Detailed information of TA system TA119761

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/Phd(antitoxin)
• Location: 2619641..2620212
• Replicon: chromosome
• Accession: NZ_CP036423
• Organism: Aequoribacter fuscus strain IMCC3088

Toxin (Protein)

• Gene name: relE
• Uniprot ID: F3L633
• Locus tag: EYZ66_RS11870
• Protein ID: WP_009577343.1
• Coordinates: 2619919..2620212 (+)
• Length: 98 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: F3L632
• Locus tag: EYZ66_RS11865
• Protein ID: WP_009577342.1
• Coordinates: 2619641..2619922 (+)
• Length: 94 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EYZ66_RS11845 (EYZ66_11850)	2614839..2616740	+	1902	WP_040816167.1	ATP-binding cassette domain-containing protein	-
EYZ66_RS11850 (EYZ66_11855)	2616737..2617018	-	282	WP_009575055.1	GIY-YIG nuclease family protein	-
EYZ66_RS11855 (EYZ66_11860)	2617249..2617575	+	327	WP_009575053.1	thioredoxin TrxA	-
EYZ66_RS11860 (EYZ66_11865)	2617752..2619020	+	1269	WP_009575051.1	transcription termination factor Rho	-
EYZ66_RS11865 (EYZ66_11870)	2619641..2619922	+	282	WP_009577342.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
EYZ66_RS11870 (EYZ66_11875)	2619919..2620212	+	294	WP_009577343.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
EYZ66_RS11875 (EYZ66_11880)	2620548..2622032	+	1485	WP_009577229.1	4-hydroxy-3-polyprenylbenzoate decarboxylase	-
EYZ66_RS11880 (EYZ66_11885)	2622069..2623229	-	1161	WP_009577228.1	heme biosynthesis HemY N-terminal domain-containing protein	-
EYZ66_RS11885 (EYZ66_11890)	2623226..2624569	-	1344	WP_009577227.1	uroporphyrinogen-III C-methyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-89)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (9-74)

Sequences

Toxin

Protein

• Length: 98 a.a.
• Molecular weight: 11018.74 Da
• Isoelectric Point: 6.9757

>T119761 WP_009577343.1 NZ_CP036423:2619919-2620212 [Aequoribacter fuscus]
VKIQWSPVALDRASECAAYIAVDKPAAAKDWIYELFDSVGLLASTPYMGRVVPELNNARYREILFGNYRVIYSIKAEHIE
ILTIRGVRQILASEKFD

Nucleotide

• Length: 294 bp

>T119761 NZ_CP036423:2619919-2620212 [Aequoribacter fuscus]
GTGAAAATCCAGTGGTCGCCAGTTGCCCTTGATAGAGCAAGCGAATGCGCTGCCTATATTGCGGTAGACAAGCCAGCGGC
CGCAAAAGACTGGATATATGAACTTTTTGACAGCGTAGGCTTACTGGCATCAACACCCTATATGGGACGCGTTGTACCGG
AACTCAACAATGCGCGCTATCGCGAAATTCTGTTCGGCAACTACCGCGTAATCTACAGCATCAAAGCCGAACACATCGAA
ATTCTGACCATCCGAGGCGTCAGGCAGATTTTGGCTTCAGAAAAGTTTGATTAG

Antitoxin

Protein

• Length: 94 a.a.
• Molecular weight: 10516.03 Da
• Isoelectric Point: 5.8899

>AT119761 WP_009577342.1 NZ_CP036423:2619641-2619922 [Aequoribacter fuscus]
MRRINLEQDIKPLSEFRAGTSNFIRQVNETHRPLLITQRGKGVAVLLDVSEYESMREKLEILEDIYLAESQLGAGGGIDS
ETAKSKLLERLKT

Nucleotide

• Length: 282 bp

>AT119761 NZ_CP036423:2619641-2619922 [Aequoribacter fuscus]
ATGCGACGCATCAATCTAGAGCAAGACATTAAGCCACTGTCGGAATTTCGAGCGGGAACATCAAACTTCATTCGCCAAGT
GAATGAAACGCATCGCCCCTTGCTCATCACTCAGCGCGGCAAAGGTGTCGCGGTATTACTCGACGTCTCTGAATACGAGT
CAATGCGTGAGAAACTCGAAATTTTAGAAGACATCTATCTCGCGGAAAGCCAATTGGGCGCAGGTGGGGGCATCGATTCC
GAGACCGCAAAATCAAAACTATTGGAGCGTCTCAAAACGTGA

Structures

Toxin

• AlphaFold DB: F3L633

Antitoxin

• AlphaFold DB: F3L632