Detailed information of TA system TA119802

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 77792..78327
• Replicon: plasmid unnamed1
• Accession: NZ_CP036439
• Organism: Klebsiella pneumoniae strain ABFQB

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A6M4NRI2
• Locus tag: WN11_RS26465
• Protein ID: WP_032693963.1
• Coordinates: 77792..78079 (-)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: WN11_RS26470
• Protein ID: WP_032693964.1
• Coordinates: 78076..78327 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
WN11_RS26435	73382..74014	+	633	WP_080884176.1	ParA family protein	-
WN11_RS26440	74014..74388	+	375	WP_088903436.1	hypothetical protein	-
WN11_RS26445	74628..75602	+	975	WP_080884175.1	StbA family protein	-
WN11_RS26450	75606..75998	+	393	WP_080884174.1	plasmid partitioning/stability family protein	-
WN11_RS26455	76274..76774	-	501	WP_080884173.1	hypothetical protein	-
WN11_RS26460	77521..77709	-	189	WP_080884172.1	hypothetical protein	-
WN11_RS26465	77792..78079	-	288	WP_032693963.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
WN11_RS26470	78076..78327	-	252	WP_032693964.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
WN11_RS26475	78494..79768	-	1275	WP_080884171.1	Y-family DNA polymerase	-
WN11_RS26480	79768..80193	-	426	WP_032693966.1	translesion error-prone DNA polymerase V autoproteolytic subunit	-
WN11_RS26485	80403..80633	+	231	WP_032693967.1	hypothetical protein	-
WN11_RS26490	81068..81301	+	234	WP_080884170.1	hypothetical protein	-
WN11_RS26495	81298..81633	+	336	WP_080884169.1	hypothetical protein	-
WN11_RS26505	82017..82718	+	702	WP_080884168.1	DNA methylase	-
WN11_RS26510	82718..82939	+	222	WP_032693969.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..115291	115291

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-86)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 11133.12 Da
• Isoelectric Point: 10.2246

>T119802 WP_032693963.1 NZ_CP036439:c78079-77792 [Klebsiella pneumoniae]
MTYTVKFREDALKEWQKLDKAIQQQFAKKLKKCCDEPHIPSAKLRGIKDCYKIKLRASGFRLVYQVIDDQLIIAVVAVGK
RERSDVYNLASERMR

Nucleotide

• Length: 288 bp

>T119802 NZ_CP036439:c78079-77792 [Klebsiella pneumoniae]
ATGACTTATACGGTCAAATTCAGGGAAGATGCGCTGAAGGAATGGCAAAAGCTGGATAAGGCCATTCAGCAACAGTTTGC
GAAGAAGCTGAAGAAGTGCTGTGACGAACCACATATCCCCTCAGCAAAGCTGAGAGGGATAAAGGACTGCTATAAAATTA
AACTTCGCGCGTCAGGCTTTCGTCTGGTCTATCAGGTAATAGATGATCAACTGATTATTGCTGTTGTGGCTGTCGGAAAG
CGTGAACGTAGTGACGTGTACAATCTGGCCAGCGAACGGATGAGGTAA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9202.49 Da
• Isoelectric Point: 4.0785

>AT119802 WP_032693964.1 NZ_CP036439:c78327-78076 [Klebsiella pneumoniae]
MPNIILSDTSASISELKKNPMATVSAGDGFPVAILNRNQPAFYCIPAELYEKMLDALDDQELAKLVSERSNQRLLDVDLD
TYL

Nucleotide

• Length: 252 bp

>AT119802 NZ_CP036439:c78327-78076 [Klebsiella pneumoniae]
ATGCCCAACATTATTCTGAGTGACACAAGCGCGAGCATCAGCGAACTTAAAAAAAACCCGATGGCGACGGTCAGTGCCGG
CGACGGCTTCCCGGTCGCTATTCTGAACCGTAATCAGCCCGCTTTTTACTGCATCCCGGCAGAGCTTTACGAGAAGATGC
TCGATGCCCTGGATGATCAGGAACTGGCAAAGCTGGTTTCAGAACGCAGTAACCAGCGACTGCTTGACGTGGATCTGGAC
ACATATCTATGA

Structures

Toxin

• AlphaFold DB: A0A6M4NRI2