Detailed information of TA system TA119741

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN(toxin)
• Location: 419267..419940
• Replicon: chromosome
• Accession: NZ_CP036402
• Organism: Egibacter rhizosphaerae strain EGI 80759

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: ER308_RS01930
• Protein ID: WP_131153445.1
• Coordinates: 419512..419940 (+)
• Length: 143 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: ER308_RS01925
• Protein ID: WP_131153444.1
• Coordinates: 419267..419515 (+)
• Length: 83 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ER308_RS01900	414554..415653	+	1100	Protein_373	ISL3 family transposase	-
ER308_RS01905	415997..417079	-	1083	WP_131153440.1	IS630 family transposase	-
ER308_RS01910	417308..417688	-	381	WP_131153441.1	metalloregulator ArsR/SmtB family transcription factor	-
ER308_RS01915	417685..418320	-	636	WP_131153442.1	SRPBCC family protein	-
ER308_RS01920	418525..419244	+	720	WP_131153443.1	DNA alkylation repair protein	-
ER308_RS01925	419267..419515	+	249	WP_131153444.1	antitoxin	Antitoxin
ER308_RS01930	419512..419940	+	429	WP_131153445.1	type II toxin-antitoxin system VapC family toxin	Toxin
ER308_RS01935	420025..421077	-	1053	WP_205745841.1	ABC transporter substrate-binding protein	-
ER308_RS01940	421121..422056	-	936	WP_131153446.1	ABC transporter ATP-binding protein	-
ER308_RS01945	422071..423159	-	1089	WP_131153447.1	iron ABC transporter permease	-
ER308_RS01950	423171..424148	-	978	WP_205745842.1	iron chelate uptake ABC transporter family permease subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	415489..415653	164

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain toxin (2-138)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 143 a.a.
• Molecular weight: 15702.99 Da
• Isoelectric Point: 6.7611

>T119741 WP_131153445.1 NZ_CP036402:419512-419940 [Egibacter rhizosphaerae]
VKLVDANVLLYAVNVDAERHKPSRRWLDRALSGQDTVAFAWVVLLAFVRLATRDGLFPSPLTIDDAMDRVDGWLAAPPAV
VVHPTLEHARLVRDLLRGLGAGGNLVNDAHLAALAIEHRGTIVSFDHDFDRFEGVRREAPRI

Nucleotide

• Length: 429 bp

>T119741 NZ_CP036402:419512-419940 [Egibacter rhizosphaerae]
GTGAAGCTCGTCGACGCGAACGTCCTGCTGTACGCGGTCAACGTGGACGCCGAGCGCCACAAGCCGTCACGACGATGGCT
CGACCGAGCCTTGTCCGGGCAGGACACGGTCGCGTTCGCGTGGGTCGTCCTGCTCGCGTTCGTGCGCCTTGCCACCCGCG
ACGGGCTGTTCCCCTCGCCGTTGACGATCGACGACGCGATGGACCGTGTCGACGGGTGGCTGGCCGCCCCACCGGCCGTC
GTGGTGCACCCCACCCTCGAGCACGCGCGACTCGTGCGGGACCTCCTTCGCGGGCTGGGAGCAGGCGGCAACCTCGTCAA
CGACGCGCACCTCGCGGCGCTGGCGATCGAGCACCGCGGCACGATCGTGTCCTTCGACCACGACTTCGACCGCTTCGAGG
GCGTGCGCCGAGAGGCACCCCGGATCTGA

Antitoxin

Protein

• Length: 83 a.a.
• Molecular weight: 9090.15 Da
• Isoelectric Point: 4.8283

>AT119741 WP_131153444.1 NZ_CP036402:419267-419515 [Egibacter rhizosphaerae]
MRTTVTLDPDTAQIVRRRMRERGMTFKEALNDVIRSGAGDTAEEFQTPTASLGRPSVNLDRALQVAGDLEDEDLVRKERA
GS

Nucleotide

• Length: 249 bp

>AT119741 NZ_CP036402:419267-419515 [Egibacter rhizosphaerae]
ATGCGGACGACCGTGACCCTGGACCCCGACACCGCGCAGATCGTGCGGCGTCGGATGCGCGAGCGCGGGATGACGTTCAA
GGAAGCGCTCAACGACGTCATCCGCAGCGGCGCGGGGGATACTGCCGAGGAGTTCCAGACACCGACCGCCTCGCTCGGAC
GCCCGTCGGTGAACCTCGACCGCGCGCTGCAGGTCGCCGGTGACCTCGAGGACGAGGACCTTGTTCGCAAGGAGCGGGCC
GGCTCGTGA