Detailed information of TA system TA119754

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RelB
• Location: 6080..6630
• Replicon: plasmid p41060
• Accession: NZ_CP036409
• Organism: Komagataeibacter saccharivorans strain JH1

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A0D6N6H9
• Locus tag: KSAC_RS16820
• Protein ID: WP_048839683.1
• Coordinates: 6337..6630 (+)
• Length: 98 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: KSAC_RS16815
• Protein ID: WP_015074683.1
• Coordinates: 6080..6340 (+)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KSAC_RS16795	1384..2058	+	675	WP_132307007.1	ParA family protein	-
KSAC_RS16800	2561..2815	+	255	WP_132307009.1	hypothetical protein	-
KSAC_RS16805	2975..3889	-	915	WP_132307011.1	plasmid replication initiator	-
KSAC_RS16810	4898..5932	+	1035	WP_132307013.1	tyrosine-type recombinase/integrase	-
KSAC_RS16815	6080..6340	+	261	WP_015074683.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
KSAC_RS16820	6337..6630	+	294	WP_048839683.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	Toxin
KSAC_RS16825	6822..8051	+	1230	WP_132307015.1	hypothetical protein	-
KSAC_RS16830	8389..8889	-	501	WP_132307017.1	hypothetical protein	-
KSAC_RS16835	9103..9429	+	327	WP_132307019.1	hypothetical protein	-
KSAC_RS16840	9883..10515	+	633	WP_132307067.1	MucR family transcriptional regulator	-
KSAC_RS16845	10588..11388	+	801	WP_132307021.1	damage-inducible mutagenesis protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..41060	41060

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-86)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-72)

Sequences

Toxin

Protein

• Length: 98 a.a.
• Molecular weight: 11605.30 Da
• Isoelectric Point: 7.1645

>T119754 WP_048839683.1 NZ_CP036409:6337-6630 [Komagataeibacter saccharivorans]
MKEYCLEFDDRALREWDALDGSVRKKFEKKLEKLIWNPHSPGNELHRDLSGFYKIKLLKDGYRLVYQVIDERIVIYVIAV
GRRADNEIYELASQRTE

Nucleotide

• Length: 294 bp

>T119754 NZ_CP036409:6337-6630 [Komagataeibacter saccharivorans]
ATGAAAGAGTATTGTCTTGAGTTCGACGATAGAGCGCTCAGGGAGTGGGATGCTCTTGACGGCAGCGTGCGTAAGAAATT
TGAAAAGAAGCTGGAAAAACTAATCTGGAACCCTCACTCTCCAGGAAACGAGCTTCATCGCGACCTATCAGGGTTTTACA
AGATCAAGCTTTTGAAAGATGGCTACCGTCTTGTTTATCAGGTCATCGACGAACGGATCGTCATCTATGTGATTGCCGTT
GGTCGGCGAGCTGATAATGAGATTTATGAATTAGCGTCGCAGCGGACAGAGTGA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9710.11 Da
• Isoelectric Point: 9.8607

>AT119754 WP_015074683.1 NZ_CP036409:6080-6340 [Komagataeibacter saccharivorans]
MSAVTFRVDETLKAAAVEKLSAQGISLSDALRDTLAYIAETGRSPVKRTLVTDEDAQLIEIVRERLKNPTQKHRMTFAEL
KSRHRE

Nucleotide

• Length: 261 bp

>AT119754 NZ_CP036409:6080-6340 [Komagataeibacter saccharivorans]
ATGTCTGCTGTTACATTCCGGGTAGATGAAACGCTTAAGGCAGCCGCAGTTGAGAAGTTGTCGGCTCAAGGCATTTCACT
TTCTGACGCATTGCGCGATACCCTCGCATATATTGCTGAAACGGGGCGCTCTCCGGTCAAGCGTACACTTGTCACAGACG
AGGATGCGCAGCTTATCGAGATTGTGCGTGAACGCCTCAAAAACCCGACCCAAAAGCATCGTATGACGTTTGCAGAGCTG
AAGAGCCGTCATCGCGAATGA

Structures

Toxin

• AlphaFold DB: A0A0D6N6H9