Detailed information of TA system TA119751

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazEF/MazF(toxin)
• Location: 3693440..3694005
• Replicon: chromosome
• Accession: NZ_CP036403
• Organism: Ornithinimicrobium sp. HY006

Toxin (Protein)

• Gene name: mazF
• Uniprot ID: -
• Locus tag: ESZ52_RS17030
• Protein ID: WP_131105968.1
• Coordinates: 3693440..3693766 (-)
• Length: 109 a.a.

Antitoxin (Protein)

• Gene name: mazE
• Uniprot ID: -
• Locus tag: ESZ52_RS17035
• Protein ID: WP_131105969.1
• Coordinates: 3693766..3694005 (-)
• Length: 80 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ESZ52_RS17015	3688767..3689036	-	270	WP_131105965.1	hypothetical protein	-
ESZ52_RS17020	3689289..3690098	-	810	WP_131105966.1	SWIM zinc finger family protein	-
ESZ52_RS17025	3690091..3693285	-	3195	WP_131105967.1	DEAD/DEAH box helicase	-
ESZ52_RS17030	3693440..3693766	-	327	WP_131105968.1	type II toxin-antitoxin system PemK/MazF family toxin	Toxin
ESZ52_RS17035	3693766..3694005	-	240	WP_131105969.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
ESZ52_RS17040	3694084..3694518	-	435	WP_131105970.1	PIN domain-containing protein	-
ESZ52_RS17045	3694515..3694748	-	234	WP_181010087.1	type II toxin-antitoxin system VapB family antitoxin	-
ESZ52_RS19540	3694729..3694980	+	252	WP_202865369.1	hypothetical protein	-
ESZ52_RS17055	3695269..3696612	-	1344	WP_202865487.1	TRAP transporter large permease	-
ESZ52_RS17060	3696621..3697343	-	723	WP_131105973.1	TRAP transporter small permease	-
ESZ52_RS17065	3697347..3698411	-	1065	WP_131105974.1	TRAP transporter substrate-binding protein DctP	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (6-101)

Antitoxin

• Bacterial antitoxin of type II TA system, VapB (9-48)

Sequences

Toxin

Protein

• Length: 109 a.a.
• Molecular weight: 11559.40 Da
• Isoelectric Point: 8.1466

>T119751 WP_131105968.1 NZ_CP036403:c3693766-3693440 [Ornithinimicrobium sp. HY006]
MHLPARGELWWADLAEAGARPVVVVGRDAAVRGRRRALVAPCSTAIRRLPSEVLLEPGQEPVHQRCVVQLDALTDLPVDV
LTRRRGGLSDAAMRQVCEAVTVAAGCTG

Nucleotide

• Length: 327 bp

>T119751 NZ_CP036403:c3693766-3693440 [Ornithinimicrobium sp. HY006]
ATGCACCTTCCCGCGAGAGGCGAGCTGTGGTGGGCGGACCTCGCCGAGGCCGGTGCCAGGCCGGTGGTCGTGGTAGGCCG
AGACGCGGCCGTCCGCGGACGTCGACGAGCACTGGTTGCGCCGTGCAGCACGGCCATCCGCCGGCTGCCGAGTGAGGTGC
TGCTGGAGCCGGGGCAGGAGCCGGTCCACCAGCGGTGCGTCGTGCAGCTTGACGCCCTCACCGACCTCCCCGTCGACGTC
CTCACGCGGCGGCGGGGAGGCCTGAGCGACGCCGCCATGCGGCAGGTCTGCGAGGCGGTGACTGTCGCGGCGGGATGCAC
CGGCTGA

Antitoxin

Protein

• Length: 80 a.a.
• Molecular weight: 8935.84 Da
• Isoelectric Point: 4.8616

>AT119751 WP_131105969.1 NZ_CP036403:c3694005-3693766 [Ornithinimicrobium sp. HY006]
MPKTRISTTVDADLMARARRAHAGTTDASVVEAALKALLREHRESEIDQAYERAFREHPQDTPDDWGDLDAFLDEAARR

Nucleotide

• Length: 240 bp

>AT119751 NZ_CP036403:c3694005-3693766 [Ornithinimicrobium sp. HY006]
ATGCCCAAGACCCGGATCAGCACGACCGTGGATGCAGACCTGATGGCTCGAGCTCGCCGCGCCCACGCCGGCACCACGGA
CGCCTCCGTCGTCGAGGCGGCCCTGAAGGCGTTGCTCCGGGAGCACCGCGAGAGTGAGATCGACCAGGCCTACGAGCGGG
CGTTCCGCGAGCATCCGCAGGACACCCCTGATGACTGGGGCGACCTGGATGCCTTCCTCGACGAGGCCGCCAGACGCTGA