Detailed information of TA system TA119708

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ(toxin)
• Location: 886030..886654
• Replicon: chromosome
• Accession: NZ_CP036383
• Organism: Helicobacter pylori strain 119A2

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: EYC25_RS04160
• Protein ID: WP_000916179.1
• Coordinates: 886030..886296 (-)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A1Q2RV02
• Locus tag: EYC25_RS04165
• Protein ID: WP_001133866.1
• Coordinates: 886277..886654 (-)
• Length: 126 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EYC25_RS04140	882678..883445	-	768	WP_000242367.1	ABC transporter ATP-binding protein	-
EYC25_RS04145	883445..884425	-	981	WP_000921437.1	iron ABC transporter permease	-
EYC25_RS04150	884418..885260	-	843	WP_000502529.1	SDR family oxidoreductase	-
EYC25_RS04155	885401..885925	+	525	WP_001120211.1	acyl-CoA thioesterase	-
EYC25_RS04160	886030..886296	-	267	WP_000916179.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	Toxin
EYC25_RS04165	886277..886654	-	378	WP_001133866.1	hypothetical protein	Antitoxin
EYC25_RS04170	887001..889127	-	2127	WP_188348615.1	Hop family adhesin BabB	-
EYC25_RS04175	889623..889880	-	258	WP_000440197.1	30S ribosomal protein S18	-
EYC25_RS04180	889904..890449	-	546	WP_000482461.1	single-stranded DNA-binding protein	-
EYC25_RS04185	890459..890899	-	441	WP_001216703.1	30S ribosomal protein S6	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (3-88)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10329.21 Da
• Isoelectric Point: 9.6292

>T119708 WP_000916179.1 NZ_CP036383:c886296-886030 [Helicobacter pylori]
VLKLNLKKSFQKDFDKLLLNGFDDSVLNKVILSLRKKEPLDPQFQDHALKGKWKPFRECHIKPDILLVYLVKDDELILVR
LGSHSELF

Nucleotide

• Length: 267 bp

>T119708 NZ_CP036383:c886296-886030 [Helicobacter pylori]
GTGTTGAAACTCAACCTTAAAAAATCTTTTCAAAAAGATTTTGATAAATTACTTTTGAATGGGTTTGATGATAGCGTTTT
GAATAAGGTCATTCTGTCTTTGAGAAAGAAAGAACCACTAGACCCCCAATTCCAAGATCATGCTTTAAAGGGGAAGTGGA
AACCTTTTAGGGAATGCCACATTAAACCTGATATTTTGCTTGTGTATTTAGTGAAAGATGATGAGCTTATTTTAGTAAGG
CTAGGCAGTCATAGCGAGCTGTTTTAA

Antitoxin

Protein

• Length: 126 a.a.
• Molecular weight: 14719.74 Da
• Isoelectric Point: 9.0037

>AT119708 WP_001133866.1 NZ_CP036383:c886654-886277 [Helicobacter pylori]
MPNSPTKKDYTQYSEKQLFNLINQLEQKIKKMQNDRASFKEKMAKELEKRDQNFKDKIDALNKLLQKISQAFDDKRDCCL
GRKIPNLETQQAMRDALNKETDLIVEDFSSYSDERKRALGVETQP

Nucleotide

• Length: 378 bp

>AT119708 NZ_CP036383:c886654-886277 [Helicobacter pylori]
ATGCCTAATTCTCCCACCAAAAAAGACTACACACAATACAGCGAAAAACAGCTTTTTAACTTAATCAACCAATTAGAGCA
AAAAATCAAAAAGATGCAAAATGATAGAGCTTCTTTTAAAGAAAAAATGGCTAAAGAATTGGAAAAAAGGGATCAAAACT
TTAAGGATAAAATAGACGCATTAAATAAACTCTTGCAAAAAATCAGCCAAGCTTTTGATGATAAAAGAGATTGTTGTTTG
GGGCGCAAGATCCCAAACCTTGAAACGCAACAAGCCATGAGAGATGCGCTTAACAAAGAAACCGATTTGATTGTTGAGGA
TTTTTCTAGTTATAGCGATGAAAGAAAAAGGGCGTTAGGTGTTGAAACTCAACCTTAA

Structures

Antitoxin

• AlphaFold DB: A0A1Q2RV02