Detailed information of TA system TA119726

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ(toxin)
• Location: 886077..886701
• Replicon: chromosome
• Accession: NZ_CP036392
• Organism: Helicobacter pylori strain 48C8

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: EYC16_RS04155
• Protein ID: WP_000916179.1
• Coordinates: 886077..886343 (-)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A1Q2RV02
• Locus tag: EYC16_RS04160
• Protein ID: WP_001133866.1
• Coordinates: 886324..886701 (-)
• Length: 126 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EYC16_RS04135	882725..883492	-	768	WP_000242367.1	ABC transporter ATP-binding protein	-
EYC16_RS04140	883492..884472	-	981	WP_000921437.1	iron ABC transporter permease	-
EYC16_RS04145	884465..885307	-	843	WP_000502529.1	SDR family oxidoreductase	-
EYC16_RS04150	885448..885972	+	525	WP_001120211.1	acyl-CoA thioesterase	-
EYC16_RS04155	886077..886343	-	267	WP_000916179.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	Toxin
EYC16_RS04160	886324..886701	-	378	WP_001133866.1	hypothetical protein	Antitoxin
EYC16_RS04165	887048..889135	-	2088	WP_188348602.1	Hop family adhesin BabB	-
EYC16_RS04170	889671..889928	-	258	WP_000440197.1	30S ribosomal protein S18	-
EYC16_RS04175	889952..890497	-	546	WP_000482461.1	single-stranded DNA-binding protein	-
EYC16_RS04180	890507..890947	-	441	WP_001216703.1	30S ribosomal protein S6	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (3-88)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10329.21 Da
• Isoelectric Point: 9.6292

>T119726 WP_000916179.1 NZ_CP036392:c886343-886077 [Helicobacter pylori]
VLKLNLKKSFQKDFDKLLLNGFDDSVLNKVILSLRKKEPLDPQFQDHALKGKWKPFRECHIKPDILLVYLVKDDELILVR
LGSHSELF

Nucleotide

• Length: 267 bp

>T119726 NZ_CP036392:c886343-886077 [Helicobacter pylori]
GTGTTGAAACTCAACCTTAAAAAATCTTTTCAAAAAGATTTTGATAAATTACTTTTGAATGGGTTTGATGATAGCGTTTT
GAATAAGGTCATTCTGTCTTTGAGAAAGAAAGAACCACTAGACCCCCAATTCCAAGATCATGCTTTAAAGGGGAAGTGGA
AACCTTTTAGGGAATGCCACATTAAACCTGATATTTTGCTTGTGTATTTAGTGAAAGATGATGAGCTTATTTTAGTAAGG
CTAGGCAGTCATAGCGAGCTGTTTTAA

Antitoxin

Protein

• Length: 126 a.a.
• Molecular weight: 14719.74 Da
• Isoelectric Point: 9.0037

>AT119726 WP_001133866.1 NZ_CP036392:c886701-886324 [Helicobacter pylori]
MPNSPTKKDYTQYSEKQLFNLINQLEQKIKKMQNDRASFKEKMAKELEKRDQNFKDKIDALNKLLQKISQAFDDKRDCCL
GRKIPNLETQQAMRDALNKETDLIVEDFSSYSDERKRALGVETQP

Nucleotide

• Length: 378 bp

>AT119726 NZ_CP036392:c886701-886324 [Helicobacter pylori]
ATGCCTAATTCTCCCACCAAAAAAGACTACACACAATACAGCGAAAAACAGCTTTTTAACTTAATCAACCAATTAGAGCA
AAAAATCAAAAAGATGCAAAATGATAGAGCTTCTTTTAAAGAAAAAATGGCTAAAGAATTGGAAAAAAGGGATCAAAACT
TTAAGGATAAAATAGACGCATTAAATAAACTCTTGCAAAAAATCAGCCAAGCTTTTGATGATAAAAGAGATTGTTGTTTG
GGGCGCAAGATCCCAAACCTTGAAACGCAACAAGCCATGAGAGATGCGCTTAACAAAGAAACCGATTTGATTGTTGAGGA
TTTTTCTAGTTATAGCGATGAAAGAAAAAGGGCGTTAGGTGTTGAAACTCAACCTTAA

Structures

Antitoxin

• AlphaFold DB: A0A1Q2RV02