Detailed information of TA system TA119745

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazEF/PemK-MazE
• Location: 1689363..1689892
• Replicon: chromosome
• Accession: NZ_CP036403
• Organism: Ornithinimicrobium sp. HY006

Toxin (Protein)

• Gene name: mazF
• Uniprot ID: -
• Locus tag: ESZ52_RS07715
• Protein ID: WP_131104417.1
• Coordinates: 1689566..1689892 (+)
• Length: 109 a.a.

Antitoxin (Protein)

• Gene name: mazE
• Uniprot ID: -
• Locus tag: ESZ52_RS07710
• Protein ID: WP_131104416.1
• Coordinates: 1689363..1689569 (+)
• Length: 69 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ESZ52_RS07695	1685606..1686361	-	756	WP_131104413.1	hypothetical protein	-
ESZ52_RS07700	1686688..1687830	+	1143	WP_131104414.1	hypothetical protein	-
ESZ52_RS07705	1688004..1689158	+	1155	WP_131104415.1	hypothetical protein	-
ESZ52_RS07710	1689363..1689569	+	207	WP_131104416.1	DUF3018 family protein	Antitoxin
ESZ52_RS07715	1689566..1689892	+	327	WP_131104417.1	type II toxin-antitoxin system PemK/MazF family toxin	Toxin
ESZ52_RS07720	1690846..1691718	+	873	WP_131106508.1	ABC transporter ATP-binding protein	-
ESZ52_RS07725	1691781..1694000	+	2220	WP_131104418.1	FtsX-like permease family protein	-
ESZ52_RS07730	1694128..1694550	+	423	WP_131104419.1	helix-turn-helix domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	1672473..1699679	27206

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (2-103)

Antitoxin

• Antitoxin MazE-like (5-66)

Sequences

Toxin

Protein

• Length: 109 a.a.
• Molecular weight: 11750.55 Da
• Isoelectric Point: 7.0141

>T119745 WP_131104417.1 NZ_CP036403:1689566-1689892 [Ornithinimicrobium sp. HY006]
VRRGELWTVAGDVYASKPRPALIVQDDLFAGTTSVTVAPLTTTLVDAPLLRVPVSADDRTGLQHESQVMIDKITTVRREN
VGTRVGRLAPENLVEVERALMAFLGLAR

Nucleotide

• Length: 327 bp

>T119745 NZ_CP036403:1689566-1689892 [Ornithinimicrobium sp. HY006]
GTGAGGCGCGGGGAGCTGTGGACCGTCGCCGGGGATGTGTACGCGTCCAAGCCCAGGCCCGCGCTGATCGTGCAAGACGA
CCTCTTCGCCGGCACCACATCGGTGACCGTGGCGCCGCTGACGACCACCTTGGTCGACGCCCCTCTGCTACGGGTGCCTG
TCTCCGCCGACGACCGCACCGGCCTTCAACATGAAAGCCAGGTGATGATCGACAAGATCACCACAGTGCGCCGCGAGAAC
GTCGGTACCCGCGTCGGTCGGCTCGCGCCTGAAAACCTTGTGGAGGTCGAGCGAGCCCTTATGGCGTTTCTCGGCCTAGC
CAGATAG

Antitoxin

Protein

• Length: 69 a.a.
• Molecular weight: 8113.11 Da
• Isoelectric Point: 10.3629

>AT119745 WP_131104416.1 NZ_CP036403:1689363-1689569 [Ornithinimicrobium sp. HY006]
MTVKHRVSEYRRRMRARGLRPVQIWVPDVRSERFVQEARRQAALVARSDQQSDDQQFVEAVAVSWDEE

Nucleotide

• Length: 207 bp

>AT119745 NZ_CP036403:1689363-1689569 [Ornithinimicrobium sp. HY006]
ATGACGGTGAAGCATCGAGTCAGTGAGTACCGGCGCCGGATGCGCGCACGCGGCCTGCGGCCGGTGCAGATTTGGGTGCC
CGATGTGCGAAGTGAGCGATTCGTACAAGAGGCGCGCCGTCAGGCGGCGCTGGTCGCCAGATCGGACCAGCAGTCCGACG
ACCAGCAGTTCGTCGAGGCGGTTGCCGTCTCCTGGGATGAGGAGTGA