Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 664452..664968 Replicon chromosome
Accession NZ_CP036442
Organism Klebsiella pneumoniae strain ABFPV

Toxin (Protein)


Gene name relE Uniprot ID A0A2A2BGN7
Locus tag WN05_RS03320 Protein ID WP_009486548.1
Coordinates 664684..664968 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag WN05_RS03315 Protein ID WP_002886901.1
Coordinates 664452..664694 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
WN05_RS03300 660480..661220 + 741 WP_009486551.1 KDGP aldolase family protein -
WN05_RS03305 661287..662441 + 1155 WP_020316350.1 lactonase family protein -
WN05_RS03310 662464..664374 + 1911 WP_009486549.1 BglG family transcription antiterminator -
WN05_RS03315 664452..664694 + 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
WN05_RS03320 664684..664968 + 285 WP_009486548.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
WN05_RS03325 664972..665436 - 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
WN05_RS03330 665744..667882 - 2139 WP_002886904.1 anaerobic ribonucleoside-triphosphate reductase -
WN05_RS03335 668239..668982 - 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
WN05_RS28290 668985..669158 - 174 WP_002886906.1 hypothetical protein -
WN05_RS03340 669243..669551 + 309 WP_012737232.1 PTS sugar transporter subunit IIB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.4951

>T119805 WP_009486548.1 NZ_CP036442:664684-664968 [Klebsiella pneumoniae]
MTYELEFDPRARREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T119805 NZ_CP036442:664684-664968 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCAGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGACCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT119805 WP_002886901.1 NZ_CP036442:664452-664694 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT119805 NZ_CP036442:664452-664694 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCAGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A2BGN7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References