Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 2250773..2251398 Replicon chromosome
Accession NZ_CP036423
Organism Aequoribacter fuscus strain IMCC3088

Toxin (Protein)


Gene name vapC Uniprot ID A0A7Z2NUI1
Locus tag EYZ66_RS10055 Protein ID WP_040818244.1
Coordinates 2251009..2251398 (+) Length 130 a.a.

Antitoxin (Protein)


Gene name VapB1 Uniprot ID F3L6A4
Locus tag EYZ66_RS10050 Protein ID WP_009577423.1
Coordinates 2250773..2251000 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EYZ66_RS10030 (EYZ66_10030) 2246568..2247338 + 771 WP_009577062.1 class II aldolase/adducin family protein -
EYZ66_RS10035 (EYZ66_10035) 2247347..2248264 + 918 WP_009577061.1 TauD/TfdA family dioxygenase -
EYZ66_RS10040 (EYZ66_10040) 2248443..2249249 + 807 WP_009577060.1 SDR family oxidoreductase -
EYZ66_RS10045 (EYZ66_10045) 2249284..2250552 - 1269 WP_160195664.1 alkyl sulfatase dimerization domain-containing protein -
EYZ66_RS10050 (EYZ66_10050) 2250773..2251000 + 228 WP_009577423.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
EYZ66_RS10055 (EYZ66_10055) 2251009..2251398 + 390 WP_040818244.1 type II toxin-antitoxin system VapC family toxin Toxin
EYZ66_RS10060 (EYZ66_10060) 2251601..2251921 - 321 WP_009577393.1 helix-turn-helix domain-containing protein -
EYZ66_RS10065 (EYZ66_10065) 2251911..2252210 - 300 WP_216089007.1 BrnT family toxin -
EYZ66_RS10075 (EYZ66_10075) 2253861..2254223 - 363 WP_009575884.1 MerR family transcriptional regulator -
EYZ66_RS10080 (EYZ66_10080) 2254207..2254506 - 300 WP_009575885.1 integration host factor subunit alpha -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-121)

Antitoxin

SpoVT-AbrB domain

(6-42)


Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 14416.56 Da        Isoelectric Point: 8.8560

>T119758 WP_040818244.1 NZ_CP036423:2251009-2251398 [Aequoribacter fuscus]
MLDTNICIYLIKQQPESVRKKFESLAIGSVSMSLITYGELKYGAFRSNSSSKAIAVLDRLTSYIPVLSMHQDVALEYAEI
RADLASKGTPIGNNDLWIAAHARSSRHTLVTNNLKEFKRVTGLEVENWV

Download         Length: 390 bp

>T119758 NZ_CP036423:2251009-2251398 [Aequoribacter fuscus]
ATGCTAGATACAAACATCTGCATTTACCTAATAAAACAACAGCCTGAAAGCGTACGAAAGAAATTTGAGTCTCTCGCCAT
CGGCTCTGTCAGTATGTCGCTCATCACATATGGCGAACTGAAATATGGAGCATTTCGGAGCAATAGTTCTTCAAAAGCGA
TTGCCGTGCTAGATCGATTGACAAGCTACATTCCGGTGCTATCAATGCATCAAGATGTGGCACTAGAATACGCAGAGATT
AGAGCAGACTTAGCGAGTAAAGGAACGCCGATAGGCAATAACGACCTATGGATCGCCGCCCACGCGCGCAGTTCACGTCA
CACACTGGTTACTAACAATCTAAAAGAGTTCAAGCGCGTAACGGGGCTTGAGGTCGAAAACTGGGTTTGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8719.91 Da        Isoelectric Point: 4.6583

>AT119758 WP_009577423.1 NZ_CP036423:2250773-2251000 [Aequoribacter fuscus]
MDAKIFKSGNSQAVRIPKEFRFDVNEVEIFKRGEELILRPKAKNLSVAFDLFSEMPDDFMVDGRQDDKPQEREGL

Download         Length: 228 bp

>AT119758 NZ_CP036423:2250773-2251000 [Aequoribacter fuscus]
ATGGACGCAAAGATCTTTAAATCTGGCAACAGCCAAGCTGTCCGAATCCCCAAGGAATTTCGCTTCGATGTAAATGAGGT
CGAGATATTCAAACGAGGTGAAGAATTGATTTTAAGGCCCAAAGCAAAAAACCTCAGTGTCGCGTTTGATCTCTTCAGCG
AAATGCCTGACGATTTTATGGTCGACGGACGACAGGACGATAAGCCCCAAGAACGTGAGGGGCTCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7Z2NUI1

Antitoxin

Source ID Structure
AlphaFold DB F3L6A4

References