Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PanAT/DUF4065(antitoxin)
Location 18084..19293 Replicon chromosome
Accession NZ_CP036397
Organism Helicobacter pylori strain 12A3

Toxin (Protein)


Gene name panT Uniprot ID -
Locus tag EYC11_RS00070 Protein ID WP_000403000.1
Coordinates 18511..19293 (+) Length 261 a.a.

Antitoxin (Protein)


Gene name panA Uniprot ID -
Locus tag EYC11_RS00065 Protein ID WP_000245669.1
Coordinates 18084..18521 (+) Length 146 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EYC11_RS00060 16235..17860 + 1626 Protein_10 RNA-directed DNA polymerase -
EYC11_RS00065 18084..18521 + 438 WP_000245669.1 SocA family protein Antitoxin
EYC11_RS00070 18511..19293 + 783 WP_000403000.1 hypothetical protein Toxin
EYC11_RS00075 19520..20707 - 1188 WP_000411598.1 transcription termination/antitermination protein NusA -
EYC11_RS00080 20795..21955 - 1161 WP_000159862.1 L-seryl-tRNA(Sec) selenium transferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Antitoxin SocA-like, Panacea domain

(24-119)


Sequences

Toxin        


Download         Length: 261 a.a.        Molecular weight: 30633.85 Da        Isoelectric Point: 9.2969

>T119735 WP_000403000.1 NZ_CP036397:18511-19293 [Helicobacter pylori]
MEIKEEDKDKNLEKIIVLLCEEGDLSSQKDQIIKDLKEIYKGEYKHKYSKITTIILNSTRDKEQAFMMLTQNIKTLKEIQ
DNKEVESIKPKLEKLYDHMNLECIRLQDFDEKMSRVKNVSIKLEDELNKNYKKLSEELNKQQTQYITILGIFASIVLTFV
GGLAFSTSVLSNIDKANAYRLVFVMAFIALFFGNILYLLFSFLSKISLSEEKKDKQENFFKKPIFWFNLMVIILFVIGFV
GERIDRQYKAQISKDFKRPR

Download         Length: 783 bp

>T119735 NZ_CP036397:18511-19293 [Helicobacter pylori]
ATGGAAATTAAAGAAGAGGATAAAGATAAAAATCTAGAAAAAATTATTGTATTGCTGTGCGAAGAGGGGGATTTGTCCAG
CCAAAAAGATCAAATCATCAAAGATCTCAAAGAAATCTATAAAGGAGAATACAAGCATAAATATTCAAAAATCACAACTA
TTATTTTAAATTCCACAAGGGATAAAGAGCAAGCCTTTATGATGCTCACACAAAATATAAAGACACTCAAAGAGATTCAA
GATAATAAAGAAGTTGAAAGCATTAAACCAAAACTAGAAAAACTTTATGATCACATGAATTTAGAGTGTATCAGACTGCA
AGATTTTGATGAGAAAATGAGTAGAGTTAAAAATGTTTCTATAAAGTTAGAAGATGAACTAAATAAAAACTATAAAAAAT
TAAGCGAAGAATTGAATAAGCAACAAACACAATATATAACAATTTTAGGTATTTTTGCCTCTATTGTTTTAACATTTGTT
GGGGGATTGGCGTTTTCCACTTCTGTTTTATCAAATATTGACAAAGCGAACGCCTATCGTTTGGTTTTTGTTATGGCTTT
TATAGCTTTATTTTTTGGGAATATTTTGTATCTGCTTTTTTCTTTTTTATCAAAAATATCCTTATCAGAAGAGAAAAAAG
ATAAACAAGAAAATTTTTTCAAAAAACCTATTTTTTGGTTTAATCTAATGGTTATAATCCTATTTGTGATTGGTTTTGTG
GGAGAGAGAATTGATAGGCAATATAAAGCTCAGATTTCTAAAGATTTTAAAAGACCAAGATAA

Antitoxin


Download         Length: 146 a.a.        Molecular weight: 17270.35 Da        Isoelectric Point: 5.7254

>AT119735 WP_000245669.1 NZ_CP036397:18084-18521 [Helicobacter pylori]
MVNALELAKYILKHSNKELSNLELQKTLYFTELDYIKKFDKHLVSDDFEAWKYGPVAREVYYEYRNYGANSIDKPKEETL
SQNLREDELETINRSIEKCNEKSYWDLVKESHKEDGAWHKSFKEDRKEIISKDLIKQEAKQANGN

Download         Length: 438 bp

>AT119735 NZ_CP036397:18084-18521 [Helicobacter pylori]
ATGGTCAATGCTTTGGAATTAGCAAAATATATTCTTAAGCATTCCAACAAAGAATTGAGCAACTTAGAATTGCAAAAAAC
TTTGTATTTCACAGAGCTTGACTATATTAAAAAGTTTGACAAACACCTAGTTTCTGATGATTTTGAAGCTTGGAAATACG
GACCTGTTGCAAGGGAAGTGTATTATGAATATCGCAATTATGGTGCCAATTCTATTGACAAACCTAAAGAAGAAACGCTC
TCACAAAATCTTAGAGAAGATGAACTTGAAACCATCAATCGCTCCATAGAAAAATGCAACGAAAAATCCTATTGGGATTT
AGTGAAAGAGAGTCATAAAGAAGATGGCGCTTGGCATAAAAGCTTCAAAGAAGATAGAAAAGAAATCATTAGCAAAGATT
TGATCAAACAAGAAGCAAAACAAGCAAATGGAAATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References