Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4877763..4878420 Replicon chromosome
Accession NZ_CP036335
Organism Klebsiella pneumoniae strain BP327

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag EYB55_RS24255 Protein ID WP_002916310.1
Coordinates 4878010..4878420 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag EYB55_RS24250 Protein ID WP_002916312.1
Coordinates 4877763..4878029 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EYB55_RS24225 4872919..4874352 - 1434 WP_004185559.1 6-phospho-beta-glucosidase BglA -
EYB55_RS24230 4874471..4875199 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
EYB55_RS24235 4875249..4875560 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
EYB55_RS24240 4875724..4876383 + 660 WP_002916317.1 hemolysin III family protein -
EYB55_RS24245 4876534..4877517 - 984 WP_020324927.1 tRNA-modifying protein YgfZ -
EYB55_RS24250 4877763..4878029 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
EYB55_RS24255 4878010..4878420 + 411 WP_002916310.1 protein YgfX Toxin
EYB55_RS24260 4878427..4878948 - 522 WP_004144730.1 flavodoxin FldB -
EYB55_RS24265 4879049..4879945 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
EYB55_RS24270 4879968..4880681 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
EYB55_RS24275 4880687..4882420 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T119603 WP_002916310.1 NZ_CP036335:4878010-4878420 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T119603 NZ_CP036335:4878010-4878420 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGACGGATCCATGCCCGTCGCGGGGAAATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAGATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT119603 WP_002916312.1 NZ_CP036335:4877763-4878029 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT119603 NZ_CP036335:4877763-4878029 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References