Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 2126701..2127320 Replicon chromosome
Accession NZ_CP036365
Organism Klebsiella pneumoniae strain WCHKP115068

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag DVJ72_RS10725 Protein ID WP_002892050.1
Coordinates 2126701..2126919 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag DVJ72_RS10730 Protein ID WP_002892066.1
Coordinates 2126946..2127320 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DVJ72_RS10695 2122748..2123011 + 264 WP_002892011.1 type B 50S ribosomal protein L31 -
DVJ72_RS10700 2123011..2123151 + 141 WP_002892018.1 type B 50S ribosomal protein L36 -
DVJ72_RS10705 2123148..2123846 - 699 WP_002892021.1 GNAT family N-acetyltransferase -
DVJ72_RS10710 2123947..2125398 + 1452 WP_002892023.1 PLP-dependent aminotransferase family protein -
DVJ72_RS10715 2125373..2125843 - 471 WP_002892026.1 YlaC family protein -
DVJ72_RS29260 2125864..2126004 + 141 WP_004147370.1 hypothetical protein -
DVJ72_RS10720 2125976..2126542 - 567 WP_002892030.1 maltose O-acetyltransferase -
DVJ72_RS10725 2126701..2126919 - 219 WP_002892050.1 hemolysin expression modulator Hha Toxin
DVJ72_RS10730 2126946..2127320 - 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
DVJ72_RS10735 2127806..2130952 - 3147 WP_020326861.1 multidrug efflux RND transporter permease subunit -
DVJ72_RS10740 2130975..2132168 - 1194 WP_002892072.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T119647 WP_002892050.1 NZ_CP036365:c2126919-2126701 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T119647 NZ_CP036365:c2126919-2126701 [Klebsiella pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACTTCTGTCTGGAAATTTATCCGCTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT119647 WP_002892066.1 NZ_CP036365:c2127320-2126946 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT119647 NZ_CP036365:c2127320-2126946 [Klebsiella pneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References