119769

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yafW-ykfI/CbtA-CbeA
Location 1716771..1717450 Replicon chromosome
Accession NZ_CP036435
Organism Citrobacter sp. ABFQG

Toxin (Protein)


Gene name ykfI Uniprot ID A0A1B7JLK7
Locus tag WN16_RS08270 Protein ID WP_003031349.1
Coordinates 1716771..1717112 (-) Length 114 a.a.

Antitoxin (Protein)


Gene name yafW Uniprot ID A0A1B7JLJ2
Locus tag WN16_RS08275 Protein ID WP_003031347.1
Coordinates 1717133..1717450 (-) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
WN16_RS08245 1712516..1713247 + 732 WP_044702485.1 winged helix-turn-helix domain-containing protein -
WN16_RS08250 1713222..1713695 + 474 WP_044702484.1 hypothetical protein -
WN16_RS08255 1714037..1715485 + 1449 WP_044702495.1 EAL domain-containing protein -
WN16_RS08260 1715677..1716141 + 465 WP_044702482.1 isoprenylcysteine carboxylmethyltransferase family protein -
WN16_RS08270 1716771..1717112 - 342 WP_003031349.1 type IV toxin-antitoxin system toxin YkfI Toxin
WN16_RS08275 1717133..1717450 - 318 WP_003031347.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
WN16_RS08280 1717468..1717689 - 222 WP_003031346.1 DUF987 domain-containing protein -
WN16_RS08285 1717698..1718174 - 477 WP_003031345.1 RadC family protein -
WN16_RS08290 1718190..1718651 - 462 WP_003031344.1 antirestriction protein -
WN16_RS08295 1718665..1718856 - 192 Protein_1568 DUF905 family protein -
WN16_RS08300 1719360..1721357 + 1998 WP_016245729.1 choline BCCT transporter BetT -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1712516..1732393 19877


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(5-104)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12921.01 Da        Isoelectric Point: 9.6543

>T119769 WP_003031349.1 NZ_CP036435:c1717112-1716771 [Citrobacter sp. ABFQG]
MKTLPATTQRAVKPCLSPVAVWQMLLTRLLEQHYGLTINDTPFCNEAVIKEHIDAGITLADAVNFLVEKYELVRIDRKGF
SWQEQSPYLRAVDILRARQATGLLRQSRNNVVR

Download         Length: 342 bp

>T119769 NZ_CP036435:c1717112-1716771 [Citrobacter sp. ABFQG]
ATGAAAACTTTACCTGCAACAACTCAGCGGGCGGTGAAGCCCTGCCTGTCACCCGTGGCTGTCTGGCAAATGTTACTGAC
ACGTCTGCTGGAACAGCACTATGGTCTGACAATAAACGACACGCCATTCTGCAATGAGGCTGTGATTAAGGAACACATCG
ATGCCGGTATCACCCTAGCCGATGCCGTGAATTTTCTGGTAGAAAAATACGAGCTGGTTCGTATAGACAGGAAGGGATTT
AGCTGGCAGGAACAATCTCCTTATCTCCGGGCTGTAGACATTCTGCGAGCGCGGCAGGCAACTGGCTTGTTGCGGCAAAG
CCGTAACAACGTAGTACGATGA

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 12094.74 Da        Isoelectric Point: 7.0370

>AT119769 WP_003031347.1 NZ_CP036435:c1717450-1717133 [Citrobacter sp. ABFQG]
MSKITWGLQRDITPRLGARLVQEGNRLHYLADRASMTGKFSDIEYRKLDETFPHFIRQMESMLTTGELSTHHAHCVTLYH
NDLTCEADTLGSCGYVYIAIYPTQR

Download         Length: 318 bp

>AT119769 NZ_CP036435:c1717450-1717133 [Citrobacter sp. ABFQG]
ATGAGCAAAATCACATGGGGTCTGCAGCGTGATATCACGCCACGTCTGGGAGCCCGTCTGGTGCAGGAAGGCAACCGACT
GCATTATCTGGCTGACCGGGCCAGCATGACCGGCAAGTTCAGTGACATCGAATACCGGAAGCTGGATGAAACATTCCCGC
ACTTTATCCGCCAGATGGAATCGATGCTGACCACTGGTGAACTCAGCACCCACCATGCCCACTGCGTTACCCTGTACCAC
AACGATTTAACCTGCGAAGCCGACACCCTTGGCAGTTGCGGCTACGTATACATCGCCATTTACCCCACTCAGCGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1B7JLK7

Antitoxin

Source ID Structure
AlphaFold DB A0A1B7JLJ2

References