Detailed information of TA system TA119728

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ(toxin)
• Location: 886074..886698
• Replicon: chromosome
• Accession: NZ_CP036393
• Organism: Helicobacter pylori strain 48A2

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: EYC15_RS04150
• Protein ID: WP_000916179.1
• Coordinates: 886074..886340 (-)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A1Q2RV02
• Locus tag: EYC15_RS04155
• Protein ID: WP_001133866.1
• Coordinates: 886321..886698 (-)
• Length: 126 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EYC15_RS04130	882722..883489	-	768	WP_000242367.1	ABC transporter ATP-binding protein	-
EYC15_RS04135	883489..884469	-	981	WP_000921437.1	iron ABC transporter permease	-
EYC15_RS04140	884462..885304	-	843	WP_000502529.1	SDR family oxidoreductase	-
EYC15_RS04145	885445..885969	+	525	WP_001120211.1	acyl-CoA thioesterase	-
EYC15_RS04150	886074..886340	-	267	WP_000916179.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	Toxin
EYC15_RS04155	886321..886698	-	378	WP_001133866.1	hypothetical protein	Antitoxin
EYC15_RS04160	887045..889132	-	2088	WP_188348602.1	Hop family adhesin BabB	-
EYC15_RS04165	889668..889925	-	258	WP_000440197.1	30S ribosomal protein S18	-
EYC15_RS04170	889949..890494	-	546	WP_000482461.1	single-stranded DNA-binding protein	-
EYC15_RS04175	890504..890944	-	441	WP_001216703.1	30S ribosomal protein S6	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (3-88)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10329.21 Da
• Isoelectric Point: 9.6292

>T119728 WP_000916179.1 NZ_CP036393:c886340-886074 [Helicobacter pylori]
VLKLNLKKSFQKDFDKLLLNGFDDSVLNKVILSLRKKEPLDPQFQDHALKGKWKPFRECHIKPDILLVYLVKDDELILVR
LGSHSELF

Nucleotide

• Length: 267 bp

>T119728 NZ_CP036393:c886340-886074 [Helicobacter pylori]
GTGTTGAAACTCAACCTTAAAAAATCTTTTCAAAAAGATTTTGATAAATTACTTTTGAATGGGTTTGATGATAGCGTTTT
GAATAAGGTCATTCTGTCTTTGAGAAAGAAAGAACCACTAGACCCCCAATTCCAAGATCATGCTTTAAAGGGGAAGTGGA
AACCTTTTAGGGAATGCCACATTAAACCTGATATTTTGCTTGTGTATTTAGTGAAAGATGATGAGCTTATTTTAGTAAGG
CTAGGCAGTCATAGCGAGCTGTTTTAA

Antitoxin

Protein

• Length: 126 a.a.
• Molecular weight: 14719.74 Da
• Isoelectric Point: 9.0037

>AT119728 WP_001133866.1 NZ_CP036393:c886698-886321 [Helicobacter pylori]
MPNSPTKKDYTQYSEKQLFNLINQLEQKIKKMQNDRASFKEKMAKELEKRDQNFKDKIDALNKLLQKISQAFDDKRDCCL
GRKIPNLETQQAMRDALNKETDLIVEDFSSYSDERKRALGVETQP

Nucleotide

• Length: 378 bp

>AT119728 NZ_CP036393:c886698-886321 [Helicobacter pylori]
ATGCCTAATTCTCCCACCAAAAAAGACTACACACAATACAGCGAAAAACAGCTTTTTAACTTAATCAACCAATTAGAGCA
AAAAATCAAAAAGATGCAAAATGATAGAGCTTCTTTTAAAGAAAAAATGGCTAAAGAATTGGAAAAAAGGGATCAAAACT
TTAAGGATAAAATAGACGCATTAAATAAACTCTTGCAAAAAATCAGCCAAGCTTTTGATGATAAAAGAGATTGTTGTTTG
GGGCGCAAGATCCCAAACCTTGAAACGCAACAAGCCATGAGAGATGCGCTTAACAAAGAAACCGATTTGATTGTTGAGGA
TTTTTCTAGTTATAGCGATGAAAGAAAAAGGGCGTTAGGTGTTGAAACTCAACCTTAA

Structures

Antitoxin

• AlphaFold DB: A0A1Q2RV02