Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-PHD
Location 3054022..3054734 Replicon chromosome
Accession NZ_CP036403
Organism Ornithinimicrobium sp. HY006

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag ESZ52_RS14030 Protein ID WP_131105482.1
Coordinates 3054339..3054734 (+) Length 132 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag ESZ52_RS14025 Protein ID WP_181009926.1
Coordinates 3054022..3054339 (+) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ESZ52_RS13995 3049364..3050407 - 1044 WP_131105476.1 ABC transporter substrate-binding protein -
ESZ52_RS14000 3050556..3051101 - 546 WP_181009911.1 maleylpyruvate isomerase N-terminal domain-containing protein -
ESZ52_RS14005 3051227..3051808 + 582 WP_131105478.1 DUF3267 domain-containing protein -
ESZ52_RS14010 3051938..3052867 + 930 WP_131105479.1 acyl-CoA thioesterase -
ESZ52_RS14015 3052912..3053403 + 492 WP_131105480.1 glutathione peroxidase -
ESZ52_RS14020 3053445..3053888 - 444 WP_132974524.1 hypothetical protein -
ESZ52_RS14025 3054022..3054339 + 318 WP_181009926.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
ESZ52_RS14030 3054339..3054734 + 396 WP_131105482.1 type II toxin-antitoxin system VapC family toxin Toxin
ESZ52_RS14035 3054961..3056169 + 1209 WP_131106650.1 threonine ammonia-lyase -
ESZ52_RS14040 3056307..3057263 - 957 WP_181009912.1 HNH endonuclease -
ESZ52_RS14045 3057626..3059425 + 1800 WP_131106651.1 DUF2075 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-118)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(17-75)


Sequences

Toxin        


Download         Length: 132 a.a.        Molecular weight: 14489.74 Da        Isoelectric Point: 4.6674

>T119749 WP_131105482.1 NZ_CP036403:3054339-3054734 [Ornithinimicrobium sp. HY006]
MAYYLDTSALVKLVAPEPESEALRRWLEARSEALVTSDLARTELFRAVRRVRPELAPLARQVLDTLTVLRLETGVFEEAA
RLGPPELRSLDAVHLAAALLLEDDLLGVVTYDERLADATRLLGFPVVAPGR

Download         Length: 396 bp

>T119749 NZ_CP036403:3054339-3054734 [Ornithinimicrobium sp. HY006]
ATGGCCTACTACCTCGACACCTCCGCTCTCGTGAAGCTGGTCGCACCCGAGCCTGAGTCCGAGGCGCTCCGTCGGTGGCT
CGAGGCCCGATCTGAGGCGCTGGTGACCTCGGACCTTGCCCGGACAGAGCTCTTTCGCGCGGTCCGGCGCGTGCGGCCGG
AGCTCGCACCGTTGGCGCGACAGGTGCTGGACACGCTGACGGTCCTGCGGCTGGAGACCGGCGTCTTCGAAGAGGCTGCC
CGTCTGGGGCCACCGGAGCTGCGCTCGCTGGATGCGGTGCACCTGGCGGCGGCCCTCTTGCTCGAGGATGACCTGCTGGG
CGTGGTCACCTACGACGAACGGCTCGCGGACGCCACTCGGCTGCTCGGCTTCCCGGTCGTCGCACCGGGCCGCTGA

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11048.58 Da        Isoelectric Point: 9.3849

>AT119749 WP_181009926.1 NZ_CP036403:3054022-3054339 [Ornithinimicrobium sp. HY006]
MKVLPCSTFPEECTVAERTIGIRELKQNASAAVSRAAAGEVLVVTDHGRPVARLVPLGSSRASELVTAGLARSPRRALAN
LPRPAGAPSSALSQALGEDREDQRY

Download         Length: 318 bp

>AT119749 NZ_CP036403:3054022-3054339 [Ornithinimicrobium sp. HY006]
ATGAAAGTGCTACCGTGTAGCACATTTCCAGAGGAGTGCACCGTGGCAGAACGAACGATCGGCATCCGTGAGCTGAAGCA
GAACGCCTCGGCAGCGGTGTCACGCGCTGCCGCCGGCGAGGTGCTGGTGGTCACCGACCACGGCCGACCGGTCGCGCGAC
TGGTGCCTCTCGGCAGCAGTCGCGCGTCTGAGCTCGTGACCGCGGGACTCGCCCGCTCACCCAGACGGGCACTGGCGAAC
CTTCCTCGACCGGCGGGCGCGCCGAGCAGCGCGCTGTCGCAGGCTCTTGGCGAGGACCGCGAGGACCAGCGCTACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References