Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 104325..105001 Replicon plasmid p183533
Accession NZ_CP036406
Organism Komagataeibacter saccharivorans strain JH1

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag KSAC_RS15690 Protein ID WP_110548428.1
Coordinates 104591..105001 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag KSAC_RS15685 Protein ID WP_110548427.1
Coordinates 104325..104594 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KSAC_RS15655 99594..100703 + 1110 WP_039733241.1 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase -
KSAC_RS15660 100763..101164 + 402 WP_039733238.1 VOC family protein -
KSAC_RS15665 101189..102016 + 828 WP_039733239.1 S-formylglutathione hydrolase -
KSAC_RS15670 102192..103088 - 897 WP_082084838.1 LysR family transcriptional regulator -
KSAC_RS15675 103205..103549 + 345 WP_171789708.1 hypothetical protein -
KSAC_RS15680 103546..104166 + 621 WP_039733240.1 NIPSNAP family protein -
KSAC_RS15685 104325..104594 + 270 WP_110548427.1 antitoxin Antitoxin
KSAC_RS15690 104591..105001 + 411 WP_110548428.1 type II toxin-antitoxin system VapC family toxin Toxin
KSAC_RS15695 105025..105306 + 282 WP_132306708.1 hypothetical protein -
KSAC_RS15700 105347..105765 + 419 Protein_104 transposase -
KSAC_RS15705 105821..107419 - 1599 Protein_105 ISL3 family transposase -
KSAC_RS15710 107501..107791 + 291 WP_165927374.1 transposase -
KSAC_RS15715 108022..109221 - 1200 WP_165927375.1 IS701 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..183533 183533


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-125)

Antitoxin

SpoVT-AbrB domain

(18-63)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 14287.57 Da        Isoelectric Point: 4.5083

>T119753 WP_110548428.1 NZ_CP036406:104591-105001 [Komagataeibacter saccharivorans]
VTALFMLDTNIISDLARNPQGMVARHIVSVGDDAICVSVITAAELRYGCVKKGSPKLMAQIEAILENTTVLALELPVDAE
YGRIRADLEAAGTPIGPNDLLIAAHACAVGAVLVTANTGEFERVCGLKVENWLATA

Download         Length: 411 bp

>T119753 NZ_CP036406:104591-105001 [Komagataeibacter saccharivorans]
GTGACCGCGCTCTTCATGTTGGACACCAATATCATCTCTGATCTGGCCCGGAATCCTCAGGGTATGGTCGCTCGACATAT
CGTGTCTGTCGGTGACGACGCGATATGCGTCAGCGTCATTACCGCCGCCGAACTTCGTTATGGCTGCGTGAAGAAGGGCT
CGCCGAAACTGATGGCGCAGATCGAGGCGATCCTGGAGAACACCACCGTGCTCGCCCTTGAGCTCCCTGTCGACGCTGAA
TACGGCCGCATCCGGGCGGATCTCGAGGCGGCCGGAACGCCGATCGGCCCGAACGATCTCTTAATTGCCGCTCATGCTTG
TGCCGTCGGCGCGGTACTCGTCACCGCCAACACTGGTGAGTTCGAGCGTGTATGTGGCCTGAAGGTCGAAAACTGGCTCG
CCACTGCGTAG

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10096.63 Da        Isoelectric Point: 5.6277

>AT119753 WP_110548427.1 NZ_CP036406:104325-104594 [Komagataeibacter saccharivorans]
MHYHRQLDASPPREAKLFRNNKSQAVRIPVDFELPGERVLIHREGSRLIIEPVPGKRLLAVLAELEPLPPEDAFPDVDST
LLPARDIDL

Download         Length: 270 bp

>AT119753 NZ_CP036406:104325-104594 [Komagataeibacter saccharivorans]
ATGCATTACCATCGCCAGCTGGATGCCTCGCCCCCGCGTGAGGCCAAACTCTTTCGGAACAACAAGAGCCAGGCGGTTCG
CATTCCGGTCGACTTCGAGCTTCCCGGTGAGCGGGTGCTGATACACCGGGAGGGGTCACGGCTAATCATCGAACCTGTGC
CTGGAAAGCGTTTGTTGGCCGTCCTTGCTGAACTGGAGCCACTACCACCCGAAGACGCTTTTCCCGATGTCGACAGCACA
CTTCTGCCGGCGCGGGACATCGACCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References