Detailed information of TA system TA119760

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): phd-doc/Doc(toxin)
• Location: 2566595..2567160
• Replicon: chromosome
• Accession: NZ_CP036423
• Organism: Aequoribacter fuscus strain IMCC3088

Toxin (Protein)

• Gene name: doc
• Uniprot ID: F3L3R9
• Locus tag: EYZ66_RS11600
• Protein ID: WP_009576449.1
• Coordinates: 2566595..2566990 (-)
• Length: 132 a.a.

Antitoxin (Protein)

• Gene name: phd
• Uniprot ID: F3L3S0
• Locus tag: EYZ66_RS11605
• Protein ID: WP_009576450.1
• Coordinates: 2566990..2567160 (-)
• Length: 57 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EYZ66_RS11575 (EYZ66_11580)	2562028..2563107	-	1080	WP_009576444.1	DegT/DnrJ/EryC1/StrS family aminotransferase	-
EYZ66_RS11580 (EYZ66_11585)	2563128..2563703	-	576	WP_040816927.1	acyltransferase	-
EYZ66_RS11585 (EYZ66_11590)	2563690..2564646	-	957	WP_009576446.1	Gfo/Idh/MocA family oxidoreductase	-
EYZ66_RS11590 (EYZ66_11595)	2564659..2565933	-	1275	WP_009576447.1	Vi polysaccharide biosynthesis UDP-N-acetylglucosamine C-6 dehydrogenase TviB	-
EYZ66_RS11595 (EYZ66_11600)	2565973..2566305	-	333	WP_009576448.1	MarR family EPS-associated transcriptional regulator	-
EYZ66_RS11600 (EYZ66_11605)	2566595..2566990	-	396	WP_009576449.1	type II toxin-antitoxin system death-on-curing family toxin	Toxin
EYZ66_RS11605 (EYZ66_11610)	2566990..2567160	-	171	WP_009576450.1	hypothetical protein	Antitoxin
EYZ66_RS14300 (EYZ66_11615)	2567441..2567539	-	99	Protein_2278	type II toxin-antitoxin system prevent-host-death family antitoxin	-
EYZ66_RS11615 (EYZ66_11620)	2567577..2567906	-	330	WP_040816929.1	MarR family EPS-associated transcriptional regulator	-
EYZ66_RS11620 (EYZ66_11625)	2568199..2568675	-	477	WP_040816930.1	hypothetical protein	-
EYZ66_RS11625 (EYZ66_11630)	2568764..2569732	-	969	WP_009576454.1	Wzz/FepE/Etk N-terminal domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Death on curing protein (1-127)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 132 a.a.
• Molecular weight: 14407.26 Da
• Isoelectric Point: 3.9655

>T119760 WP_009576449.1 NZ_CP036423:c2566990-2566595 [Aequoribacter fuscus]
MQLIRFPLERVVDINEQILKTEAGFKGAPDLGKLQGALSRIDNAIWYEGLEDVFEIAAKYASSIAVAHALSDANKRTALA
VALEFLSLSDFDLSDDNDLLADAVRDLVLEVLTETDFADILYAQYAKDLGE

Nucleotide

• Length: 396 bp

>T119760 NZ_CP036423:c2566990-2566595 [Aequoribacter fuscus]
ATGCAGCTGATTCGGTTTCCGCTCGAGCGTGTCGTCGACATCAATGAGCAGATACTAAAAACCGAAGCTGGGTTCAAAGG
GGCTCCTGATTTGGGTAAGTTGCAGGGTGCGCTCTCTCGGATTGATAACGCGATATGGTATGAAGGTCTGGAGGATGTTT
TTGAGATTGCGGCTAAATACGCGTCAAGTATTGCTGTAGCACATGCATTGTCAGACGCCAACAAACGCACAGCCCTTGCC
GTCGCTTTAGAGTTTCTTTCCCTCAGTGATTTTGATTTATCCGATGACAATGATCTGTTAGCTGACGCAGTGAGAGATCT
TGTGCTTGAAGTTCTGACTGAGACAGATTTTGCGGACATCCTTTACGCTCAATATGCCAAGGATCTCGGCGAGTAG

Antitoxin

Protein

• Length: 57 a.a.
• Molecular weight: 6305.64 Da
• Isoelectric Point: 10.9812

>AT119760 WP_009576450.1 NZ_CP036423:c2567160-2566990 [Aequoribacter fuscus]
MNKIVEKYGLKPVARPKVKLVRELDLSGPAGKEIVRSKTKLVMQVHKNTFAKLADM

Nucleotide

• Length: 171 bp

>AT119760 NZ_CP036423:c2567160-2566990 [Aequoribacter fuscus]
ATGAACAAAATCGTCGAGAAATATGGTTTGAAGCCCGTTGCAAGACCCAAGGTAAAGCTTGTGCGGGAGCTCGATTTGTC
GGGCCCAGCGGGCAAAGAGATTGTTCGCTCTAAAACCAAGCTCGTCATGCAGGTTCACAAGAATACATTCGCGAAATTGG
CTGACATGTAA

Structures

Toxin

• AlphaFold DB: F3L3R9

Antitoxin

• AlphaFold DB: F3L3S0