Detailed information of TA system TA119737

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PanAT/DUF4065(antitoxin)
• Location: 18081..19290
• Replicon: chromosome
• Accession: NZ_CP036398
• Organism: Helicobacter pylori strain 8C10

Toxin (Protein)

• Gene name: panT
• Uniprot ID: -
• Locus tag: EYC10_RS00070
• Protein ID: WP_000403000.1
• Coordinates: 18508..19290 (+)
• Length: 261 a.a.

Antitoxin (Protein)

• Gene name: panA
• Uniprot ID: -
• Locus tag: EYC10_RS00065
• Protein ID: WP_000245669.1
• Coordinates: 18081..18518 (+)
• Length: 146 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EYC10_RS00060	16232..17857	+	1626	Protein_10	RNA-directed DNA polymerase	-
EYC10_RS00065	18081..18518	+	438	WP_000245669.1	SocA family protein	Antitoxin
EYC10_RS00070	18508..19290	+	783	WP_000403000.1	hypothetical protein	Toxin
EYC10_RS00075	19517..20704	-	1188	WP_000411598.1	transcription termination/antitermination protein NusA	-
EYC10_RS00080	20792..21952	-	1161	WP_000159862.1	L-seryl-tRNA(Sec) selenium transferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Antitoxin SocA-like, Panacea domain (24-119)

Sequences

Toxin

Protein

• Length: 261 a.a.
• Molecular weight: 30633.85 Da
• Isoelectric Point: 9.2969

>T119737 WP_000403000.1 NZ_CP036398:18508-19290 [Helicobacter pylori]
MEIKEEDKDKNLEKIIVLLCEEGDLSSQKDQIIKDLKEIYKGEYKHKYSKITTIILNSTRDKEQAFMMLTQNIKTLKEIQ
DNKEVESIKPKLEKLYDHMNLECIRLQDFDEKMSRVKNVSIKLEDELNKNYKKLSEELNKQQTQYITILGIFASIVLTFV
GGLAFSTSVLSNIDKANAYRLVFVMAFIALFFGNILYLLFSFLSKISLSEEKKDKQENFFKKPIFWFNLMVIILFVIGFV
GERIDRQYKAQISKDFKRPR

Nucleotide

• Length: 783 bp

>T119737 NZ_CP036398:18508-19290 [Helicobacter pylori]
ATGGAAATTAAAGAAGAGGATAAAGATAAAAATCTAGAAAAAATTATTGTATTGCTGTGCGAAGAGGGGGATTTGTCCAG
CCAAAAAGATCAAATCATCAAAGATCTCAAAGAAATCTATAAAGGAGAATACAAGCATAAATATTCAAAAATCACAACTA
TTATTTTAAATTCCACAAGGGATAAAGAGCAAGCCTTTATGATGCTCACACAAAATATAAAGACACTCAAAGAGATTCAA
GATAATAAAGAAGTTGAAAGCATTAAACCAAAACTAGAAAAACTTTATGATCACATGAATTTAGAGTGTATCAGACTGCA
AGATTTTGATGAGAAAATGAGTAGAGTTAAAAATGTTTCTATAAAGTTAGAAGATGAACTAAATAAAAACTATAAAAAAT
TAAGCGAAGAATTGAATAAGCAACAAACACAATATATAACAATTTTAGGTATTTTTGCCTCTATTGTTTTAACATTTGTT
GGGGGATTGGCGTTTTCCACTTCTGTTTTATCAAATATTGACAAAGCGAACGCCTATCGTTTGGTTTTTGTTATGGCTTT
TATAGCTTTATTTTTTGGGAATATTTTGTATCTGCTTTTTTCTTTTTTATCAAAAATATCCTTATCAGAAGAGAAAAAAG
ATAAACAAGAAAATTTTTTCAAAAAACCTATTTTTTGGTTTAATCTAATGGTTATAATCCTATTTGTGATTGGTTTTGTG
GGAGAGAGAATTGATAGGCAATATAAAGCTCAGATTTCTAAAGATTTTAAAAGACCAAGATAA

Antitoxin

Protein

• Length: 146 a.a.
• Molecular weight: 17270.35 Da
• Isoelectric Point: 5.7254

>AT119737 WP_000245669.1 NZ_CP036398:18081-18518 [Helicobacter pylori]
MVNALELAKYILKHSNKELSNLELQKTLYFTELDYIKKFDKHLVSDDFEAWKYGPVAREVYYEYRNYGANSIDKPKEETL
SQNLREDELETINRSIEKCNEKSYWDLVKESHKEDGAWHKSFKEDRKEIISKDLIKQEAKQANGN

Nucleotide

• Length: 438 bp

>AT119737 NZ_CP036398:18081-18518 [Helicobacter pylori]
ATGGTCAATGCTTTGGAATTAGCAAAATATATTCTTAAGCATTCCAACAAAGAATTGAGCAACTTAGAATTGCAAAAAAC
TTTGTATTTCACAGAGCTTGACTATATTAAAAAGTTTGACAAACACCTAGTTTCTGATGATTTTGAAGCTTGGAAATACG
GACCTGTTGCAAGGGAAGTGTATTATGAATATCGCAATTATGGTGCCAATTCTATTGACAAACCTAAAGAAGAAACGCTC
TCACAAAATCTTAGAGAAGATGAACTTGAAACCATCAATCGCTCCATAGAAAAATGCAACGAAAAATCCTATTGGGATTT
AGTGAAAGAGAGTCATAAAGAAGATGGCGCTTGGCATAAAAGCTTCAAAGAAGATAGAAAAGAAATCATTAGCAAAGATT
TGATCAAACAAGAAGCAAAACAAGCAAATGGAAATTAA