Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3303794..3304413 Replicon chromosome
Accession NZ_CP036438
Organism Klebsiella pneumoniae strain ABFQB

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag WN11_RS16355 Protein ID WP_002892050.1
Coordinates 3303794..3304012 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag WN11_RS16360 Protein ID WP_002892066.1
Coordinates 3304039..3304413 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
WN11_RS16325 3299841..3300104 + 264 WP_002892011.1 type B 50S ribosomal protein L31 -
WN11_RS16330 3300104..3300244 + 141 WP_002892018.1 type B 50S ribosomal protein L36 -
WN11_RS16335 3300241..3300939 - 699 WP_004893822.1 GNAT family N-acetyltransferase -
WN11_RS16340 3301040..3302491 + 1452 WP_002892023.1 PLP-dependent aminotransferase family protein -
WN11_RS16345 3302466..3302936 - 471 WP_002892026.1 YlaC family protein -
WN11_RS27705 3302957..3303097 + 141 WP_032409038.1 hypothetical protein -
WN11_RS16350 3303069..3303635 - 567 WP_002892030.1 maltose O-acetyltransferase -
WN11_RS16355 3303794..3304012 - 219 WP_002892050.1 hemolysin expression modulator Hha Toxin
WN11_RS16360 3304039..3304413 - 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
WN11_RS16365 3304899..3308045 - 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
WN11_RS16370 3308068..3309261 - 1194 WP_004177236.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T119798 WP_002892050.1 NZ_CP036438:c3304012-3303794 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T119798 NZ_CP036438:c3304012-3303794 [Klebsiella pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACTTCTGTCTGGAAATTTATCCGCTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT119798 WP_002892066.1 NZ_CP036438:c3304413-3304039 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT119798 NZ_CP036438:c3304413-3304039 [Klebsiella pneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References