Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4758582..4759239 Replicon chromosome
Accession NZ_CP036450
Organism Klebsiella pneumoniae strain KPNIH45

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag C3377_RS25475 Protein ID WP_002916310.1
Coordinates 4758582..4758992 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag C3377_RS25480 Protein ID WP_002916312.1
Coordinates 4758973..4759239 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C3377_RS25455 4754582..4756315 - 1734 WP_004151783.1 single-stranded-DNA-specific exonuclease RecJ -
C3377_RS25460 4756321..4757034 - 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
C3377_RS25465 4757057..4757953 - 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
C3377_RS25470 4758054..4758575 + 522 WP_002916308.1 flavodoxin FldB -
C3377_RS25475 4758582..4758992 - 411 WP_002916310.1 protein YgfX Toxin
C3377_RS25480 4758973..4759239 - 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
C3377_RS25485 4759485..4760468 + 984 WP_002916313.1 tRNA-modifying protein YgfZ -
C3377_RS25490 4760619..4761278 - 660 WP_002916317.1 hemolysin III family protein -
C3377_RS25495 4761442..4761753 - 312 WP_002916319.1 N(4)-acetylcytidine aminohydrolase -
C3377_RS25500 4761803..4762531 + 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
C3377_RS25505 4762650..4764083 + 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T119836 WP_002916310.1 NZ_CP036450:c4758992-4758582 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T119836 NZ_CP036450:c4758992-4758582 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAAATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT119836 WP_002916312.1 NZ_CP036450:c4759239-4758973 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT119836 NZ_CP036450:c4759239-4758973 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References