Detailed information of TA system TA119756

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 1054780..1055414
• Replicon: chromosome
• Accession: NZ_CP036420
• Organism: Cereibacter sphaeroides strain HJ

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: EYE35_RS20885
• Protein ID: WP_202879123.1
• Coordinates: 1054780..1054968 (+)
• Length: 63 a.a.

Antitoxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: EYE35_RS20890
• Protein ID: WP_115474995.1
• Coordinates: 1055019..1055414 (+)
• Length: 132 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EYE35_RS22255	1049920..1050087	+	168	WP_191993909.1	hypothetical protein	-
EYE35_RS20860	1050084..1050299	+	216	WP_137459189.1	hypothetical protein	-
EYE35_RS20865	1050391..1050708	+	318	WP_137459190.1	hypothetical protein	-
EYE35_RS20870	1050826..1051698	+	873	WP_137459191.1	hypothetical protein	-
EYE35_RS20875	1051984..1052808	+	825	Protein_905	chromosome partitioning protein ParB	-
EYE35_RS20880	1052962..1054581	+	1620	WP_137459192.1	recombinase family protein	-
EYE35_RS20885	1054780..1054968	+	189	WP_202879123.1	type II toxin-antitoxin system HicA family toxin	Toxin
EYE35_RS20890	1055019..1055414	+	396	WP_115474995.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
EYE35_RS22260	1055628..1055810	-	183	WP_191993944.1	hypothetical protein	-
EYE35_RS20895	1056485..1057084	-	600	WP_137459193.1	cytochrome b/b6 domain-containing protein	-
EYE35_RS20900	1057091..1057405	-	315	WP_112331019.1	PepSY domain-containing protein	-
EYE35_RS20905	1057541..1058200	+	660	WP_137459194.1	response regulator transcription factor	-
EYE35_RS20910	1058197..1059519	+	1323	WP_137459195.1	sensor histidine kinase N-terminal domain-containing protein	-
EYE35_RS20915	1059532..1059777	-	246	WP_137459196.1	VIT1/CCC1 transporter family protein	-
EYE35_RS20920	1059870..1060361	-	492	WP_115474999.1	diheme cytochrome c	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (8-61)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (4-124)

Sequences

Toxin

Protein

• Length: 63 a.a.
• Molecular weight: 6894.13 Da
• Isoelectric Point: 11.1468

>T119756 WP_202879123.1 NZ_CP036420:1054780-1054968 [Cereibacter sphaeroides]
VKIETDSRTILTILKAAGFEEVSKRGSHLKLRKEGRTVIVPHPKKDLPLGTARSIYRQAGLI

Nucleotide

• Length: 189 bp

>T119756 NZ_CP036420:1054780-1054968 [Cereibacter sphaeroides]
GTGAAGATAGAAACAGACAGCCGGACGATCCTGACGATCTTGAAAGCAGCCGGTTTTGAGGAGGTTTCGAAGAGAGGGTC
ACACCTCAAATTGCGGAAAGAGGGCAGGACGGTGATCGTGCCACACCCGAAGAAGGACCTTCCGCTAGGAACCGCTCGAA
GCATCTATCGGCAAGCCGGGCTCATCTGA

Antitoxin

Protein

• Length: 132 a.a.
• Molecular weight: 14177.01 Da
• Isoelectric Point: 4.4840

>AT119756 WP_115474995.1 NZ_CP036420:1055019-1055414 [Cereibacter sphaeroides]
MHYFTAIVHKDPNSAYGLTFPDLPGCFAAADDWSEIPAKAAEALDLWFEDEPAVEPASIDAIQSREDVRRALAEGASLMT
FAYVPADGKLERVNVSMDRGLLRAIDATASARGMTRSAFLAAVARREIAGF

Nucleotide

• Length: 396 bp

>AT119756 NZ_CP036420:1055019-1055414 [Cereibacter sphaeroides]
ATGCACTACTTCACCGCAATCGTTCACAAAGACCCGAATTCAGCCTATGGCCTCACCTTCCCGGATCTTCCCGGTTGCTT
TGCTGCCGCTGACGACTGGTCGGAGATCCCCGCTAAAGCGGCGGAGGCGCTCGACCTCTGGTTCGAGGATGAGCCGGCCG
TCGAGCCCGCCTCCATCGACGCGATCCAGTCTCGTGAGGACGTTCGGAGGGCGCTGGCCGAGGGCGCTTCTCTGATGACC
TTCGCCTATGTGCCCGCGGACGGGAAGCTCGAGCGGGTCAACGTCTCCATGGACCGGGGCCTTCTGCGTGCCATCGATGC
CACGGCGTCGGCCCGGGGGATGACCAGGTCGGCCTTCCTCGCCGCGGTTGCTCGGCGCGAGATCGCCGGCTTCTGA