Detailed information of TA system TA119612

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/CC2985(antitoxin)
• Location: 449816..450360
• Replicon: chromosome
• Accession: NZ_CP036358
• Organism: Agrobacterium sp. 33MFTa1.1

Toxin (Protein)

• Gene name: parE
• Uniprot ID: U4PRC3
• Locus tag: EYD00_RS02220
• Protein ID: WP_004440407.1
• Coordinates: 450070..450360 (+)
• Length: 97 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: -
• Locus tag: EYD00_RS02215
• Protein ID: WP_004440406.1
• Coordinates: 449816..450067 (+)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EYD00_RS02185	444914..445603	-	690	WP_004440401.1	HAD family hydrolase	-
EYD00_RS02190	445818..446498	+	681	WP_004440402.1	GntR family transcriptional regulator	-
EYD00_RS02195	446539..447000	+	462	WP_034496277.1	DUF1284 domain-containing protein	-
EYD00_RS02200	446960..448060	-	1101	WP_034495932.1	hypothetical protein	-
EYD00_RS02210	448297..449442	+	1146	WP_004440405.1	site-specific DNA-methyltransferase	-
EYD00_RS02215	449816..450067	+	252	WP_004440406.1	type II toxin-antitoxin system ParD family antitoxin	Antitoxin
EYD00_RS02220	450070..450360	+	291	WP_004440407.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
EYD00_RS02225	450392..451003	-	612	WP_004440408.1	HAD family phosphatase	-
EYD00_RS02230	451086..452195	-	1110	WP_051674145.1	A/G-specific adenine glycosylase	-
EYD00_RS25820	452108..452344	+	237	WP_162484560.1	hypothetical protein	-
EYD00_RS02235	452322..452786	+	465	WP_034495929.1	hypothetical protein	-
EYD00_RS02240	452814..453335	+	522	WP_004440412.1	DUF721 domain-containing protein	-
EYD00_RS02245	453464..454144	+	681	WP_004440414.1	DsbA family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-92)

Antitoxin

• Antitoxin ParD (2-79)

Sequences

Toxin

Protein

• Length: 97 a.a.
• Molecular weight: 11253.77 Da
• Isoelectric Point: 6.6456

>T119612 WP_004440407.1 NZ_CP036358:450070-450360 [Agrobacterium sp. 33MFTa1.1]
MGFRLSLPAEEDVIRIAQEGIDLFGPQQARKYHRELFAIFDLISRNPRIARERNELSPSVRIHPFRAHLVVYRVEADDDV
LIVRVRHGHEDWGNEP

Nucleotide

• Length: 291 bp

>T119612 NZ_CP036358:450070-450360 [Agrobacterium sp. 33MFTa1.1]
ATGGGATTTCGCCTTTCTCTGCCTGCGGAAGAAGACGTCATCCGCATAGCGCAAGAAGGCATCGACCTATTTGGACCTCA
GCAAGCGCGAAAGTACCATCGCGAACTTTTCGCAATATTCGACTTGATATCACGGAATCCGAGGATCGCACGCGAGCGTA
ACGAGTTGTCGCCGTCGGTGCGCATTCATCCGTTCAGAGCACATCTGGTGGTCTATCGCGTTGAGGCGGACGACGACGTC
CTCATCGTCCGCGTCCGCCATGGGCACGAGGACTGGGGCAATGAGCCTTAA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9281.45 Da
• Isoelectric Point: 6.4680

>AT119612 WP_004440406.1 NZ_CP036358:449816-450067 [Agrobacterium sp. 33MFTa1.1]
MVTMNISLPGQMKEWVEAQSKTGRYSNASDYVRDLIRKDQERSEKIAAMQGLVDEGLQAPSGHRSEDALFAEAEARSMKH
KIG

Nucleotide

• Length: 252 bp

>AT119612 NZ_CP036358:449816-450067 [Agrobacterium sp. 33MFTa1.1]
ATGGTAACCATGAATATTTCGCTGCCCGGCCAGATGAAGGAGTGGGTCGAAGCGCAGTCTAAAACGGGCCGTTACTCCAA
TGCCAGCGACTATGTACGAGATCTCATCCGAAAGGATCAGGAGCGGAGCGAAAAGATCGCTGCCATGCAGGGCCTGGTGG
ACGAAGGATTGCAGGCTCCCTCCGGTCATCGTTCTGAAGATGCCTTGTTTGCTGAGGCCGAAGCCCGCTCCATGAAACAT
AAAATTGGCTGA

Structures

Toxin

• AlphaFold DB: U4PRC3