Detailed information of TA system TA119748

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-YefM
• Location: 2782444..2782985
• Replicon: chromosome
• Accession: NZ_CP036403
• Organism: Ornithinimicrobium sp. HY006

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: ESZ52_RS12760
• Protein ID: WP_131105262.1
• Coordinates: 2782444..2782722 (-)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: ESZ52_RS12765
• Protein ID: WP_131105263.1
• Coordinates: 2782719..2782985 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ESZ52_RS12745	2778859..2779875	+	1017	WP_131105259.1	hemolysin family protein	-
ESZ52_RS12750	2780080..2780580	+	501	WP_131105260.1	SigE family RNA polymerase sigma factor	-
ESZ52_RS12755	2780573..2782021	+	1449	WP_131105261.1	hypothetical protein	-
ESZ52_RS19325	2782263..2782403	-	141	WP_181009970.1	hypothetical protein	-
ESZ52_RS12760	2782444..2782722	-	279	WP_131105262.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
ESZ52_RS12765	2782719..2782985	-	267	WP_131105263.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
ESZ52_RS12770	2783146..2783622	-	477	WP_131105264.1	hypothetical protein	-
ESZ52_RS12775	2783700..2784248	-	549	WP_181009969.1	AAA family ATPase	-
ESZ52_RS12780	2784321..2784563	-	243	WP_131104656.1	toxin	-
ESZ52_RS12785	2784560..2784808	-	249	WP_131104655.1	ribbon-helix-helix protein, CopG family	-
ESZ52_RS12790	2784891..2785142	-	252	WP_131104654.1	hypothetical protein	-
ESZ52_RS12795	2785281..2785787	+	507	WP_131105266.1	hypothetical protein	-
ESZ52_RS12800	2786269..2787063	+	795	WP_181009902.1	HIRAN domain-containing protein	-
ESZ52_RS12805	2787118..2787708	+	591	WP_131105268.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (26-89)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-72)

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10414.08 Da
• Isoelectric Point: 10.9009

>T119748 WP_131105262.1 NZ_CP036403:c2782722-2782444 [Ornithinimicrobium sp. HY006]
MTSQPFELVVTPPAARAIRSKLPEPVAAAVIEFITGVLLDNPHRVGKQLRGELAGIHSARRGTYRVLYRINEHTHEVIVL
RIEHRRDVYGRP

Nucleotide

• Length: 279 bp

>T119748 NZ_CP036403:c2782722-2782444 [Ornithinimicrobium sp. HY006]
ATGACCTCCCAGCCGTTCGAGCTGGTCGTGACACCGCCAGCCGCACGGGCCATCCGATCGAAGCTGCCCGAGCCGGTTGC
TGCAGCCGTGATCGAGTTCATCACCGGGGTCCTGCTCGACAACCCACATCGCGTCGGAAAGCAACTGCGCGGTGAGCTGG
CAGGCATCCACTCCGCTCGACGCGGCACCTACCGAGTGCTCTACCGCATCAACGAGCACACCCACGAAGTCATCGTGCTT
CGCATCGAGCACCGCCGTGACGTCTACGGCCGGCCTTGA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 9853.92 Da
• Isoelectric Point: 4.4596

>AT119748 WP_131105263.1 NZ_CP036403:c2782985-2782719 [Ornithinimicrobium sp. HY006]
MSIESLREVRDHFSDVIDRVQREHERVTVTRNGRAAAVILSPEDLAQLEETLAVLSDPEALADIREADQAYRDGDVVRGA
DAVRALRQ

Nucleotide

• Length: 267 bp

>AT119748 NZ_CP036403:c2782985-2782719 [Ornithinimicrobium sp. HY006]
ATGAGCATCGAGTCCCTCCGCGAGGTCCGCGACCACTTCAGCGACGTGATCGACCGGGTACAACGCGAGCATGAGCGAGT
CACGGTGACCCGCAACGGAAGGGCAGCCGCGGTGATCCTCAGCCCCGAGGACTTGGCCCAGCTGGAGGAAACTTTGGCGG
TGCTCAGCGATCCCGAGGCCTTGGCCGACATCCGAGAGGCCGACCAGGCCTACCGAGACGGCGACGTCGTCCGCGGAGCC
GACGCGGTCCGCGCGCTGCGCCAATGA