Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1183107..1183737 Replicon chromosome
Accession NZ_CP036419
Organism Cereibacter sphaeroides strain HJ

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag EYE35_RS06020 Protein ID WP_202879110.1
Coordinates 1183549..1183737 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name hicA Uniprot ID -
Locus tag EYE35_RS06015 Protein ID WP_101327249.1
Coordinates 1183107..1183502 (-) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EYE35_RS05985 1178879..1179349 - 471 WP_137457556.1 Hint domain-containing protein -
EYE35_RS05995 1179657..1180991 + 1335 WP_137457557.1 trigger factor -
EYE35_RS06000 1181355..1181924 - 570 WP_137457558.1 50S ribosomal protein L9 -
EYE35_RS06005 1181937..1182188 - 252 WP_196772431.1 30S ribosomal protein S18 -
EYE35_RS06010 1182185..1182592 - 408 WP_002720282.1 30S ribosomal protein S6 -
EYE35_RS22180 1182872..1183027 + 156 WP_202879111.1 late control protein -
EYE35_RS06015 1183107..1183502 - 396 WP_101327249.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
EYE35_RS06020 1183549..1183737 - 189 WP_202879110.1 type II toxin-antitoxin system HicA family toxin Toxin
EYE35_RS22290 1184861..1185217 + 357 WP_202879112.1 hypothetical protein -
EYE35_RS06035 1185485..1186975 - 1491 WP_137457560.1 Na+/H+ antiporter NhaC -
EYE35_RS06040 1187567..1188343 - 777 WP_137457561.1 MetQ/NlpA family ABC transporter substrate-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(8-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(4-124)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 6814.06 Da        Isoelectric Point: 10.8173

>T119755 WP_202879110.1 NZ_CP036419:c1183737-1183549 [Cereibacter sphaeroides]
VKIETDSRKIIMVLKAAGFEEVSKGGSHLKLRKGGRTVIVPHPKKDLPFGTARNIYEQAALI

Download         Length: 189 bp

>T119755 NZ_CP036419:c1183737-1183549 [Cereibacter sphaeroides]
GTGAAGATCGAAACGGACAGCCGGAAGATCATCATGGTCTTGAAGGCAGCGGGTTTCGAAGAGGTCTCGAAGGGGGGATC
ACACCTCAAGCTCCGGAAAGGCGGCAGGACCGTGATCGTGCCGCACCCAAAGAAGGATCTGCCCTTCGGAACGGCCCGCA
ACATCTACGAACAGGCCGCGCTCATCTGA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14128.01 Da        Isoelectric Point: 4.5849

>AT119755 WP_101327249.1 NZ_CP036419:c1183502-1183107 [Cereibacter sphaeroides]
MHYYTVVVHKEVGSAYGLTFPDIPGCFAAADDWSEISAKATEALDLWFEDAEEVAASPVDVIRARKDVQEALTSGASLMT
LSYIPADGKLERVNISMDRGLLRAIDATASARGMTRSAFLAAVARREIAGF

Download         Length: 396 bp

>AT119755 NZ_CP036419:c1183502-1183107 [Cereibacter sphaeroides]
ATGCACTACTACACCGTTGTCGTGCACAAGGAGGTCGGGTCAGCCTACGGCCTCACCTTCCCTGATATTCCTGGCTGCTT
CGCGGCGGCCGACGACTGGTCGGAGATCTCCGCCAAGGCGACGGAGGCTCTCGATCTCTGGTTCGAGGACGCGGAGGAGG
TTGCTGCTTCGCCGGTTGACGTGATCCGGGCCCGGAAAGACGTGCAGGAGGCTCTCACCAGCGGGGCCAGCCTCATGACG
TTGTCGTATATTCCTGCGGACGGAAAGCTCGAACGCGTGAACATCTCGATGGATCGGGGTTTGCTCCGCGCTATCGACGC
GACCGCGTCCGCTCGGGGCATGACCCGGTCGGCCTTCCTCGCGGCGGTGGCTCGCCGCGAGATCGCCGGCTTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References