Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4724687..4725341 Replicon chromosome
Accession NZ_CP036435
Organism Citrobacter sp. ABFQG

Toxin (Protein)


Gene name cptA Uniprot ID A0A0J1NHY7
Locus tag WN16_RS23150 Protein ID WP_003026936.1
Coordinates 4724687..4725094 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A6H3AT26
Locus tag WN16_RS23155 Protein ID WP_003026938.1
Coordinates 4725075..4725341 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
WN16_RS23130 4720635..4722368 - 1734 WP_044700800.1 single-stranded-DNA-specific exonuclease RecJ -
WN16_RS23135 4722374..4723087 - 714 WP_003026923.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
WN16_RS23140 4723111..4724007 - 897 WP_003026928.1 site-specific tyrosine recombinase XerD -
WN16_RS23145 4724121..4724642 + 522 WP_003026933.1 flavodoxin FldB -
WN16_RS23150 4724687..4725094 - 408 WP_003026936.1 protein YgfX Toxin
WN16_RS23155 4725075..4725341 - 267 WP_003026938.1 FAD assembly factor SdhE Antitoxin
WN16_RS23160 4725598..4726578 + 981 WP_003026944.1 tRNA-modifying protein YgfZ -
WN16_RS23165 4726672..4727331 - 660 WP_003838267.1 hemolysin III family protein -
WN16_RS23170 4727494..4727805 - 312 WP_044700802.1 N(4)-acetylcytidine aminohydrolase -
WN16_RS23175 4727858..4728586 + 729 WP_003838265.1 MurR/RpiR family transcriptional regulator -
WN16_RS23180 4728707..4730140 + 1434 WP_044700805.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15953.89 Da        Isoelectric Point: 11.4054

>T119779 WP_003026936.1 NZ_CP036435:c4725094-4724687 [Citrobacter sp. ABFQG]
VVQWQSDLRVSWRAQWLSLLIHGLVAVFILLMPWPLSYTPLWLVLLSLVVFDSVRSQRRINACQGEIRLLMDGRLRWQGQ
EWSIVSAPWMVKTGMMLRLRSDAGKRQHLWLAADSMDDAEWRDLRRLMLQKAKQK

Download         Length: 408 bp

>T119779 NZ_CP036435:c4725094-4724687 [Citrobacter sp. ABFQG]
GTGGTCCAGTGGCAATCTGATTTACGCGTATCATGGCGCGCGCAGTGGCTTTCACTGCTAATTCATGGGCTGGTCGCGGT
GTTTATTTTATTGATGCCCTGGCCATTGAGCTACACCCCATTATGGCTGGTTTTGCTCTCTCTGGTGGTATTCGATAGCG
TTCGCAGTCAGCGTCGAATCAACGCCTGTCAGGGTGAGATTCGGCTGTTGATGGATGGTCGTCTGCGCTGGCAAGGGCAA
GAGTGGTCTATCGTTAGCGCCCCCTGGATGGTTAAAACAGGCATGATGCTGCGTTTGCGCTCTGATGCCGGAAAACGTCA
ACATTTGTGGCTGGCGGCAGACAGTATGGATGATGCTGAGTGGCGGGATTTACGGCGGTTGATGCTGCAAAAGGCGAAGC
AGAAGTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10558.09 Da        Isoelectric Point: 5.1700

>AT119779 WP_003026938.1 NZ_CP036435:c4725341-4725075 [Citrobacter sp. ABFQG]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFIRLLECDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT119779 NZ_CP036435:c4725341-4725075 [Citrobacter sp. ABFQG]
ATGGATATTAACAACAAAGCACGTATTCATTGGGCATGCCGCCGCGGTATGCGCGAGCTGGACATCTCGATCATGCCGTT
TTTCGAACATGAATATGACAGCTTAAGTGACGAAGAAAAACGTATCTTTATCCGTCTGCTAGAATGTGATGATCCAGATT
TATTTAACTGGTTGATGAATCATGGGAAACCAGCTGATGCTGAGCTGGAGCAGATGGTGCGACTTATCCAGACACGGAAT
CGGGAACGTGGTCCAGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0J1NHY7

Antitoxin

Source ID Structure
AlphaFold DB A0A6H3AT26

References