Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3400308..3401143 Replicon chromosome
Accession NZ_CP036335
Organism Klebsiella pneumoniae strain BP327

Toxin (Protein)


Gene name yeeV Uniprot ID A0A5E2RWI0
Locus tag EYB55_RS16910 Protein ID WP_001559913.1
Coordinates 3400308..3400685 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A5E3EVB5
Locus tag EYB55_RS16915 Protein ID WP_032408847.1
Coordinates 3400775..3401143 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EYB55_RS16870 3395574..3395840 + 267 WP_004178415.1 hypothetical protein -
EYB55_RS16875 3395840..3396512 + 673 Protein_3246 DUF4400 domain-containing protein -
EYB55_RS16880 3396523..3397407 + 885 WP_104013999.1 RES domain-containing protein -
EYB55_RS16885 3397606..3397794 - 189 Protein_3248 transposase -
EYB55_RS16890 3397811..3398922 - 1112 Protein_3249 IS3 family transposase -
EYB55_RS30275 3399369..3399521 - 153 WP_164713811.1 hypothetical protein -
EYB55_RS16900 3399606..3399803 - 198 WP_032408848.1 DUF957 domain-containing protein -
EYB55_RS16905 3399823..3400311 - 489 WP_001559914.1 hypothetical protein -
EYB55_RS16910 3400308..3400685 - 378 WP_001559913.1 TA system toxin CbtA family protein Toxin
EYB55_RS16915 3400775..3401143 - 369 WP_032408847.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
EYB55_RS16920 3401320..3401541 - 222 WP_000692300.1 DUF987 domain-containing protein -
EYB55_RS16925 3401610..3402086 - 477 WP_032408846.1 RadC family protein -
EYB55_RS16930 3402101..3402586 - 486 WP_032408845.1 antirestriction protein -
EYB55_RS16935 3402678..3403496 - 819 WP_001559911.1 DUF945 domain-containing protein -
EYB55_RS16945 3403596..3403829 - 234 WP_001119729.1 DUF905 family protein -
EYB55_RS16950 3403908..3404363 - 456 WP_000581504.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 3388686..3420164 31478


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14148.10 Da        Isoelectric Point: 7.8276

>T119597 WP_001559913.1 NZ_CP036335:c3400685-3400308 [Klebsiella pneumoniae]
MKTLPDTHVREASRCPSPVTIWQTLLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQSGF
SACTHSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEAKR

Download         Length: 378 bp

>T119597 NZ_CP036335:c3400685-3400308 [Klebsiella pneumoniae]
ATGAAAACATTACCCGATACACACGTACGGGAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACTCTGCTCTC
CCGACTGCTGGACCAGCATTACGGCCTTACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTACGTACCGACCAGTCGGGATTC
AGCGCCTGTACCCACTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCCGGGCAACAGGCCTGATGACTCGCGA
CAATTACAGAACGGTAAATAACATTACCCTAGGGAAGCATCCGGAGGCGAAACGATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13682.62 Da        Isoelectric Point: 7.8398

>AT119597 WP_032408847.1 NZ_CP036335:c3401143-3400775 [Klebsiella pneumoniae]
VSDKLSGITHPDDNHDRPWWGLPCTVRPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVMLYAKGLTCKADTLGSGGYVYLAVYPTPETKK

Download         Length: 369 bp

>AT119597 NZ_CP036335:c3401143-3400775 [Klebsiella pneumoniae]
GTGTCAGACAAACTCTCCGGGATAACTCATCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTTCCCTGCACAGTGAG
GCCCTGTTTTGGTGCCCGTCTGGTGCAGGAGGGTAACCGCCTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGCT
TCAGCGACGCAGATGCATACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCATGCTGTATGCGAAAGGTCTGACCTGCAAAGCTGACACCCTCGGTAGCGG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5E2RWI0

Antitoxin

Source ID Structure
AlphaFold DB A0A5E3EVB5

References