Detailed information of TA system TA119747

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazEF/MazF(toxin)
• Location: 2317146..2317710
• Replicon: chromosome
• Accession: NZ_CP036403
• Organism: Ornithinimicrobium sp. HY006

Toxin (Protein)

• Gene name: mazF
• Uniprot ID: -
• Locus tag: ESZ52_RS10600
• Protein ID: WP_131104913.1
• Coordinates: 2317146..2317493 (-)
• Length: 116 a.a.

Antitoxin (Protein)

• Gene name: mazE
• Uniprot ID: -
• Locus tag: ESZ52_RS10605
• Protein ID: WP_131104914.1
• Coordinates: 2317480..2317710 (-)
• Length: 77 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ESZ52_RS10570	2313830..2314831	-	1002	Protein_2109	IS3 family transposase	-
ESZ52_RS19475	2314828..2315190	-	363	WP_202865322.1	transposase	-
ESZ52_RS10580	2315799..2316113	+	315	Protein_2111	type II toxin-antitoxin system RelE/ParE family toxin	-
ESZ52_RS10585	2316103..2316399	+	297	WP_131104910.1	putative addiction module antidote protein	-
ESZ52_RS10590	2316466..2316786	+	321	WP_131104911.1	nucleotidyltransferase family protein	-
ESZ52_RS10595	2316783..2317103	+	321	WP_131104912.1	DUF86 domain-containing protein	-
ESZ52_RS10600	2317146..2317493	-	348	WP_131104913.1	type II toxin-antitoxin system PemK/MazF family toxin	Toxin
ESZ52_RS10605	2317480..2317710	-	231	WP_131104914.1	ribbon-helix-helix domain-containing protein	Antitoxin
ESZ52_RS10610	2317780..2317944	-	165	Protein_2117	VapC toxin family PIN domain ribonuclease	-
ESZ52_RS10615	2317935..2319008	-	1074	WP_131103283.1	IS630 family transposase	-
ESZ52_RS10620	2319060..2319308	-	249	Protein_2119	VapC toxin family PIN domain ribonuclease	-
ESZ52_RS10625	2319305..2319553	-	249	WP_131104915.1	type II toxin-antitoxin system prevent-host-death family antitoxin	-
ESZ52_RS10630	2319850..2320863	+	1014	WP_131104916.1	DMT family transporter	-
ESZ52_RS10635	2321040..2321972	-	933	WP_131104917.1	NADP-dependent oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	2316103..2327814	11711
	-	flank	IS/Tn	-	-	2317935..2319008	1073

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (3-113)

Antitoxin

• Ribbon-helix-helix protein, CopG (3-38)

Sequences

Toxin

Protein

• Length: 116 a.a.
• Molecular weight: 12545.53 Da
• Isoelectric Point: 11.4911

>T119747 WP_131104913.1 NZ_CP036403:c2317493-2317146 [Ornithinimicrobium sp. HY006]
MLRGEILLVDLDPVRGSEANKRRPAVLVSNDRANTMAQRLGRGVVTVVPVTSNVERVFPFQALLPADETGLRVDSKAQAE
QVRSVAVERVGTAVGRVPPRLMAAVDEALRIHLQR

Nucleotide

• Length: 348 bp

>T119747 NZ_CP036403:c2317493-2317146 [Ornithinimicrobium sp. HY006]
ATGCTGCGCGGTGAGATCCTTCTCGTCGATCTGGATCCAGTGCGCGGTAGCGAGGCCAATAAGCGGCGTCCCGCGGTGCT
CGTCAGCAATGATCGGGCGAACACCATGGCTCAACGACTCGGTCGTGGAGTAGTCACCGTCGTGCCCGTGACCAGCAACG
TGGAGCGGGTCTTCCCGTTCCAGGCGTTGCTGCCGGCTGACGAGACAGGACTGCGGGTGGACTCCAAGGCCCAGGCGGAG
CAGGTGCGCTCGGTCGCAGTCGAGAGGGTCGGTACTGCAGTAGGCCGGGTGCCGCCCCGCCTCATGGCTGCGGTCGACGA
AGCGTTGCGAATCCATCTGCAGCGATGA

Antitoxin

Protein

• Length: 77 a.a.
• Molecular weight: 8155.83 Da
• Isoelectric Point: 3.8308

>AT119747 WP_131104914.1 NZ_CP036403:c2317710-2317480 [Ornithinimicrobium sp. HY006]
MKVSVSLSEEDLAALDRYVEEAGLESRSAGVQQAIRRLQDPQLEAAYAAAWEEWAVAGDEDAWASASSDGLTDAAR

Nucleotide

• Length: 231 bp

>AT119747 NZ_CP036403:c2317710-2317480 [Ornithinimicrobium sp. HY006]
ATGAAGGTGAGCGTAAGTCTGAGCGAGGAAGATCTCGCGGCCCTCGACCGGTACGTCGAAGAAGCTGGCCTCGAGTCGAG
GTCCGCTGGCGTCCAGCAGGCCATCCGCCGCCTGCAAGACCCGCAGCTGGAGGCGGCCTATGCCGCCGCCTGGGAGGAGT
GGGCCGTCGCGGGGGACGAAGACGCGTGGGCGTCAGCGTCCTCGGACGGGCTGACCGATGCTGCGCGGTGA