Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 2436999..2438665 Replicon chromosome
Accession NZ_CP036344
Organism Achromobacter denitrificans strain TB

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag EUC41_RS11520 Protein ID WP_088148630.1
Coordinates 2436999..2437838 (+) Length 280 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID -
Locus tag EUC41_RS11525 Protein ID WP_088148631.1
Coordinates 2437850..2438665 (+) Length 272 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EUC41_RS11495 (EUC41_11410) 2432518..2433276 - 759 WP_075873249.1 ABC transporter permease -
EUC41_RS11500 (EUC41_11415) 2433278..2434066 - 789 WP_075873250.1 ABC transporter ATP-binding protein -
EUC41_RS11505 (EUC41_11420) 2434059..2435006 - 948 WP_075873255.1 ABC transporter substrate-binding protein -
EUC41_RS11510 (EUC41_11425) 2435106..2435699 - 594 WP_228468166.1 cupin domain-containing protein -
EUC41_RS11515 (EUC41_11430) 2435791..2436846 - 1056 WP_088148629.1 porin -
EUC41_RS11520 (EUC41_11435) 2436999..2437838 + 840 WP_088148630.1 alpha/beta hydrolase Toxin
EUC41_RS11525 (EUC41_11440) 2437850..2438665 + 816 WP_088148631.1 IclR family transcriptional regulator Antitoxin
EUC41_RS11530 (EUC41_11445) 2438727..2439518 + 792 WP_176438952.1 SDR family oxidoreductase -
EUC41_RS11535 (EUC41_11450) 2439511..2441181 + 1671 WP_088148633.1 thiamine pyrophosphate-binding protein -
EUC41_RS11540 (EUC41_11455) 2441189..2441986 + 798 WP_088148634.1 aspartate dehydrogenase -
EUC41_RS11545 (EUC41_11460) 2441994..2443485 + 1492 Protein_2290 aldehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(39-270)

Antitoxin

Transcription regulator IclR, C-terminal

(138-260)


Sequences

Toxin        


Download         Length: 280 a.a.        Molecular weight: 29066.18 Da        Isoelectric Point: 7.8874

>T119609 WP_088148630.1 NZ_CP036344:2436999-2437838 [Achromobacter denitrificans]
MPATEQAMRDQALHRFTACLAPTAQGPSAYRRLGTGPAVVLLHGIGSGSGCWLDAATALAGECTVLAWDAPGYGASAPLA
GDRPSAADYAERLHQVLRHAGIDECVLVGHSLGALVAAAYCARRERAGISRLVLLSPARGYGSAEAGEREATRGKRLGAL
ERLGIDGMAAARASALLSPAARAGQVQWAAWNMRQITPEGYRQAVGLLCDGDLLAFPAPPMSVDVRVGIHDTITPAPKCQ
AIAAAWRASFELIPGAGHACHIERPQEVAEIVRQARAGS

