Detailed information of TA system TA119795

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yjhX-yjhQ/YjhX-GNAT
• Location: 2635695..2636515
• Replicon: chromosome
• Accession: NZ_CP036438
• Organism: Klebsiella pneumoniae strain ABFQB

Toxin (Protein)

• Gene name: yjhX
• Uniprot ID: -
• Locus tag: WN11_RS13110
• Protein ID: WP_131138733.1
• Coordinates: 2636258..2636515 (-)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: yjhQ
• Uniprot ID: -
• Locus tag: WN11_RS13105
• Protein ID: WP_131138732.1
• Coordinates: 2635695..2636246 (-)
• Length: 184 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
WN11_RS13090	2634094..2634471	-	378	WP_131138729.1	VOC family protein	-
WN11_RS13095	2634519..2634770	-	252	WP_131138730.1	hypothetical protein	-
WN11_RS13100	2634897..2635643	-	747	WP_131138731.1	class I SAM-dependent methyltransferase	-
WN11_RS13105	2635695..2636246	-	552	WP_131138732.1	N-acetyltransferase	Antitoxin
WN11_RS13110	2636258..2636515	-	258	WP_131138733.1	YjhX family toxin	Toxin
WN11_RS13115	2636855..2637331	-	477	WP_075052325.1	GNAT family N-acetyltransferase	-
WN11_RS13120	2637464..2637868	-	405	WP_131138734.1	VOC family protein	-
WN11_RS13125	2637882..2639138	-	1257	WP_131138735.1	MFS transporter	-
WN11_RS13130	2639177..2639749	-	573	WP_131138799.1	DUF1349 domain-containing protein	-
WN11_RS13135	2639790..2640608	-	819	WP_131138736.1	GNAT family N-acetyltransferase	-
WN11_RS13140	2640669..2641103	-	435	WP_131138737.1	VOC family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	2628616..2649458	20842

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Putative toxin of bacterial toxin-antitoxin pair (1-85)

Antitoxin

• GNAT domain (19-121)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9522.04 Da
• Isoelectric Point: 11.1381

>T119795 WP_131138733.1 NZ_CP036438:c2636515-2636258 [Klebsiella pneumoniae]
MNLSRQEQRTLHVLAKGGRIAHVRDASGRVTAVECYSREGLLLSDCTLAVFKKLKTKKLIKSVNGQPYRINTTGLNNVRA
QLDNR

Nucleotide

• Length: 258 bp

>T119795 NZ_CP036438:c2636515-2636258 [Klebsiella pneumoniae]
ATGAATTTATCCCGTCAGGAACAACGTACCTTACACGTTCTCGCCAAAGGTGGACGTATTGCGCACGTCCGCGATGCTTC
AGGCCGCGTCACTGCCGTTGAATGCTACAGCCGCGAAGGGCTGTTGCTGAGCGACTGCACGCTCGCCGTCTTCAAAAAAC
TCAAAACCAAAAAACTTATCAAGTCCGTCAATGGTCAGCCCTATCGTATCAACACTACCGGGCTGAATAACGTTCGCGCT
CAGCTCGATAATCGCTAA

Antitoxin

Protein

• Length: 184 a.a.
• Molecular weight: 20301.24 Da
• Isoelectric Point: 6.4174

>AT119795 WP_131138732.1 NZ_CP036438:c2636246-2635695 [Klebsiella pneumoniae]
MTAHHFTFHITDESDASDIREVETRAFGFSKEADLTASLLEDESARPALSLLARHEGKAVGHILFTRATFKGEMDSPLIH
ILAPLAVIPEYQGMGVGGLLIRTGIEHLRQMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEQHKACWMLQPLTA
QPINVTGQIQCAQALMKPEHWRE

Nucleotide

• Length: 552 bp

>AT119795 NZ_CP036438:c2636246-2635695 [Klebsiella pneumoniae]
ATGACAGCACACCACTTCACTTTTCATATCACCGACGAAAGTGATGCCAGTGATATCCGGGAAGTCGAAACCCGCGCATT
TGGCTTCAGCAAAGAAGCCGATTTAACGGCCTCTTTACTTGAGGATGAAAGCGCGCGCCCTGCGTTATCTCTGCTGGCAC
GACATGAAGGTAAAGCCGTCGGACATATTTTATTTACCCGGGCGACCTTCAAAGGAGAAATGGATTCACCTCTGATTCAT
ATCCTTGCTCCCCTGGCGGTCATACCGGAATACCAGGGGATGGGCGTAGGCGGGTTGCTGATACGTACAGGCATAGAACA
CCTGAGGCAGATGGGCTGCCAGACGGTTTTTGTTCTCGGTCACGCCACCTATTACCCCAGACATGGATTTGAACCCTGTG
CCGGAGACAAAGGCTATCCAGCACCTTATCCCATTCCAGAGCAACACAAAGCCTGCTGGATGTTGCAACCACTCACCGCT
CAGCCAATTAACGTTACCGGTCAGATCCAGTGTGCTCAGGCCTTGATGAAACCGGAGCACTGGCGTGAATAA