Detailed information of TA system TA119767

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RelB
• Location: 1268211..1268727
• Replicon: chromosome
• Accession: NZ_CP036435
• Organism: Citrobacter sp. ABFQG

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: WN16_RS06210
• Protein ID: WP_044699148.1
• Coordinates: 1268443..1268727 (+)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A0J1MV10
• Locus tag: WN16_RS06205
• Protein ID: WP_003839576.1
• Coordinates: 1268211..1268453 (+)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
WN16_RS06185	1263226..1264359	+	1134	WP_016149471.1	amidohydrolase/deacetylase family metallohydrolase	-
WN16_RS06190	1264343..1265461	+	1119	WP_044699152.1	DgaE family pyridoxal phosphate-dependent ammonia lyase	-
WN16_RS06195	1265458..1266198	+	741	WP_044699149.1	KDGP aldolase family protein	-
WN16_RS06200	1266220..1268133	+	1914	WP_003839574.1	BglG family transcription antiterminator	-
WN16_RS06205	1268211..1268453	+	243	WP_003839576.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
WN16_RS06210	1268443..1268727	+	285	WP_044699148.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
WN16_RS06215	1268731..1269195	-	465	WP_032937736.1	anaerobic ribonucleoside-triphosphate reductase-activating protein	-
WN16_RS06220	1269302..1271440	-	2139	WP_003025782.1	anaerobic ribonucleoside-triphosphate reductase	-
WN16_RS06225	1271818..1272402	-	585	WP_003839584.1	fructose PTS transporter subunit IIA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-82)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-69)

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 10865.69 Da
• Isoelectric Point: 10.1988

>T119767 WP_044699148.1 NZ_CP036435:1268443-1268727 [Citrobacter sp. ABFQG]
MTYELEFDPRALKEWHKLGDTVKAQFKKKLADVLLNPRIDSARLNGLPDCYKIKLKSSGYRLVYQVRDEVVTVFVVAVGK
RQHSAVYLDANKRL

Nucleotide

• Length: 285 bp

>T119767 NZ_CP036435:1268443-1268727 [Citrobacter sp. ABFQG]
ATGACTTATGAACTGGAATTCGACCCGAGAGCCTTAAAAGAGTGGCATAAACTGGGTGATACGGTGAAGGCTCAGTTTAA
GAAGAAGTTGGCCGACGTGTTGTTGAACCCCAGAATTGACTCTGCCCGTTTAAACGGTCTTCCAGATTGCTATAAAATTA
AGCTTAAATCGTCCGGCTATCGTCTGGTGTACCAGGTTCGGGATGAGGTTGTGACCGTGTTTGTTGTCGCGGTCGGCAAG
CGACAACATTCGGCCGTTTATCTCGATGCAAACAAACGGCTTTAG

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 8961.34 Da
• Isoelectric Point: 5.0651

>AT119767 WP_003839576.1 NZ_CP036435:1268211-1268453 [Citrobacter sp. ABFQG]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTVSDSEDTLIQTVRERLASPQKGIKVSLDDL

Nucleotide

• Length: 243 bp

>AT119767 NZ_CP036435:1268211-1268453 [Citrobacter sp. ABFQG]
ATGGCCACGCTGAACGTCCGTCTGGATGACAAACTCAAAAATGAGGCTTATGCCGTGCTGGAAAAACTGAACATTACTCC
AACGGAAGCTGTGCGATTACTGTTTCAGTACGTCGCGGAAACGGGGCGCATGCCAGTGAAAACCGTCACCGTTAGCGACA
GCGAAGATACACTGATTCAGACAGTCCGGGAGAGGCTGGCCAGCCCGCAAAAAGGAATCAAGGTTAGTCTGGATGACTTA
TGA

Structures

Antitoxin

• AlphaFold DB: A0A0J1MV10