Download         Length: 840 bp

>T119609 NZ_CP036344:2436999-2437838 [Achromobacter denitrificans]
ATGCCCGCTACCGAGCAAGCCATGCGCGATCAGGCGCTGCATCGCTTTACCGCCTGCCTGGCTCCCACCGCGCAGGGCCC
GTCGGCCTACCGCCGATTGGGCACGGGACCAGCCGTCGTTTTGCTGCATGGCATCGGCTCGGGATCGGGCTGCTGGCTCG
ACGCCGCGACGGCGCTTGCCGGGGAATGCACGGTCTTGGCCTGGGACGCGCCGGGCTATGGCGCGTCGGCGCCGCTGGCC
GGGGATCGGCCTTCGGCGGCCGACTACGCGGAACGGCTGCACCAGGTCCTGCGCCACGCCGGCATCGACGAATGCGTGCT
GGTCGGCCATTCGCTGGGCGCGCTCGTAGCGGCGGCCTATTGCGCGCGGCGGGAACGGGCGGGGATCTCGCGCCTGGTCT
TGCTGAGCCCCGCGCGCGGCTATGGGTCGGCCGAGGCGGGCGAACGCGAGGCCACGCGCGGCAAGCGCCTGGGCGCGCTC
GAACGCCTGGGCATCGACGGCATGGCGGCGGCCCGCGCCAGCGCCCTGCTGTCGCCGGCGGCGCGGGCCGGGCAGGTGCA
ATGGGCCGCCTGGAACATGCGGCAGATCACCCCGGAGGGCTATCGCCAGGCCGTGGGGCTGCTGTGCGACGGCGACCTGC
TGGCCTTCCCCGCCCCGCCCATGTCCGTGGATGTGCGGGTGGGGATTCATGACACCATTACGCCTGCGCCAAAGTGCCAG
GCAATCGCCGCGGCATGGCGGGCATCGTTTGAGCTAATCCCCGGGGCGGGCCATGCCTGCCATATCGAGCGGCCGCAGGA
GGTCGCCGAAATCGTGCGCCAGGCGCGCGCCGGTTCCTGA

Antitoxin


Download         Length: 272 a.a.        Molecular weight: 29529.53 Da        Isoelectric Point: 6.0246

>AT119609 WP_088148631.1 NZ_CP036344:2437850-2438665 [Achromobacter denitrificans]
MSDTDVNDDGRDRYTVPALERGLRLLCQFNRNDRALGAPELARRLDLPRSTVFRMLNTLEHMGFVRKTDGGSTYQLDMGV
LRLGFEYLASLELTELGRPLLERVRDATGYPSNLVVLDQHWAVVVAKSSAPTPFVSTVYVGTRLPAHATLLGRALLCDLS
LDALRNLYGDAPLQSYSPRTPGTVEALHEVLQQDRARGYVSDHGFYEAAVASIAAPVRDRNGATMAALGVTIPTMTTTQP
AMDEAGVIATVRSAADELSRLLDYAPPGATR

Download         Length: 816 bp

>AT119609 NZ_CP036344:2437850-2438665 [Achromobacter denitrificans]
ATGAGTGACACCGATGTGAATGACGACGGTCGCGACCGCTACACCGTCCCCGCGCTGGAGCGCGGCCTGCGCCTGCTGTG
CCAGTTCAACCGCAACGACCGCGCGCTGGGCGCGCCCGAACTGGCGCGCCGGCTCGACCTCCCCCGGTCGACCGTGTTCC
GCATGCTCAATACGCTGGAGCACATGGGCTTCGTGCGCAAGACCGACGGCGGCTCCACCTACCAGCTGGACATGGGCGTG
CTCCGCCTGGGCTTCGAGTACCTGGCCTCGCTGGAACTGACGGAGCTCGGCCGCCCCTTGCTGGAACGCGTGCGCGACGC
CACCGGCTACCCCTCCAACCTGGTGGTGCTGGACCAGCACTGGGCCGTGGTGGTGGCCAAATCGTCCGCGCCCACCCCTT
TCGTCAGCACGGTCTACGTCGGCACCCGCCTGCCGGCGCATGCCACCTTGCTGGGCCGCGCCCTGCTCTGCGACCTGAGC
CTGGACGCGCTGCGGAATCTCTATGGCGACGCGCCGCTGCAAAGCTATTCGCCACGCACGCCGGGCACGGTGGAAGCGCT
GCACGAGGTGCTGCAGCAGGACCGCGCGCGCGGCTACGTGAGCGATCACGGCTTCTATGAGGCTGCCGTCGCCAGCATCG
CCGCGCCCGTGCGCGATCGCAACGGCGCCACCATGGCCGCGCTGGGCGTGACGATACCGACGATGACCACCACGCAGCCG
GCCATGGACGAAGCGGGCGTGATCGCCACCGTGCGCAGCGCGGCCGACGAGTTGTCGCGCTTACTGGATTACGCGCCACC
CGGCGCGACGCGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References