119750

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 3482664..3483220 Replicon chromosome
Accession NZ_CP036403
Organism Ornithinimicrobium sp. HY006

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag ESZ52_RS15925 Protein ID WP_131105787.1
Coordinates 3482664..3482984 (-) Length 107 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag ESZ52_RS15930 Protein ID WP_131105788.1
Coordinates 3482987..3483220 (-) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ESZ52_RS15900 3478095..3479111 + 1017 WP_131106697.1 uroporphyrinogen-III C-methyltransferase -
ESZ52_RS15905 3479934..3480458 + 525 WP_131105783.1 SigE family RNA polymerase sigma factor -
ESZ52_RS15910 3480455..3481357 + 903 WP_131105784.1 hypothetical protein -
ESZ52_RS15915 3481494..3481739 - 246 WP_131105785.1 ribbon-helix-helix domain-containing protein -
ESZ52_RS15920 3481736..3481978 - 243 WP_131105786.1 hypothetical protein -
ESZ52_RS15925 3482664..3482984 - 321 WP_131105787.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
ESZ52_RS15930 3482987..3483220 - 234 WP_131105788.1 ribbon-helix-helix domain-containing protein Antitoxin
ESZ52_RS15935 3483346..3483684 + 339 WP_181010078.1 GNAT family N-acetyltransferase -
ESZ52_RS15940 3483895..3484134 - 240 WP_131105790.1 hypothetical protein -
ESZ52_RS15945 3484871..3485908 + 1038 WP_131105791.1 NADP-dependent oxidoreductase -
ESZ52_RS15950 3486126..3487022 + 897 WP_131106698.1 iron-containing redox enzyme family protein -
ESZ52_RS15955 3487019..3487258 + 240 WP_131105792.1 CDGSH iron-sulfur domain-containing protein -
ESZ52_RS15960 3487287..3487784 + 498 WP_131105793.1 DinB family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(10-93)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 107 a.a.        Molecular weight: 11425.32 Da        Isoelectric Point: 7.1663

>T119750 WP_131105787.1 NZ_CP036403:c3482984-3482664 [Ornithinimicrobium sp. HY006]
MREICLARLDKTRPVLVLTRDTARAVMTKVTVAPITSTVKGLSSEVPVGRANGLDHNSAVSIDNVLTIPADLLGRTLGFL
TPEQERHLARAIVLAYDLDVPLLGEP

Download         Length: 321 bp

>T119750 NZ_CP036403:c3482984-3482664 [Ornithinimicrobium sp. HY006]
TTGCGCGAGATCTGCCTGGCGCGGCTGGACAAGACCCGCCCCGTCCTGGTGCTCACCCGCGACACTGCCCGCGCCGTGAT
GACCAAGGTGACCGTGGCTCCCATCACGTCGACGGTCAAGGGGCTGTCCAGCGAAGTGCCGGTAGGACGTGCCAACGGGC
TGGACCACAACAGTGCTGTCTCGATCGACAACGTCCTGACCATCCCCGCCGACCTCCTGGGCCGGACGCTGGGCTTCCTC
ACGCCCGAGCAGGAGCGCCACCTGGCAAGAGCCATCGTGCTGGCGTACGACCTCGACGTGCCGTTGCTGGGGGAGCCGTG
A

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8362.48 Da        Isoelectric Point: 5.0176

>AT119750 WP_131105788.1 NZ_CP036403:c3483220-3482987 [Ornithinimicrobium sp. HY006]
VTTQIAVRLPDEMVRFLDRSVASGKAPSRAALVAAALEREMRLQAAQQDAQTLKKKGTADDLDELVTWSVAHATLDD

Download         Length: 234 bp

>AT119750 NZ_CP036403:c3483220-3482987 [Ornithinimicrobium sp. HY006]
GTGACGACACAGATCGCGGTACGGCTCCCTGATGAGATGGTTCGCTTTCTGGACCGGAGCGTGGCCAGTGGCAAGGCTCC
CAGCCGAGCGGCGCTGGTGGCCGCGGCCCTAGAGCGTGAGATGCGCCTGCAAGCCGCTCAGCAGGACGCCCAGACCCTGA
AGAAGAAGGGCACGGCCGATGACCTCGACGAGCTCGTCACTTGGTCCGTAGCCCACGCGACACTGGACGACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References