Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapC-mazE/PIN(toxin)
Location 3693766..3694518 Replicon chromosome
Accession NZ_CP036403
Organism Ornithinimicrobium sp. HY006

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag ESZ52_RS17040 Protein ID WP_131105970.1
Coordinates 3694084..3694518 (-) Length 145 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag ESZ52_RS17035 Protein ID WP_131105969.1
Coordinates 3693766..3694005 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ESZ52_RS17015 3688767..3689036 - 270 WP_131105965.1 hypothetical protein -
ESZ52_RS17020 3689289..3690098 - 810 WP_131105966.1 SWIM zinc finger family protein -
ESZ52_RS17025 3690091..3693285 - 3195 WP_131105967.1 DEAD/DEAH box helicase -
ESZ52_RS17030 3693440..3693766 - 327 WP_131105968.1 type II toxin-antitoxin system PemK/MazF family toxin -
ESZ52_RS17035 3693766..3694005 - 240 WP_131105969.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
ESZ52_RS17040 3694084..3694518 - 435 WP_131105970.1 PIN domain-containing protein Toxin
ESZ52_RS17045 3694515..3694748 - 234 WP_181010087.1 type II toxin-antitoxin system VapB family antitoxin -
ESZ52_RS19540 3694729..3694980 + 252 WP_202865369.1 hypothetical protein -
ESZ52_RS17055 3695269..3696612 - 1344 WP_202865487.1 TRAP transporter large permease -
ESZ52_RS17060 3696621..3697343 - 723 WP_131105973.1 TRAP transporter small permease -
ESZ52_RS17065 3697347..3698411 - 1065 WP_131105974.1 TRAP transporter substrate-binding protein DctP -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-131)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(9-48)


Sequences

Toxin        


Download         Length: 145 a.a.        Molecular weight: 15633.00 Da        Isoelectric Point: 6.9715

>T119752 WP_131105970.1 NZ_CP036403:c3694518-3694084 [Ornithinimicrobium sp. HY006]
VIAVDTNVLVYAHRADSPHHERASEVLRGLAAGRGTWAIPWPCLHEFLAVVTHPRIYRPPTTPAVAVEAVESLLALPNLR
LLSETTDHGSILARLLHVPGAVGPKVHDARIAAICLGHGVDALWSADRDFSWFPELRVLNPLTG

Download         Length: 435 bp

>T119752 NZ_CP036403:c3694518-3694084 [Ornithinimicrobium sp. HY006]
GTGATTGCGGTCGACACTAACGTCCTGGTCTACGCGCACCGCGCAGACAGTCCTCACCATGAGCGGGCATCCGAAGTATT
GCGGGGGCTCGCCGCCGGGCGGGGCACCTGGGCGATCCCCTGGCCGTGCCTGCACGAGTTCCTGGCTGTGGTCACTCACC
CGCGGATCTACCGGCCGCCGACCACGCCGGCCGTCGCGGTCGAGGCCGTCGAGTCCCTGCTCGCACTACCCAACCTCAGG
TTGCTGTCGGAGACGACCGACCACGGGTCGATCCTCGCCAGGCTGCTGCACGTACCCGGGGCGGTCGGCCCCAAGGTGCA
CGACGCCCGGATCGCGGCGATCTGTCTCGGCCACGGCGTGGACGCGCTGTGGTCGGCAGACCGCGACTTCTCGTGGTTCC
CCGAGCTCCGGGTCCTCAATCCGCTGACCGGGTGA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8935.84 Da        Isoelectric Point: 4.8616

>AT119752 WP_131105969.1 NZ_CP036403:c3694005-3693766 [Ornithinimicrobium sp. HY006]
MPKTRISTTVDADLMARARRAHAGTTDASVVEAALKALLREHRESEIDQAYERAFREHPQDTPDDWGDLDAFLDEAARR

Download         Length: 240 bp

>AT119752 NZ_CP036403:c3694005-3693766 [Ornithinimicrobium sp. HY006]
ATGCCCAAGACCCGGATCAGCACGACCGTGGATGCAGACCTGATGGCTCGAGCTCGCCGCGCCCACGCCGGCACCACGGA
CGCCTCCGTCGTCGAGGCGGCCCTGAAGGCGTTGCTCCGGGAGCACCGCGAGAGTGAGATCGACCAGGCCTACGAGCGGG
CGTTCCGCGAGCATCCGCAGGACACCCCTGATGACTGGGGCGACCTGGATGCCTTCCTCGACGAGGCCGCCAGACGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References