Detailed information of TA system TA119768

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): ypjF-yafW/CbtA-CbeA
• Location: 1334760..1335439
• Replicon: chromosome
• Accession: NZ_CP036435
• Organism: Citrobacter sp. ABFQG

Toxin (Protein)

• Gene name: ypjF
• Uniprot ID: -
• Locus tag: WN16_RS06530
• Protein ID: WP_063844629.1
• Coordinates: 1335098..1335439 (+)
• Length: 114 a.a.

Antitoxin (Protein)

• Gene name: yafW
• Uniprot ID: -
• Locus tag: WN16_RS06525
• Protein ID: WP_063844628.1
• Coordinates: 1334760..1335077 (+)
• Length: 106 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
WN16_RS06480	1330194..1331015	+	822	WP_063844621.1	DUF945 domain-containing protein	-
WN16_RS06485	1331232..1331933	+	702	WP_063844622.1	WYL domain-containing protein	-
WN16_RS06490	1331974..1332219	+	246	WP_032294624.1	hypothetical protein	-
WN16_RS06495	1332209..1332652	+	444	WP_088169063.1	hypothetical protein	-
WN16_RS06500	1332676..1333143	+	468	WP_063844624.1	hypothetical protein	-
WN16_RS06505	1333220..1333459	+	240	WP_063844625.1	DUF905 domain-containing protein	-
WN16_RS06510	1333561..1334019	+	459	WP_063844626.1	antirestriction protein	-
WN16_RS06515	1334035..1334511	+	477	WP_063844627.1	RadC family protein	-
WN16_RS06520	1334520..1334741	+	222	WP_007893437.1	DUF987 domain-containing protein	-
WN16_RS06525	1334760..1335077	+	318	WP_063844628.1	type IV toxin-antitoxin system antitoxin YafW	Antitoxin
WN16_RS06530	1335098..1335439	+	342	WP_063844629.1	TA system toxin CbtA family protein	Toxin
WN16_RS06535	1335698..1336705	+	1008	WP_063844630.1	restriction endonuclease	-
WN16_RS06540	1336886..1337758	-	873	WP_080942000.1	HNH endonuclease	-
WN16_RS06545	1337899..1338534	+	636	WP_044699099.1	HNH endonuclease	-
WN16_RS06550	1338588..1338950	-	363	WP_044699097.1	endoribonuclease SymE	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	1315547..1335439	19892

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-109)

Antitoxin

• Antitoxin CbeA (6-103)

Sequences

Toxin

Protein

• Length: 114 a.a.
• Molecular weight: 12761.71 Da
• Isoelectric Point: 8.0324

>T119768 WP_063844629.1 NZ_CP036435:1335098-1335439 [Citrobacter sp. ABFQG]
MKTLPATNPQVATLCLSPVAVWQMLLARLLEQHYGLTLNDTPFSDETVIQEHIDAGISLADAVNFLVEKYGLVRIDRRGF
DWQEQSPYLRAVDILRARQATGLLKRNRISAAR

Nucleotide

• Length: 342 bp

>T119768 NZ_CP036435:1335098-1335439 [Citrobacter sp. ABFQG]
ATGAAAACTCTACCTGCAACAAATCCGCAGGTGGCGACGCTATGTCTGTCGCCCGTGGCGGTCTGGCAAATGCTGCTTGC
ACGCCTGCTGGAACAACATTATGGCCTGACACTCAACGACACACCATTCAGTGATGAAACGGTAATTCAGGAACATATCG
ATGCCGGTATATCTTTGGCCGATGCCGTTAATTTTCTGGTGGAAAAGTATGGGCTGGTTCGTATTGATCGTAGGGGATTC
GACTGGCAAGAACAGTCCCCATATCTGCGGGCAGTCGATATTCTGCGGGCGCGACAGGCAACTGGTTTATTGAAAAGAAA
TCGCATTAGCGCGGCACGGTGA

Antitoxin

Protein

• Length: 106 a.a.
• Molecular weight: 11987.59 Da
• Isoelectric Point: 7.0268

>AT119768 WP_063844628.1 NZ_CP036435:1334760-1335077 [Citrobacter sp. ABFQG]
MSNPTRGLQREITPRLGARLVQEGNRLHYLADRASITGKFSDIECRKLDETFPHFIRQMESMLTTGELSPHHAYCVTLYH
NDLTCEADTLGSCGYVYIAVYPTHR

Nucleotide

• Length: 318 bp

>AT119768 NZ_CP036435:1334760-1335077 [Citrobacter sp. ABFQG]
ATGAGCAACCCTACCAGGGGCCTGCAGCGGGAGATTACACCGCGCCTGGGAGCCCGTCTGGTGCAGGAAGGCAACCGACT
GCATTATCTGGCTGACCGGGCCAGCATCACCGGCAAGTTCAGTGACATCGAATGCCGGAAGCTGGATGAAACATTCCCGC
ACTTTATCCGCCAGATGGAATCGATGCTGACCACCGGCGAACTCAGCCCCCACCATGCCTACTGCGTTACCCTGTACCAC
AACGATTTAACCTGCGAAGCCGACACCCTTGGCAGTTGCGGCTACGTATACATCGCCGTTTACCCCACTCATCGTTAA