora sp. M2]
MALTQIDLDVEALAESMRLSGLTTKKDMVNEALREYVARHRRIEALEHYARLSAEWDYEGWRRRHNAEKEAEE

Download         Length: 222 bp

>AT119845 NZ_CP036455:c3773766-3773545 [Streptomonospora sp. M2]
ATGGCGTTGACTCAGATCGATCTGGACGTGGAAGCACTGGCGGAGTCCATGCGCCTGTCAGGGCTGACTACTAAGAAGGA
CATGGTGAACGAAGCTCTGCGCGAGTATGTCGCACGCCATCGGCGCATCGAAGCTCTCGAACATTATGCGCGCCTCTCAG
CCGAGTGGGACTACGAAGGATGGCGTCGTCGTCATAACGCGGAGAAGGAAGCCGAGGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References