Detailed information of TA system TA119690

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RelB(antitoxin)
• Location: 235411..236023
• Replicon: chromosome
• Accession: NZ_CP036376
• Organism: Streptococcus agalactiae strain Sag153

Toxin (Protein)

• Gene name: parE
• Uniprot ID: A0A8G2N8L3
• Locus tag: EXA24_RS01370
• Protein ID: WP_000384860.1
• Coordinates: 235411..235746 (-)
• Length: 112 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: Q8E7D2
• Locus tag: EXA24_RS01375
• Protein ID: WP_000259017.1
• Coordinates: 235736..236023 (-)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EXA24_RS01345	230609..231250	+	642	WP_000591144.1	hypothetical protein	-
EXA24_RS01350	231550..232425	+	876	WP_000421240.1	hypothetical protein	-
EXA24_RS01355	232461..232895	+	435	WP_001220479.1	hypothetical protein	-
EXA24_RS01360	233212..234468	+	1257	WP_000122836.1	plasmid recombination protein	-
EXA24_RS01365	234636..235106	+	471	WP_167839523.1	hypothetical protein	-
EXA24_RS01370	235411..235746	-	336	WP_000384860.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
EXA24_RS01375	235736..236023	-	288	WP_000259017.1	hypothetical protein	Antitoxin
EXA24_RS01380	236530..236820	+	291	WP_000078283.1	WXG100 family type VII secretion target	-
EXA24_RS01385	236922..237328	+	407	Protein_218	hypothetical protein	-
EXA24_RS01390	237328..237888	+	561	WP_001865562.1	hypothetical protein	-
EXA24_RS01395	237861..238541	+	681	WP_001865565.1	hypothetical protein	-
EXA24_RS01400	238526..238912	+	387	WP_000259069.1	hypothetical protein	-
EXA24_RS01405	238946..239227	+	282	WP_000052406.1	hypothetical protein	-
EXA24_RS01410	240059..240919	+	861	WP_000477654.1	Rgg/GadR/MutR family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	227442..236297	8855

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (8-106)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 112 a.a.
• Molecular weight: 13227.87 Da
• Isoelectric Point: 4.5348

>T119690 WP_000384860.1 NZ_CP036376:c235746-235411 [Streptococcus agalactiae]
MDYKKYQIIYAPDVLEKLKEIRDYISQNYSSTSGQRKMEQIINDIEKLEVFPEVGFDADEKYGSEISNYHSTRGYTLSKD
YIVLYHIEEEENSVVIDYLLPTRSDYMKLFK

Nucleotide

• Length: 336 bp

>T119690 NZ_CP036376:c235746-235411 [Streptococcus agalactiae]
TTGGACTATAAGAAATATCAGATTATCTATGCTCCTGATGTTTTAGAGAAGCTAAAAGAAATTCGTGATTATATTTCCCA
AAACTATTCCTCAACATCAGGTCAGCGTAAAATGGAGCAAATCATTAATGACATAGAAAAACTTGAAGTTTTCCCAGAAG
TTGGTTTTGATGCCGATGAAAAATATGGTTCAGAAATCAGCAATTATCACAGTACTAGAGGTTACACCTTAAGTAAAGAT
TATATTGTCCTATACCATATCGAAGAGGAAGAGAATAGCGTTGTCATTGATTACTTGCTTCCTACTCGAAGCGACTATAT
GAAATTGTTTAAATAG

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 10906.50 Da
• Isoelectric Point: 4.7271

>AT119690 WP_000259017.1 NZ_CP036376:c236023-235736 [Streptococcus agalactiae]
MVTVEKNRAVTFQANKELVSEAMTVLNKKNLTLSSALRLFLQNVVVTNEVDLLTEEELEKEKLFKQFQAEISKNIEDVRQ
GKFYTSEEVRAELGL

Nucleotide

• Length: 288 bp

>AT119690 NZ_CP036376:c236023-235736 [Streptococcus agalactiae]
ATGGTTACAGTAGAAAAAAATAGAGCTGTCACATTCCAAGCTAACAAAGAATTGGTAAGCGAAGCAATGACAGTATTAAA
CAAAAAAAATTTAACCTTATCATCTGCTTTAAGATTATTCCTACAAAATGTCGTTGTCACAAACGAGGTTGACTTATTGA
CGGAAGAGGAGTTAGAGAAAGAAAAACTTTTCAAGCAATTTCAAGCCGAAATCAGCAAAAATATTGAGGATGTTCGTCAA
GGGAAGTTTTATACCTCTGAAGAAGTGAGGGCTGAACTTGGACTATAA

Structures

Antitoxin

• AlphaFold DB: A0A076Z4V6