Detailed information of TA system TA119608

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-Phd
• Location: 637641..638302
• Replicon: chromosome
• Accession: NZ_CP036344
• Organism: Achromobacter denitrificans strain TB

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: A0A3R9GKR9
• Locus tag: EUC41_RS02930
• Protein ID: WP_062682299.1
• Coordinates: 637641..638054 (-)
• Length: 138 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: EUC41_RS02935
• Protein ID: WP_062682298.1
• Coordinates: 638051..638302 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EUC41_RS02905 (EUC41_02915)	632977..633576	-	600	WP_062682301.1	C40 family peptidase	-
EUC41_RS02910 (EUC41_02920)	633909..635405	+	1497	WP_062682325.1	AMP nucleosidase	-
EUC41_RS02915 (EUC41_02925)	635636..637120	+	1485	WP_062682324.1	amino acid permease	-
EUC41_RS02920	637164..637331	-	168	WP_174716328.1	hypothetical protein	-
EUC41_RS02925 (EUC41_02930)	637423..637632	-	210	WP_277757254.1	hypothetical protein	-
EUC41_RS02930 (EUC41_02935)	637641..638054	-	414	WP_062682299.1	type II toxin-antitoxin system VapC family toxin	Toxin
EUC41_RS02935 (EUC41_02940)	638051..638302	-	252	WP_062682298.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
EUC41_RS02940 (EUC41_02945)	638371..638751	+	381	WP_277757255.1	hypothetical protein	-
EUC41_RS02945 (EUC41_02950)	638809..639738	-	930	WP_088148891.1	YicC/YloC family endoribonuclease	-
EUC41_RS02950 (EUC41_02955)	639922..640659	+	738	WP_062682297.1	ribonuclease PH	-
EUC41_RS02955 (EUC41_02960)	640914..642365	+	1452	WP_232481991.1	aldehyde dehydrogenase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (3-124)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-64)

Sequences

Toxin

Protein

• Length: 138 a.a.
• Molecular weight: 15466.80 Da
• Isoelectric Point: 5.2418

>T119608 WP_062682299.1 NZ_CP036344:c638054-637641 [Achromobacter denitrificans]
MSYLVDTNVLSELRRKQPDGNVVRWLEQRPATTLFLSALTMGELRKGIELMPEGERKRSYLDWLEVELPRFFSGRVLAID
EPVADCWGRLVAQAGRALPAIDSLLAATALAHGLTLVTRNERDFQHPGLDVINPWEV

Nucleotide

• Length: 414 bp

>T119608 NZ_CP036344:c638054-637641 [Achromobacter denitrificans]
TTGAGCTATCTCGTGGATACCAATGTCCTGTCGGAGTTGCGTCGAAAGCAACCGGACGGCAACGTGGTCAGGTGGTTGGA
GCAGCGCCCCGCCACAACACTATTCCTATCCGCACTGACGATGGGCGAGCTTCGCAAAGGCATCGAACTGATGCCGGAGG
GCGAACGAAAACGCAGTTATCTGGACTGGCTGGAAGTTGAGCTTCCCCGGTTCTTCAGCGGCCGCGTGCTGGCCATCGAC
GAACCCGTCGCGGATTGCTGGGGACGTTTGGTGGCTCAAGCGGGGCGCGCGTTGCCGGCCATCGACAGTTTGCTGGCGGC
CACGGCGCTCGCGCACGGACTGACACTGGTCACGCGCAACGAACGGGATTTCCAACATCCGGGCCTGGATGTCATCAACC
CCTGGGAAGTTTGA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9054.16 Da
• Isoelectric Point: 5.0760

>AT119608 WP_062682298.1 NZ_CP036344:c638302-638051 [Achromobacter denitrificans]
MHVWQMQEAKSRLSEVVKAAGTQGPQEITVHGRSVAVVLSRADFDKLSGTGESLVAFMRRSPLAGDEDLAFPRDDSPTRE
EGL

Nucleotide

• Length: 252 bp

>AT119608 NZ_CP036344:c638302-638051 [Achromobacter denitrificans]
ATGCACGTCTGGCAAATGCAAGAAGCCAAATCCCGCTTGTCCGAAGTCGTCAAAGCGGCCGGAACCCAAGGTCCACAGGA
AATCACCGTGCACGGCCGTTCTGTGGCTGTCGTGCTCTCTCGGGCGGACTTCGACAAACTTTCAGGCACGGGAGAATCTC
TGGTCGCCTTCATGCGCCGCTCTCCACTGGCCGGAGATGAAGACCTCGCCTTTCCCCGTGACGACAGCCCGACGCGCGAG
GAAGGACTTTGA

Structures

Toxin

• AlphaFold DB: A0A3R9GKR9