Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/MazF(toxin)
Location 2437384..2438026 Replicon chromosome
Accession NZ_CP036356
Organism Bacillus sp. SYJ

Toxin (Protein)


Gene name pemK Uniprot ID J8CWW5
Locus tag EYB51_RS14115 Protein ID WP_000635963.1
Coordinates 2437676..2438026 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID R8I8H2
Locus tag EYB51_RS14110 Protein ID WP_000004570.1
Coordinates 2437384..2437671 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EYB51_RS14085 2432549..2433511 + 963 WP_087967864.1 UV DNA damage repair endonuclease UvsE -
EYB51_RS14090 2433679..2434227 - 549 WP_087967862.1 rhomboid family intramembrane serine protease -
EYB51_RS14095 2434320..2434679 + 360 WP_000635047.1 holo-ACP synthase -
EYB51_RS14100 2434836..2435786 + 951 WP_131102695.1 outer membrane lipoprotein carrier protein LolA -
EYB51_RS14105 2435906..2437075 + 1170 WP_048553601.1 alanine racemase -
EYB51_RS14110 2437384..2437671 + 288 WP_000004570.1 antitoxin EndoAI Antitoxin
EYB51_RS14115 2437676..2438026 + 351 WP_000635963.1 type II toxin-antitoxin system endoribonuclease NdoA Toxin
EYB51_RS14120 2438094..2440262 + 2169 WP_131101278.1 RNA-binding transcriptional accessory protein -
EYB51_RS14125 2440320..2440436 - 117 WP_001143642.1 cortex morphogenetic protein CmpA -
EYB51_RS14130 2440632..2441090 + 459 WP_087967857.1 SprT family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-113)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12974.12 Da        Isoelectric Point: 5.7168

>T119610 WP_000635963.1 NZ_CP036356:2437676-2438026 [Bacillus sp. SYJ]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEIDAKKYGFERDSVILLEQI
RTIDKQRLTDKITHLDEVMMIRVDEALQISLGLIDF

Download         Length: 351 bp

>T119610 NZ_CP036356:2437676-2438026 [Bacillus sp. SYJ]
TTGATTGTAAAACGCGGCGACGTGTATTTTGCAGACCTTTCCCCAGTTGTTGGTTCTGAGCAAGGAGGCGTTCGTCCGGT
TCTTGTCATTCAAAATGACATCGGAAATCGTTTTAGTCCAACGGTGATTGTAGCGGCTATTACTGCACAGATTCAAAAAG
CGAAATTACCCACTCATGTGGAAATTGATGCGAAAAAGTACGGTTTTGAGAGAGATTCTGTTATTTTACTTGAGCAGATT
CGAACAATCGATAAGCAGCGCTTAACGGACAAAATCACTCACTTAGATGAAGTGATGATGATTCGTGTAGATGAAGCGCT
ACAAATTAGTTTAGGACTAATAGATTTTTAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10780.36 Da        Isoelectric Point: 8.9605

>AT119610 WP_000004570.1 NZ_CP036356:2437384-2437671 [Bacillus sp. SYJ]
VSESSVTTEIVVRLPKQMVTELDGIGKQENKNRHELICQATQLLLRQHKTKKRYQHESMRRGYIEMGKINLGIASEAFLA
EYEAAHTVERLVSGG

Download         Length: 288 bp

>AT119610 NZ_CP036356:2437384-2437671 [Bacillus sp. SYJ]
GTGTCCGAATCAAGTGTAACTACTGAAATCGTGGTTCGGTTACCAAAGCAAATGGTAACGGAATTGGACGGAATTGGAAA
ACAAGAGAATAAGAATCGCCATGAACTAATTTGCCAGGCAACACAACTGTTATTGCGTCAACATAAGACGAAGAAACGCT
ACCAACATGAATCAATGCGACGTGGGTACATTGAAATGGGAAAAATTAATCTTGGTATTGCATCTGAAGCTTTCTTAGCA
GAGTATGAAGCAGCTCATACAGTAGAACGCTTAGTTAGCGGGGGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4HKE
PDB 7BXY

Antitoxin

Source ID Structure
AlphaFold DB A0A366FY90

References