Detailed information of TA system TA119736

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ(toxin)
• Location: 886096..886720
• Replicon: chromosome
• Accession: NZ_CP036397
• Organism: Helicobacter pylori strain 12A3

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: EYC11_RS04155
• Protein ID: WP_000916179.1
• Coordinates: 886096..886362 (-)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A1Q2RV02
• Locus tag: EYC11_RS04160
• Protein ID: WP_001133866.1
• Coordinates: 886343..886720 (-)
• Length: 126 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EYC11_RS04135	882744..883511	-	768	WP_000242367.1	ABC transporter ATP-binding protein	-
EYC11_RS04140	883511..884491	-	981	WP_000921437.1	iron ABC transporter permease	-
EYC11_RS04145	884484..885326	-	843	WP_188348635.1	SDR family oxidoreductase	-
EYC11_RS04150	885467..885991	+	525	WP_001120211.1	acyl-CoA thioesterase	-
EYC11_RS04155	886096..886362	-	267	WP_000916179.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	Toxin
EYC11_RS04160	886343..886720	-	378	WP_001133866.1	hypothetical protein	Antitoxin
EYC11_RS04165	887067..889151	-	2085	WP_188348636.1	Hop family adhesin BabB	-
EYC11_RS04170	889681..889938	-	258	WP_000440197.1	30S ribosomal protein S18	-
EYC11_RS04175	889962..890507	-	546	WP_000482461.1	single-stranded DNA-binding protein	-
EYC11_RS04180	890517..890957	-	441	WP_001216703.1	30S ribosomal protein S6	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (3-88)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10329.21 Da
• Isoelectric Point: 9.6292

>T119736 WP_000916179.1 NZ_CP036397:c886362-886096 [Helicobacter pylori]
VLKLNLKKSFQKDFDKLLLNGFDDSVLNKVILSLRKKEPLDPQFQDHALKGKWKPFRECHIKPDILLVYLVKDDELILVR
LGSHSELF

Nucleotide

• Length: 267 bp

>T119736 NZ_CP036397:c886362-886096 [Helicobacter pylori]
GTGTTGAAACTCAACCTTAAAAAATCTTTTCAAAAAGATTTTGATAAATTACTTTTGAATGGGTTTGATGATAGCGTTTT
GAATAAGGTCATTCTGTCTTTGAGAAAGAAAGAACCACTAGACCCCCAATTCCAAGATCATGCTTTAAAGGGGAAGTGGA
AACCTTTTAGGGAATGCCACATTAAACCTGATATTTTGCTTGTGTATTTAGTGAAAGATGATGAGCTTATTTTAGTAAGG
CTAGGCAGTCATAGCGAGCTGTTTTAA

Antitoxin

Protein

• Length: 126 a.a.
• Molecular weight: 14719.74 Da
• Isoelectric Point: 9.0037

>AT119736 WP_001133866.1 NZ_CP036397:c886720-886343 [Helicobacter pylori]
MPNSPTKKDYTQYSEKQLFNLINQLEQKIKKMQNDRASFKEKMAKELEKRDQNFKDKIDALNKLLQKISQAFDDKRDCCL
GRKIPNLETQQAMRDALNKETDLIVEDFSSYSDERKRALGVETQP

Nucleotide

• Length: 378 bp

>AT119736 NZ_CP036397:c886720-886343 [Helicobacter pylori]
ATGCCTAATTCTCCCACCAAAAAAGACTACACACAATACAGCGAAAAACAGCTTTTTAACTTAATCAACCAATTAGAGCA
AAAAATCAAAAAGATGCAAAATGATAGAGCTTCTTTTAAAGAAAAAATGGCTAAAGAATTGGAAAAAAGGGATCAAAACT
TTAAGGATAAAATAGACGCATTAAATAAACTCTTGCAAAAAATCAGCCAAGCTTTTGATGATAAAAGAGATTGTTGTTTG
GGGCGCAAGATCCCAAACCTTGAAACGCAACAAGCCATGAGAGATGCGCTTAACAAAGAAACCGATTTGATTGTTGAGGA
TTTTTCTAGTTATAGCGATGAAAGAAAAAGGGCGTTAGGTGTTGAAACTCAACCTTAA

Structures

Antitoxin

• AlphaFold DB: A0A1Q2RV02