Detailed information of TA system TA119746

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazEF/PemK-MazE
• Location: 2027516..2028045
• Replicon: chromosome
• Accession: NZ_CP036403
• Organism: Ornithinimicrobium sp. HY006

Toxin (Protein)

• Gene name: mazF
• Uniprot ID: -
• Locus tag: ESZ52_RS09195
• Protein ID: WP_131104677.1
• Coordinates: 2027719..2028045 (+)
• Length: 109 a.a.

Antitoxin (Protein)

• Gene name: mazE
• Uniprot ID: -
• Locus tag: ESZ52_RS09190
• Protein ID: WP_131104416.1
• Coordinates: 2027516..2027722 (+)
• Length: 69 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ESZ52_RS09175	2022750..2024039	+	1290	WP_131104675.1	ISL3 family transposase	-
ESZ52_RS09180	2024196..2025626	-	1431	WP_131104676.1	DUF4041 domain-containing protein	-
ESZ52_RS09185	2026018..2027202	-	1185	WP_131104668.1	IS110 family transposase	-
ESZ52_RS09190	2027516..2027722	+	207	WP_131104416.1	DUF3018 family protein	Antitoxin
ESZ52_RS09195	2027719..2028045	+	327	WP_131104677.1	type II toxin-antitoxin system PemK/MazF family toxin	Toxin
ESZ52_RS09200	2028134..2028691	-	558	WP_131104678.1	hypothetical protein	-
ESZ52_RS09205	2028843..2029277	+	435	WP_131104679.1	hypothetical protein	-
ESZ52_RS09210	2029499..2029855	+	357	WP_131104680.1	hypothetical protein	-
ESZ52_RS09215	2030112..2031416	-	1305	WP_181010015.1	Nramp family divalent metal transporter	-
ESZ52_RS09220	2031659..2032162	-	504	WP_131104682.1	OsmC family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	1994376..2029855	35479

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (2-103)

Antitoxin

• Antitoxin MazE-like (5-66)

Sequences

Toxin

Protein

• Length: 109 a.a.
• Molecular weight: 11678.48 Da
• Isoelectric Point: 8.7376

>T119746 WP_131104677.1 NZ_CP036403:2027719-2028045 [Ornithinimicrobium sp. HY006]
VRRGELWTVAGGVYASKPRPALIVQDDLFAGTTSVTVAPLTTTLVDAPLLRVPVSADDRTGLQHESQVMIDKITTVRREN
VGSRVGRLAPENLVEVERALMAFLGLAR

Nucleotide

• Length: 327 bp

>T119746 NZ_CP036403:2027719-2028045 [Ornithinimicrobium sp. HY006]
GTGAGGCGCGGGGAGCTGTGGACCGTCGCCGGGGGTGTGTACGCGTCCAAGCCCAGGCCCGCGCTGATCGTGCAAGACGA
CCTCTTCGCCGGCACCACATCGGTGACCGTGGCGCCGCTGACGACCACCTTGGTCGACGCCCCTCTGCTACGGGTGCCTG
TCTCCGCCGACGACCGCACCGGCCTTCAACATGAAAGCCAGGTCATGATCGACAAGATCACCACAGTGCGCCGCGAGAAC
GTCGGTTCCCGCGTCGGTCGGCTCGCGCCTGAAAACCTTGTGGAGGTCGAGCGAGCCCTTATGGCGTTTCTCGGCCTAGC
CAGATAG

Antitoxin

Protein

• Length: 69 a.a.
• Molecular weight: 8113.11 Da
• Isoelectric Point: 10.3629

>AT119746 WP_131104416.1 NZ_CP036403:2027516-2027722 [Ornithinimicrobium sp. HY006]
MTVKHRVSEYRRRMRARGLRPVQIWVPDVRSERFVQEARRQAALVARSDQQSDDQQFVEAVAVSWDEE

Nucleotide

• Length: 207 bp

>AT119746 NZ_CP036403:2027516-2027722 [Ornithinimicrobium sp. HY006]
ATGACGGTGAAGCATCGAGTCAGTGAGTACCGGCGCCGGATGCGCGCACGCGGCCTGCGGCCGGTGCAGATTTGGGTGCC
CGATGTGCGAAGTGAGCGATTCGTGCAAGAGGCGCGCCGTCAGGCGGCGCTGGTCGCCAGATCGGACCAGCAGTCCGACG
ACCAGCAGTTCGTCGAGGCGGTTGCCGTCTCCTGGGATGAGGAGTGA