Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1952463..1953083 Replicon chromosome
Accession NZ_CP036435
Organism Citrobacter sp. ABFQG

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag WN16_RS09420 Protein ID WP_002892050.1
Coordinates 1952463..1952681 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID R8WZW8
Locus tag WN16_RS09425 Protein ID WP_003021733.1
Coordinates 1952709..1953083 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
WN16_RS09385 1947696..1948325 + 630 WP_003835929.1 membrane protein -
WN16_RS09390 1948390..1948743 + 354 WP_003831033.1 DUF1428 family protein -
WN16_RS09395 1948795..1950348 - 1554 WP_044699371.1 EAL domain-containing protein -
WN16_RS09400 1950537..1950797 + 261 WP_003021719.1 type B 50S ribosomal protein L31 -
WN16_RS09405 1950799..1950939 + 141 WP_005125190.1 type B 50S ribosomal protein L36 -
WN16_RS09410 1951018..1951488 - 471 WP_003021724.1 YlaC family protein -
WN16_RS09415 1951605..1952156 - 552 WP_044699372.1 maltose O-acetyltransferase -
WN16_RS09420 1952463..1952681 - 219 WP_002892050.1 hemolysin expression modulator Hha Toxin
WN16_RS09425 1952709..1953083 - 375 WP_003021733.1 Hha toxicity modulator TomB Antitoxin
WN16_RS09430 1953571..1956720 - 3150 WP_003021736.1 multidrug efflux RND transporter permease subunit -
WN16_RS09435 1956743..1957936 - 1194 WP_003835922.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T119770 WP_002892050.1 NZ_CP036435:c1952681-1952463 [Citrobacter sp. ABFQG]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T119770 NZ_CP036435:c1952681-1952463 [Citrobacter sp. ABFQG]
ATGTCCGATAAACCATTAACTAAAACAGATTATTTGATGCGCCTGCGACGTTGCCAGACAATTGATACGCTAGAGCGCGT
TATTGAAAAAAATAAATATGAATTGTCCGACAACGAACTGGCTGTATTTTACTCAGCAGCAGATCATCGCCTTGCTGAAT
TGACCATGAATAAGCTTTACGACAAGATTCCAACTTCTGTTTGGAAATTCATTCGCTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14427.23 Da        Isoelectric Point: 5.5653

>AT119770 WP_003021733.1 NZ_CP036435:c1953083-1952709 [Citrobacter sp. ABFQG]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEQSNHGWVNDPTSATSLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT119770 NZ_CP036435:c1953083-1952709 [Citrobacter sp. ABFQG]
ATGGATGAATACTCACCCAAAAGACATGATATCGCGCAGCTTAAATTTCTCTGCGAAACTCTGTATCATGACTGTCTTGC
AAACCTTGAACAAAGTAACCATGGCTGGGTTAATGACCCTACCTCTGCAACCAGCTTGCAGCTCAATGAACTGATAGAGC
ATATTGCAACCTTCGCACTTAATTATAAAATTAAGTACAATGAGGACAATAAGCTGATCGCGCAGATAGATGAATACCTG
GATGACACTTTTATGTTGTTCAGCAGTTATGGTATTAATACGCAGGATCTGCAGAAATGGCGGAAGTCAGGTAATCGACT
GTTTCGCTGTTTTGTCAATGCCACCAGGGCTAATCCTGTTAGTTTGTCTTGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB R8WZW8

References