119796

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) ykfI-yeeU/CbtA-CbeA
Location 2669896..2670601 Replicon chromosome
Accession NZ_CP036438
Organism Klebsiella pneumoniae strain ABFQB

Toxin (Protein)


Gene name ykfI Uniprot ID -
Locus tag WN11_RS13280 Protein ID WP_131138753.1
Coordinates 2670260..2670601 (+) Length 114 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag WN11_RS13275 Protein ID WP_174719387.1
Coordinates 2669896..2670225 (+) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
WN11_RS13245 2665104..2666201 + 1098 WP_131138748.1 hypothetical protein -
WN11_RS13250 2666300..2667193 + 894 WP_131138749.1 50S ribosome-binding GTPase -
WN11_RS13255 2667479..2668156 + 678 WP_131138750.1 hypothetical protein -
WN11_RS13260 2668252..2669073 + 822 WP_165488507.1 DUF945 domain-containing protein -
WN11_RS13265 2669144..2669617 + 474 WP_107357770.1 DNA repair protein RadC -
WN11_RS13270 2669633..2669854 + 222 WP_131138752.1 DUF987 family protein -
WN11_RS13275 2669896..2670225 + 330 WP_174719387.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
WN11_RS13280 2670260..2670601 + 342 WP_131138753.1 TA system toxin CbtA family protein Toxin
WN11_RS13285 2671019..2671129 + 111 Protein_2502 DUF4102 domain-containing protein -
WN11_RS13290 2671142..2671276 - 135 Protein_2503 transposase -
WN11_RS13295 2671422..2671685 - 264 WP_004192273.1 hypothetical protein -
WN11_RS13300 2671675..2672802 - 1128 WP_023325431.1 PAAR domain-containing protein -
WN11_RS13310 2673456..2674555 + 1100 Protein_2506 IS3 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-109)

Antitoxin

Antitoxin CbeA

(8-108)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12824.85 Da        Isoelectric Point: 6.2161

>T119796 WP_131138753.1 NZ_CP036438:2670260-2670601 [Klebsiella pneumoniae]
MNTLPAINQRAVQLCPSPVTIWQTLLTRLLEQHYGLALNDTPFGDESVIQEHIDAGITLVDAVNFLVEKYELVRIDRRAL
GWLEPSPYLRAVDILRMRRDMGLLRGSNHTAAM

Download         Length: 342 bp

>T119796 NZ_CP036438:2670260-2670601 [Klebsiella pneumoniae]
ATGAATACTTTACCTGCAATAAACCAGCGGGCTGTTCAGTTATGCCCATCGCCCGTAACTATCTGGCAAACGTTGCTAAC
TCGTTTACTGGAACAACACTACGGGCTGGCGCTGAACGACACACCGTTCGGTGATGAAAGCGTCATTCAGGAACATATCG
ATGCCGGTATTACACTCGTTGATGCTGTTAACTTCTTGGTGGAAAAGTACGAGCTGGTTCGTATCGACCGCAGGGCGTTA
GGCTGGTTGGAACCATCTCCATACTTGCGAGCTGTAGACATTCTGCGAATGCGTCGGGACATGGGGCTGTTGCGAGGCAG
CAACCACACTGCAGCAATGTGA

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 12268.00 Da        Isoelectric Point: 5.5062

>AT119796 WP_174719387.1 NZ_CP036438:2669896-2670225 [Klebsiella pneumoniae]
VNDDTAEPWWGLSRNVIPCFGARLVQEGNRLHYLADRASLTGQFNEADLLHLDQAFPVLLKQMELMLTCGELNPRHQHCV
TLYAKGLTCEADTLGSCGYVYIAIYPTQR

Download         Length: 330 bp

>AT119796 NZ_CP036438:2669896-2670225 [Klebsiella pneumoniae]
GTGAATGATGATACTGCTGAGCCCTGGTGGGGTTTGAGTCGTAACGTCATCCCTTGTTTTGGCGCACGTCTGGTTCAGGA
AGGTAATCGCCTGCATTACCTGGCTGACCGCGCCAGCTTAACAGGCCAGTTCAATGAAGCGGATTTACTCCATCTTGACC
AGGCGTTCCCGGTACTGCTGAAGCAGATGGAGCTCATGCTTACCTGCGGCGAACTGAATCCACGACACCAGCACTGCGTC
ACGCTTTATGCGAAGGGGCTAACCTGCGAAGCTGATACGCTGGGCTCCTGCGGTTACGTTTATATCGCCATTTACCCCAC
ACAACGCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References