119604

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 46003..46525 Replicon plasmid pIncHIB
Accession NZ_CP036336
Organism Klebsiella pneumoniae strain BP327

Toxin (Protein)


Gene name stbE Uniprot ID A0A0C7KG00
Locus tag EYB55_RS27090 Protein ID WP_038991638.1
Coordinates 46241..46525 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID A0A2J4R0U8
Locus tag EYB55_RS27085 Protein ID WP_004181777.1
Coordinates 46003..46251 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EYB55_RS27065 41212..42033 - 822 WP_004181772.1 hypothetical protein -
EYB55_RS27070 42095..42448 - 354 WP_004181774.1 hypothetical protein -
EYB55_RS27075 42593..43579 - 987 WP_040120328.1 hypothetical protein -
EYB55_RS27080 43913..45712 - 1800 WP_038991636.1 ATP-dependent helicase -
EYB55_RS27085 46003..46251 + 249 WP_004181777.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
EYB55_RS27090 46241..46525 + 285 WP_038991638.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
EYB55_RS27095 46542..46643 - 102 Protein_49 IS200/IS605 family transposase -
EYB55_RS27100 46679..47903 + 1225 Protein_50 transposase -
EYB55_RS27105 48175..48399 - 225 Protein_51 transposase -
EYB55_RS27110 48478..48906 - 429 WP_077256229.1 IS200/IS605 family transposase -
EYB55_RS27115 48942..50128 + 1187 Protein_53 transposase -
EYB55_RS27120 50227..51322 - 1096 Protein_54 conjugal transfer protein TraG N-terminal domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid mph(E) / msr(E) / armA / sul1 / qacE / aadA2 / dfrA12 / blaCTX-M-15 / blaTEM-1B / aph(6)-Id / aph(3'')-Ib / sul2 - 1..242563 242563


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10993.73 Da        Isoelectric Point: 10.6516

>T119604 WP_038991638.1 NZ_CP036336:46241-46525 [Klebsiella pneumoniae]
MTYKLAFNESALKEWKKLGHTIREQFKKKLAERLLNPRVPASQLHGRKDQYKIKLRGAGYRLVYSVNDDVVTVTVIGVGK
RENDDIYHLTKHRN

Download         Length: 285 bp

>T119604 NZ_CP036336:46241-46525 [Klebsiella pneumoniae]
ATGACTTATAAGCTGGCCTTTAATGAATCAGCTCTGAAAGAATGGAAAAAATTGGGCCATACCATTCGGGAACAATTCAA
AAAGAAGCTCGCTGAGCGCCTGTTGAACCCACGGGTGCCCGCATCGCAACTACATGGACGCAAAGACCAATACAAAATAA
AGCTCCGTGGCGCAGGCTACCGACTGGTTTACAGTGTCAACGATGATGTTGTGACGGTCACCGTAATTGGCGTCGGTAAA
CGTGAGAATGATGATATTTACCATTTAACCAAACACAGAAATTAA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 8925.17 Da        Isoelectric Point: 3.8209

>AT119604 WP_004181777.1 NZ_CP036336:46003-46251 [Klebsiella pneumoniae]
MAFQVLTTTAASITELKRDPMGTFNAGEGAPVAILNRNEPAFYCVPPALYAQLMELLEDQELGRIADERIGEAVIEVSLD
DL

Download         Length: 249 bp

>AT119604 NZ_CP036336:46003-46251 [Klebsiella pneumoniae]
ATGGCATTTCAGGTACTAACCACTACTGCAGCAAGCATCACAGAGCTTAAACGTGATCCTATGGGCACTTTCAATGCAGG
AGAAGGTGCCCCGGTAGCCATACTGAATCGCAACGAACCCGCTTTTTACTGTGTACCGCCTGCTCTGTATGCTCAACTGA
TGGAGCTTCTTGAAGATCAGGAGTTGGGTCGTATTGCTGATGAGCGAATTGGTGAGGCGGTAATCGAGGTCAGTCTAGAT
GACTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0C7KG00

Antitoxin

Source ID Structure
AlphaFold DB A0A2J4R0U8

References